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A5TY69 (DNAA_MYCTA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chromosomal replication initiator protein DnaA
Gene names
Name:dnaA
Ordered Locus Names:MRA_0001
OrganismMycobacterium tuberculosis (strain ATCC 25177 / H37Ra) [Complete proteome] [HAMAP]
Taxonomic identifier419947 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377

Subcellular location

Cytoplasm By similarity HAMAP MF_00377.

Sequence similarities

Belongs to the DnaA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Chromosomal replication initiator protein DnaA HAMAP MF_00377
PRO_1000048674

Regions

Nucleotide binding208 – 2158ATP Potential

Secondary structure

1 ............. 507
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A5TY69 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: C4F252150D453A00

FASTA50756,567
        10         20         30         40         50         60 
MTDDPGSGFT TVWNAVVSEL NGDPKVDDGP SSDANLSAPL TPQQRAWLNL VQPLTIVEGF 

        70         80         90        100        110        120 
ALLSVPSSFV QNEIERHLRA PITDALSRRL GHQIQLGVRI APPATDEADD TTVPPSENPA 

       130        140        150        160        170        180 
TTSPDTTTDN DEIDDSAAAR GDNQHSWPSY FTERPHNTDS ATAGVTSLNR RYTFDTFVIG 

       190        200        210        220        230        240 
ASNRFAHAAA LAIAEAPARA YNPLFIWGES GLGKTHLLHA AGNYAQRLFP GMRVKYVSTE 

       250        260        270        280        290        300 
EFTNDFINSL RDDRKVAFKR SYRDVDVLLV DDIQFIEGKE GIQEEFFHTF NTLHNANKQI 

       310        320        330        340        350        360 
VISSDRPPKQ LATLEDRLRT RFEWGLITDV QPPELETRIA ILRKKAQMER LAVPDDVLEL 

       370        380        390        400        410        420 
IASSIERNIR ELEGALIRVT AFASLNKTPI DKALAEIVLR DLIADANTMQ ISAATIMAAT 

       430        440        450        460        470        480 
AEYFDTTVEE LRGPGKTRAL AQSRQIAMYL CRELTDLSLP KIGQAFGRDH TTVMYAQRKI 

       490        500 
LSEMAERREV FDHVKELTTR IRQRSKR

« Hide

References

[1]"Complete genomic sequence of Mycobacterium tuberculosis strain H37Ra, a non-pathogenic variant closely related to the well-characterized pathogenic strain H37Rv."
Wang S.Y., Zheng H.J., Lv L.D., Wang B.F., Zhang X.L., Pu S.Y., Zhu G.F., Wang H.H., Zhao G.P., Zhang Y.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25177 / H37Ra.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000611 Genomic DNA. Translation: ABQ71719.1.
RefSeqYP_001281281.1. NC_009525.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3PVPX-ray2.30A/B411-507[»]
3PVVX-ray2.00A/B411-507[»]
ProteinModelPortalA5TY69.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5TY69.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000067689; EBMYCP00000065799; EBMYCG00000067684.
GeneID5211618.
GenomeReviewsGene locus MRA_0001 in contig CP000611_GR.
KEGGmra:MRA_0001.
PATRIC18139552. VBIMycTub106795_0001.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0593.
GeneTreeEBGT00050000017320.
HOGENOMHBG695666.
OMAASVHESW.
ProtClustDBPRK00149.

Enzyme and pathway databases

BioCycMTUB419947:MRA_0001-MONOMER.

Family and domain databases

HAMAPMF_00377. DnaA_bact.
[Tree]
InterProIPR003593. ATPase_AAA+_core.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
Gene3DG3DSA:1.10.1750.10. DnaA_C. 1 hit.
KOK02313.
PfamPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSPR00051. DNAA.
SMARTSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMSSF48295. Trp_repress_rep. 1 hit.
TIGRFAMsTIGR00362. DnaA. 1 hit.
PROSITEPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAA_MYCTA
AccessionPrimary (citable) accession number: A5TY69
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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