A5TYV9 (GABD1_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinate-semialdehyde dehydrogenase [NADP+] 1
Short name=SSADH 1
Short name=SSDH 1
EC=1.2.1.79

Gene names

Name:	gabD1
Ordered Locus Names:	MRA_0242

Organism

Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]

Taxonomic identifier

419947 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.
Catalytic activity	Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Sequence caution	The sequence ABQ71959.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Succinate-semialdehyde dehydrogenase [NADP+] 1		PRO_0000310706
Regions
	Nucleotide binding	133 – 134	2	NADP By similarity
	Nucleotide binding	157 – 160	4	NADP By similarity
	Nucleotide binding	209 – 210	2	NADP By similarity
	Compositional bias	19 – 117	99	Ala-rich
Sites
	Active site	231	1	Proton acceptor By similarity
	Active site	265	1	Nucleophile By similarity
	Binding site	232	1	NADP; via carbonyl oxygen By similarity
	Binding site	362	1	NADP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5TYV9 [UniParc]. Last modified November 13, 2007. Version 2. Checksum: B391266C5441A05F	FASTA	457	48,545
	10 20 30 40 50 60 MPIATINPAT GETVKTFTAA TDDEVDAAIA RAHRRFADYR QTSFAQRARW ANATADLLEA 70 80 90 100 110 120 EADQAAAMMT LEMGKTLAAA KAEALKCAKG FRYYAENAEA LLADEPADAA KVGASAAYGR 130 140 150 160 170 180 YQPLGVILAV MPWNFPLWQA VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPD 190 200 210 220 230 240 GCFQTLLVSS GAVEAILRDP RVAAATLTGS EPAGQSVGAI AGNEIKPTVL ELGGSDPFIV 250 260 270 280 290 300 MPSADLDAAV STAVTGRVQN NGQSCIAAKR FIVHADIYDD FVDKFVARMA ALRVGDPTDP 310 320 330 340 350 360 DTDVGPLATE QGRNEVAKQV EDAAAAGAVI RCGGKRLDRP GWFYPPTVIT DISKDMALYT 370 380 390 400 410 420 EEVFGPVASV FRAANIDEAV EIANATTFGL GSNAWTRDET EQRRFIDDIV AGQVFINGMT 430 440 450 VSYPELPFGG VKRSGYGREL SAHGIREFCN IKTVWIA

References

[1]

"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv." Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25177 / H37Ra.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000611 Genomic DNA. Translation: ABQ71959.1. Different initiation.
RefSeq	YP_001281521.1. NC_009525.1.
3D structure databases
ProteinModelPortal	A5TYV9.
ModBase	Search...
Protein-protein interaction databases
STRING	A5TYV9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000065235; EBMYCP00000063345; EBMYCG00000065230.
GeneID	5214190.
GenomeReviews	Gene locus MRA_0242 in contig CP000611_GR.
KEGG	mra:MRA_0242.
PATRIC	18140085. VBIMycTub106795_0264.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1012.
GeneTree	EBGT00050000015659.
HOGENOM	HBG752218.
ProtClustDB	PRK09406.
Enzyme and pathway databases
BioCyc	MTUB419947:MRA_0242-MONOMER.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00135.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD1_MYCTA

Accession

Primary (citable) accession number: A5TYV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program