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A5TK41 (A5TK41_BURMA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183 EMBL EDK85260.1
ORF Names:BMA721280_A0977 EMBL EDK85260.1
OrganismBurkholderia mallei 2002721280 EMBL EDK85260.1
Taxonomic identifier370895 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding8 – 3730NADP By similarity HAMAP MF_00183

Sites

Metal binding1511Divalent metal cation By similarity HAMAP MF_00183
Metal binding1531Divalent metal cation By similarity HAMAP MF_00183
Metal binding2241Divalent metal cation By similarity HAMAP MF_00183
Binding site1261Substrate By similarity HAMAP MF_00183
Binding site1531Substrate By similarity HAMAP MF_00183
Binding site1791Substrate By similarity HAMAP MF_00183
Binding site2021Substrate By similarity HAMAP MF_00183
Binding site2241Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A5TK41 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 6500410CBCAA8463

FASTA39841,622
        10         20         30         40         50         60 
MQKRLTLLGS TGSIGDSTLD VVARHPERFA VHALTAHRNG EKLVAQCLRF APDVAVVGDA 

        70         80         90        100        110        120 
ETAARVEAQL RAAGSRTQVA YGKQALVDVS KSDGCDTVVA AIVGAAGLAP SLAAARAGKR 

       130        140        150        160        170        180 
ILLANKEALV MSGAIFMDAV RDHGAILLPV DSEHNAIFQC MPRDAAEHGG IAKIIVTASG 

       190        200        210        220        230        240 
GPFRTREPAT LASVTPDEAC KHPNWVMGRK ISVDSATMMN KGLEVIEAHW LFGLPSEHID 

       250        260        270        280        290        300 
VLIHPQSVIH SLVSYRDGSV LAQLGNPDMR TPIAHALAFP ERVDAGVAQL DLAQIATLTF 

       310        320        330        340        350        360 
EKPDYARFPC LALAIDALEA GGVASAALNA ANEIAVDAFL SRRIRFTAIA QTVGAVLDGL 

       370        380        390 
SNRTPGGLDD VIEADAAARR AATAFIGKLP APGVERAA

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References

[1]"Annotation of Burkholderia mallei 2002721280."
DeShazer D., Woods D.E., Nierman W.C.
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 2002721280 EMBL EDK85260.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH899694 Genomic DNA. Translation: EDK85260.1.

3D structure databases

ProteinModelPortalA5TK41.
SMRA5TK41. Positions 2-392.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC26892374. VBIBurMal4978_3598.

Phylogenomic databases

OMAIHSMVEY.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5TK41_BURMA
AccessionPrimary (citable) accession number: A5TK41
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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