A5PMF4 (A5PMF4_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Caspase PIRNR PIRNR038001

Gene names

Name:	caspb Ensembl ENSDARP00000114705 ZFIN ZDB-GENE-020812-1
ORF Names:	CH211-114L13.5-001 EMBL CAN87886.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL CAN87886.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C14A family. RuleBase RU003971 PIRNR PIRNR038001 Contains 1 DAPIN domain. SAAS SAAS004020

Ontologies

Keywords
Molecular function	Hydrolase Protease Thiol protease RuleBase RU003972
PTM	Zymogen RuleBase RU003972
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Inferred from electronic annotation. Source: InterPro positive regulation of apoptotic process Inferred from direct assay. Source: ZFIN proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	249	1	By similarity PIRSR PIRSR038001-1
	Active site	296	1	By similarity PIRSR PIRSR038001-1

Sequences

	Sequence		Length	Mass (Da)
	A5PMF4 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 04907822A150DD3F	FASTA	404	45,999
	10 20 30 40 50 60 MEDITQLLSD VLEDLVESEL KQFTRQLWIG VKPGVEPIPR GKLENKDRQD VVDSMVQQYS 70 80 90 100 110 120 EDAGTITVQT LRKIKQNERA KRLESNLLKV QSQGQENKQN SEEPQPIPQI ISQPIQQIIS 130 140 150 160 170 180 QPINNAGSED LQPIQADWQR PRQIIPCSQE TKNTLLKAHG DDANTPRSGT QRKGLALLIT 190 200 210 220 230 240 NIQFANTQHN RNGADRDEEN AEWLLRSLGF AVIKYRNLSG KDIRRAVENF SKRREHEDAD 250 260 270 280 290 300 STFIVIMSHG TRIDNKDAIV GVSDDVYFIE ETFSHLNSVN CPALIDKPKV ILIQACRGGQ 310 320 330 340 350 360 SSGVLAQDSV FASDSWVHME KDFVCFMSTM PNTFAYRNPI EGSFFISYIV DVFCSSAHRD 370 380 390 400 DIMELFRKVT LRMEKDQRFQ GQAKLLPCIE RTSISKRFYL FPGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Smith M. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000114705.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000114705.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX469930 Genomic DNA. Translation: CAN87886.1.
IPI	IPI00931147.
UniGene	Dr.81726.
3D structure databases
ProteinModelPortal	A5PMF4.
ModBase	Search...
Protein-protein interaction databases
STRING	A5PMF4.
Protein family/group databases
MEROPS	C14.031.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000136998; ENSDARP00000114705; ENSDARG00000052039.
Organism-specific databases
ZFIN	ZDB-GENE-020812-1. caspb.
Phylogenomic databases
HOVERGEN	HBG076981.
Gene expression databases
Bgee	A5PMF4.
Family and domain databases
InterPro	IPR017350. Caspase_IL-1_beta. IPR011029. DEATH-like. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. IPR004020. Pyrin. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
PANTHER	PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF02758. PAAD_DAPIN. 1 hit. PF00656. Peptidase_C14. 1 hit. [Graphical view]
PIRSF	PIRSF038001. Caspase_ICE. 1 hit.
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00115. CASc. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. PS50824. DAPIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5PMF4_DANRE

Accession

Primary (citable) accession number: A5PMF4

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)