A5PLN9 (TPC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trafficking protein particle complex subunit 13

Gene names

Name:	TRAPPC13
Synonyms:	C5orf44

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Part of the multisubunit TRAPP (transport protein particle) complex. Ref.7
Sequence similarities	Belongs to the TRAPPC13 family.
Sequence caution	The sequence AAH47475.1 differs from that shown. Reason: Wrong choice of CDS. The sequence BAB14633.1 differs from that shown. Reason: Erroneous termination at position 63. Translated as Glu.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A5PLN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A5PLN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.

Isoform 3 (identifier: A5PLN9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     332-332: C → CS

Isoform 4 (identifier: A5PLN9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     332-332: C → CS

Isoform 5 (identifier: A5PLN9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     300-315: APGYGDVRLSLEAIPD → VSLEKTSLGFWCVKDR
     316-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Trafficking protein particle complex subunit 13		PRO_0000321547
Natural variations
	Alternative sequence	183 – 188	6	Missing in isoform 2, isoform 3 and isoform 5.		VSP_038356
	Alternative sequence	300 – 315	16	APGYG…EAIPD → VSLEKTSLGFWCVKDR in isoform 5.		VSP_038357
	Alternative sequence	316 – 417	102	Missing in isoform 5.		VSP_038358
	Alternative sequence	332	1	C → CS in isoform 3 and isoform 4.		VSP_038359
Experimental info
	Sequence conflict	177	1	K → R in AAY88966. Ref.6
	Sequence conflict	255	1	L → P in AAY88966. Ref.6
	Sequence conflict	403	1	I → V in AAI42995. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 7E80D7B11511DC6E	FASTA	417	46,524
	10 20 30 40 50 60 MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 70 80 90 100 110 120 LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 130 140 150 160 170 180 ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 190 200 210 220 230 240 AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR 250 260 270 280 290 300 AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA 310 320 330 340 350 360 PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH WCGISGRQLG 370 380 390 400 410 KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY DDIAQVCVVS SAIKVES
	Isoform 2 [UniParc]. Checksum: 4F8957F04D4ADDC8	FASTA	411	45,935
	10 20 30 40 50 60 MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 70 80 90 100 110 120 LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 130 140 150 160 170 180 ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 190 200 210 220 230 240 AETDEVFLEA QIQNMTTSPM FMEKVSLEPS IMYNVTELNS VSQAGECVST FGSRAYLQPM 250 260 270 280 290 300 DTRQYLYCLK PKNEFAEKAG IIKGVTVIGK LDIVWKTNLG ERGRLQTSQL QRMAPGYGDV 310 320 330 340 350 360 RLSLEAIPDT VNLEEPFHIT CKITNCSERT MDLVLEMCNT NSIHWCGISG RQLGKLHPSS 370 380 390 400 410 SLCLALTLLS SVQGLQSISG LRLTDTFLKR TYEYDDIAQV CVVSSAIKVE S
	Isoform 3 [UniParc]. Checksum: 4C9D6D1C407AD42B	FASTA	412	46,022
	10 20 30 40 50 60 MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 70 80 90 100 110 120 LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 130 140 150 160 170 180 ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 190 200 210 220 230 240 AETDEVFLEA QIQNMTTSPM FMEKVSLEPS IMYNVTELNS VSQAGECVST FGSRAYLQPM 250 260 270 280 290 300 DTRQYLYCLK PKNEFAEKAG IIKGVTVIGK LDIVWKTNLG ERGRLQTSQL QRMAPGYGDV 310 320 330 340 350 360 RLSLEAIPDT VNLEEPFHIT CKITNCSSER TMDLVLEMCN TNSIHWCGIS GRQLGKLHPS 370 380 390 400 410 SSLCLALTLL SSVQGLQSIS GLRLTDTFLK RTYEYDDIAQ VCVVSSAIKV ES
	Isoform 4 [UniParc]. Checksum: A70C649C01228F2A	FASTA	418	46,611
	10 20 30 40 50 60 MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 70 80 90 100 110 120 LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 130 140 150 160 170 180 ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 190 200 210 220 230 240 AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR 250 260 270 280 290 300 AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA 310 320 330 340 350 360 PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSSERTMDL VLEMCNTNSI HWCGISGRQL 370 380 390 400 410 GKLHPSSSLC LALTLLSSVQ GLQSISGLRL TDTFLKRTYE YDDIAQVCVV SSAIKVES
	Isoform 5 [UniParc]. Checksum: D7AE8E83451A6FBE	FASTA	309	34,884
	10 20 30 40 50 60 MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 70 80 90 100 110 120 LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 130 140 150 160 170 180 ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 190 200 210 220 230 240 AETDEVFLEA QIQNMTTSPM FMEKVSLEPS IMYNVTELNS VSQAGECVST FGSRAYLQPM 250 260 270 280 290 300 DTRQYLYCLK PKNEFAEKAG IIKGVTVIGK LDIVWKTNLG ERGRLQTSQL QRMVSLEKTS LGFWCVKDR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-417 (ISOFORM 1). Tissue: Brain and Small intestine.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-417 (ISOFORM 2). Tissue: Brain.
[6]	Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-417 (ISOFORM 4).
[7]	"Organization and assembly of the TRAPPII complex." Choi C., Davey M., Schluter C., Pandher P., Fang Y., Foster L.J., Conibear E. Traffic 12:715-725(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN TRAPP COMPLEX.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL713699 mRNA. Translation: CAD28498.1. BX641157 mRNA. Translation: CAE46070.1. AK023673 mRNA. Translation: BAB14633.1. Sequence problems. AC008560 Genomic DNA. No translation available. CH471137 Genomic DNA. Translation: EAW51346.1. BC047475 mRNA. Translation: AAH47475.1. Sequence problems. BC117128 mRNA. Translation: AAI17129.1. BC142994 mRNA. Translation: AAI42995.1. DQ088673 mRNA. Translation: AAY88966.1.
IPI	IPI00847958. IPI00848035. IPI00872709. IPI00884972. IPI00885084.
RefSeq	NP_001087224.1. NM_001093755.1. NP_001087225.1. NM_001093756.1. NP_001230666.1. NM_001243737.1. NP_079217.2. NM_024941.3.
UniGene	Hs.591760.
3D structure databases
ProteinModelPortal	A5PLN9.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48284N.
IntAct	A5PLN9. 1 interaction.
STRING	9606.ENSP00000409231.
PTM databases
PhosphoSite	A5PLN9.
Proteomic databases
PaxDb	A5PLN9.
PRIDE	A5PLN9.
Protocols and materials databases
DNASU	80006.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000231526; ENSP00000231526; ENSG00000113597. ENST00000399438; ENSP00000382367; ENSG00000113597. ENST00000438419; ENSP00000409231; ENSG00000113597. ENST00000505553; ENSP00000423405; ENSG00000113597.
GeneID	80006.
KEGG	hsa:80006.
UCSC	uc003jtz.4. human. uc003jua.4. human. uc003juc.4. human. uc010iwv.3. human.
Organism-specific databases
CTD	80006.
GeneCards	GC05P064922.
H-InvDB	HIX0018533.
HGNC	HGNC:25828. TRAPPC13.
HPA	HPA037777.
neXtProt	NX_A5PLN9.
PharmGKB	PA162380280.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG282912.
HOGENOM	HOG000029668.
HOVERGEN	HBG107638.
InParanoid	A5PLN9.
OrthoDB	EOG47PX62.
Gene expression databases
ArrayExpress	A5PLN9.
Bgee	A5PLN9.
CleanEx	HS_C5orf44.
Genevestigator	A5PLN9.
Family and domain databases
InterPro	IPR010378. DUF974. [Graphical view]
PANTHER	PTHR13134. PTHR13134. 1 hit.
Pfam	PF06159. DUF974. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80006.
NextBio	70087.

Entry information

Entry name

TPC13_HUMAN

Accession

Primary (citable) accession number: A5PLN9
Secondary accession number(s): Q17RZ9 , Q49A23, Q4JHG0, Q6MZG4, Q8TCM2, Q9H8I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.