Reviewed, UniProtKB/Swiss-Prot A5TYV9 (GABD1_MYCTA)

Names and origin

Protein names

Recommended name:
    Succinate-semialdehyde dehydrogenase [NADP+] 1
      Short name=SSADH 1
      Short name=SSDH 1
    EC=1.2.1.16

Gene names

Name:	gabD1
Ordered Locus Names:	MRA_0242

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.
Catalytic activity	Succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Succinate-semialdehyde dehydrogenase [NADP+] 1		PRO_0000310706
Regions
	Nucleotide binding	209 – 214	6	NAD or NADP By similarity
	Compositional bias	19 – 117	99	Ala-rich
Sites
	Active site	231	1	By similarity
	Active site	265	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5TYV9-1 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: B391266C5441A05F	FASTA	457	48,545
	10 20 30 40 50 60 MPIATINPAT GETVKTFTAA TDDEVDAAIA RAHRRFADYR QTSFAQRARW ANATADLLEA 70 80 90 100 110 120 EADQAAAMMT LEMGKTLAAA KAEALKCAKG FRYYAENAEA LLADEPADAA KVGASAAYGR 130 140 150 160 170 180 YQPLGVILAV MPWNFPLWQA VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPD 190 200 210 220 230 240 GCFQTLLVSS GAVEAILRDP RVAAATLTGS EPAGQSVGAI AGNEIKPTVL ELGGSDPFIV 250 260 270 280 290 300 MPSADLDAAV STAVTGRVQN NGQSCIAAKR FIVHADIYDD FVDKFVARMA ALRVGDPTDP 310 320 330 340 350 360 DTDVGPLATE QGRNEVAKQV EDAAAAGAVI RCGGKRLDRP GWFYPPTVIT DISKDMALYT 370 380 390 400 410 420 EEVFGPVASV FRAANIDEAV EIANATTFGL GSNAWTRDET EQRRFIDDIV AGQVFINGMT 430 440 450 VSYPELPFGG VKRSGYGREL SAHGIREFCN IKTVWIA

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000611 Genomic DNA. Translation: ABQ71959.1. Different initiation.
RefSeq	YP_001281521.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5TYV9.
Genome annotation databases
GeneID	5214190.
GenomeReviews	Gene locus MRA_0242 in contig CP000611_GR.
KEGG	mra:MRA_0242.
Organism-specific databases
CMR	Search...
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD1_MYCTA

Accession

Primary (citable) accession number: A5TYV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	October 13, 2009
This is version 18 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)