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A5TNF9

- A5TNF9_BURML

UniProt

A5TNF9 - A5TNF9_BURML

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Protein

Pyruvate dehydrogenase E1 component

Gene

BMA721280_I0360

Organism
Burkholderia mallei 2002721280
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate.UniRule annotation

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

PyruvateUniRule annotation, Thiamine pyrophosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
ORF Names:BMA721280_I0360Imported
OrganismiBurkholderia mallei 2002721280Imported
Taxonomic identifieri370895 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiapseudomallei group

Structurei

3D structure databases

ProteinModelPortaliA5TNF9.
SMRiA5TNF9. Positions 69-897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR017600. Alpha-ketoglut_DH.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.
TIGR03186. AKGDH_not_PDH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5TNF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDLSNGIRP VLATARRHDD TDPQETAEWL DALDGVVAHA GAERAQYLLA
60 70 80 90 100
QLAEHAARRR LAPPHAGATP YVNTIPVDEE PPYPGDLQLE ERLAAVLRWN
110 120 130 140 150
ALAMVVRANR AYGELGGHIA SYASAADLFE VGFNHFFRAA GDASGGDLVY
160 170 180 190 200
FQPHSSPGVY ARAFLEGFLS DAQLEHYRRE IAGPGLCSYP HPWLMPDFWQ
210 220 230 240 250
FPTGSMGIGP INAIYQARFM RYLQNRGLLR TEGRKVWGFF GDGEMDEPES
260 270 280 290 300
IGALSLAARE GLDNLVFVIN CNLQRLDGPV RGNGRIVDEL ESQFAGAGWN
310 320 330 340 350
VIKVLWGSDW DALFARDATG ALARAFAQTV DGQFQTFSAN DGAYNRARFF
360 370 380 390 400
GQNDALAALV AHLRDEDIDR LRRGGHDARK LYAAYERAVR HEGRPTVILA
410 420 430 440 450
KTMKGFGLGA IGQGRMTTHQ QKKLDVEHLL AFRDRFRLPL TDEDVAQLRF
460 470 480 490 500
YRPEKDSPEM RYLHARRAAL GGCLPRRRAA ATAALTVPSL PSWGQFALDG
510 520 530 540 550
GREMSTTMAI VRMLGGLLKD AALGPRIVPI VADEARTFGM ANLFRQVGIY
560 570 580 590 600
SPLGQRYEPE DLGSMLYYRE DTRGQILEEG ISEAGAISSW IAAATSYSVH
610 620 630 640 650
DLPMLPFYIY YSMFGFQRIG DLIWAAADQR ARGFLIGATS GKTTLGGEGL
660 670 680 690 700
QHQDGTSHLA ASTVPNCRAW DPAFAYEIAV IVDEGMREMV ERQRDTFYYL
710 720 730 740 750
TVTNENHAQP TLPADRLDAV RGGILKGMYP LDAAALPAAR VQLLGSGAIL
760 770 780 790 800
GEVQAAARLL RDDWRIDAAV WSVTSFTELQ RDGIAAERAQ RLFDADDANE
810 820 830 840 850
RSPTPHVTSA LAATQGPVIA ATDYARALPE LIRAYVPRRY VTLGTDGFGR
860 870 880 890 900
SDTREALRAF FEVDRGSIVI AALRALADDG EVTRTVVRDA IARYGKRDAS

RTPPWER
Length:907
Mass (Da):99,904
Last modified:July 10, 2007 - v1
Checksum:iF9297894299BDEEA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH899695 Genomic DNA. Translation: EDK86428.1.

Genome annotation databases

EnsemblBacteriaiEDK86428; EDK86428; BMA721280_I0360.
PATRICi26895019. VBIBurMal4978_4497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH899695 Genomic DNA. Translation: EDK86428.1 .

3D structure databases

ProteinModelPortali A5TNF9.
SMRi A5TNF9. Positions 69-897.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK86428 ; EDK86428 ; BMA721280_I0360 .
PATRICi 26895019. VBIBurMal4978_4497.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR017600. Alpha-ketoglut_DH.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
TIGR03186. AKGDH_not_PDH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Annotation of Burkholderia mallei 2002721280."
    DeShazer D., Woods D.E., Nierman W.C.
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2002721280Imported.

Entry informationi

Entry nameiA5TNF9_BURML
AccessioniPrimary (citable) accession number: A5TNF9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)