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A5PMF6

- GT251_DANRE

UniProt

A5PMF6 - GT251_DANRE

Protein

Procollagen galactosyltransferase 1

Gene

colgalt1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.By similarity

    Catalytic activityi

    UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

    GO - Molecular functioni

    1. procollagen galactosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_222767. Collagen biosynthesis and modifying enzymes.

    Protein family/group databases

    CAZyiGT25. Glycosyltransferase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Procollagen galactosyltransferase 1 (EC:2.4.1.50)
    Alternative name(s):
    Collagen beta(1-O)galactosyltransferase 1
    Glycosyltransferase 25 family member 1
    Hydroxylysine galactosyltransferase 1
    Gene namesi
    Name:colgalt1
    Synonyms:glt25d1
    ORF Names:si:ch211-114l13.7, zgc:110667
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 1

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 604586Procollagen galactosyltransferase 1PRO_0000309538Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    BgeeiA5PMF6.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000075565.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PMF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi601 – 6044Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG293154.
    GeneTreeiENSGT00550000074427.
    HOGENOMiHOG000007198.
    HOVERGENiHBG058097.
    KOiK11703.
    OMAiMWADYIL.
    OrthoDBiEOG7060RC.
    PhylomeDBiA5PMF6.
    TreeFamiTF313826.

    Family and domain databases

    InterProiIPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01755. Glyco_transf_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5PMF6-1 [UniParc]FASTAAdd to Basket

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    MHLLCFFFLL LWTGPARSYF PEERWSPESA LLAPRVLVAL VCRNSAHSLP    50
    HVLGAIDRLN YPKDRMAVWV ATDHNSDNTT EILREWLVNV QNFYHYVEWR 100
    PQDEPSVYEG ESGPKHWTNL RYEHVMKLRQ AALETAREMW ADYFMLVDCD 150
    NLLTNRDVLW KLMRENKTIV APMLESRAAY SNFWCGMTSQ GYYKRTPAYM 200
    PIRRQERKGC FAVPMVHSTL LLDLRKEASR QLAFFPPHPD YTWAFDDIII 250
    FAFSARMAEV QMYICNRETY GYFPVPLRSQ NSLQDEAESF LHSQLEVMVR 300
    NPPIEPSVYL SLMPKQTDKM GFDEVFMINL LRRSDRRERM LRTLYEQEIA 350
    CKIITAVDGK ALNASQVEAL GIKMLPGYSD PYHGRPLTKG ELGCFLSHYN 400
    IWNEIVDRGL QSSLVIEDDL RFEVFFKRRL QNLMQEVQSQ QLDWDLIYIG 450
    RKRMQVERPE KSVPRIHSLV EADYSYWTLG YVISLRGAQK LLRAEPLKKM 500
    LPVDEFLPVM YNKHPIEEYM SHFPQRDLRA FSAEPLLIYP THYTGDQGYI 550
    SDTETSSVWD NESVLTDWDR ARSRKSREQE ELSSEAQNTD VLQSPLDSTA 600
    RDEL 604
    Length:604
    Mass (Da):70,832
    Last modified:July 10, 2007 - v1
    Checksum:i7D9556D629E4BF7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX469930 Genomic DNA. Translation: CAN87888.1.
    RefSeqiNP_001103992.1. NM_001110522.1.
    UniGeneiDr.135672.

    Genome annotation databases

    EnsembliENSDART00000081122; ENSDARP00000075565; ENSDARG00000058270.
    GeneIDi567859.
    KEGGidre:567859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX469930 Genomic DNA. Translation: CAN87888.1 .
    RefSeqi NP_001103992.1. NM_001110522.1.
    UniGenei Dr.135672.

    3D structure databases

    ProteinModelPortali A5PMF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000075565.

    Protein family/group databases

    CAZyi GT25. Glycosyltransferase Family 25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000081122 ; ENSDARP00000075565 ; ENSDARG00000058270 .
    GeneIDi 567859.
    KEGGi dre:567859.

    Phylogenomic databases

    eggNOGi NOG293154.
    GeneTreei ENSGT00550000074427.
    HOGENOMi HOG000007198.
    HOVERGENi HBG058097.
    KOi K11703.
    OMAi MWADYIL.
    OrthoDBi EOG7060RC.
    PhylomeDBi A5PMF6.
    TreeFami TF313826.

    Enzyme and pathway databases

    Reactomei REACT_222767. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 20888883.

    Gene expression databases

    Bgeei A5PMF6.

    Family and domain databases

    InterProi IPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01755. Glyco_transf_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiGT251_DANRE
    AccessioniPrimary (citable) accession number: A5PMF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3