A5TRD3 (A5TRD3_BURMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide deformylase 2 HAMAP MF_00163
Short name=PDF 2 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163

Alternative name(s):
Polypeptide deformylase 2 HAMAP MF_00163

Gene names

Name:	def-1 EMBL EDK87452.1
Synonyms:	def2 HAMAP MF_00163
ORF Names:	BMA721280_C0028 EMBL EDK87452.1

Organism

Burkholderia mallei 2002721280 EMBL EDK87452.1

Taxonomic identifier

370895 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163
Catalytic activity	Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 SAAS SAAS000181
Cofactor	Binds 1 Fe2+ ion By similarity. HAMAP MF_00163
Sequence similarities	Belongs to the polypeptide deformylase family. HAMAP MF_00163 RuleBase RU003335

Ontologies

Keywords
Biological process	Protein biosynthesis HAMAP MF_00163 SAAS SAAS000181
Ligand	Iron HAMAP MF_00163 Metal-binding HAMAP MF_00163 SAAS SAAS000181
Molecular function	Hydrolase HAMAP MF_00163 SAAS SAAS000181 EMBL EDK87452.1
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro peptide deformylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	135	1	By similarity HAMAP MF_00163
	Metal binding	92	1	Iron By similarity HAMAP MF_00163
	Metal binding	134	1	Iron By similarity HAMAP MF_00163
	Metal binding	138	1	Iron By similarity HAMAP MF_00163

Sequences

	Sequence		Length	Mass (Da)
	A5TRD3 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: F1D525AB88D989A7	FASTA	167	18,971
	10 20 30 40 50 60 MALLNILHYP DKRLHKVAKP VAKVDDRIRK LVADMAETMY AAPGIGLAAT QVDVHERVIV 70 80 90 100 110 120 IDVSEDKNEL RVFINPEIVW TGDGKQVYEE GCLSVPGVYD EVERPDRVRV RALDGQGESF 130 140 150 160 ELDCEGLLAV CIQHEMDHLM GRVFVQYLSP LKQTRIKTKM KKLERAM

References

[1]	"Annotation of Burkholderia mallei 2002721280." DeShazer D., Woods D.E., Nierman W.C. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 2002721280 EMBL EDK87452.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH899697 Genomic DNA. Translation: EDK87452.1.
3D structure databases
ProteinModelPortal	A5TRD3.
SMR	A5TRD3. Positions 1-165.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26897326. VBIBurMal4978_5387.
Phylogenomic databases
OMA	GVLFVDY.
Family and domain databases
HAMAP	MF_00163. Pep_deformylase. [Tree]
InterPro	IPR000181. Fmet_deformylase. IPR023635. Peptide_deformylase. [Graphical view]
Gene3D	G3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
PANTHER	PTHR10458. Fmet_deformylase. 1 hit.
Pfam	PF01327. Pep_deformylase. 1 hit. [Graphical view]
PIRSF	PIRSF004749. Pep_def. 1 hit.
PRINTS	PR01576. PDEFORMYLASE.
SUPFAM	SSF56420. Fmet_deformylase. 1 hit.
TIGRFAMs	TIGR00079. Pept_deformyl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5TRD3_BURMA

Accession

Primary (citable) accession number: A5TRD3

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)