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Protein

Trafficking protein particle complex subunit 13

Gene

TRAPPC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 13
Gene namesi
Name:TRAPPC13
Synonyms:C5orf44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25828. TRAPPC13.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113597.
PharmGKBiPA162380280.

Polymorphism and mutation databases

BioMutaiTRAPPC13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215471 – 417Trafficking protein particle complex subunit 13Add BLAST417

Proteomic databases

MaxQBiA5PLN9.
PaxDbiA5PLN9.
PRIDEiA5PLN9.

PTM databases

iPTMnetiA5PLN9.
PhosphoSitePlusiA5PLN9.

Expressioni

Gene expression databases

BgeeiENSG00000113597.
CleanExiHS_C5orf44.
ExpressionAtlasiA5PLN9. baseline and differential.
GenevisibleiA5PLN9. HS.

Organism-specific databases

HPAiHPA037777.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC3O436172EBI-2857298,EBI-743566
TRAPPC8Q9Y2L52EBI-2857298,EBI-2820056

Protein-protein interaction databases

BioGridi123063. 23 interactors.
DIPiDIP-48284N.
IntActiA5PLN9. 16 interactors.
STRINGi9606.ENSP00000409231.

Structurei

3D structure databases

ProteinModelPortaliA5PLN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAPPC13 family.Curated

Phylogenomic databases

eggNOGiKOG2625. Eukaryota.
ENOG410XSJK. LUCA.
GeneTreeiENSGT00390000015280.
HOGENOMiHOG000029668.
HOVERGENiHBG107638.
InParanoidiA5PLN9.
KOiK20310.
OMAiILMLGEM.
OrthoDBiEOG091G090D.
PhylomeDBiA5PLN9.
TreeFamiTF314898.

Family and domain databases

InterProiIPR010378. DUF974.
[Graphical view]
PANTHERiPTHR13134. PTHR13134. 1 hit.
PfamiPF06159. DUF974. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5PLN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP
60 70 80 90 100
STVNGAEVLM LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK
110 120 130 140 150
ADLQTSSQRL NLSASNAAVA ELKPDCCIDD VIHHEVKEIG THILVCAVSY
160 170 180 190 200
TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN AESDLSSVTD EVFLEAQIQN
210 220 230 240 250
MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR AYLQPMDTRQ
260 270 280 290 300
YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA
310 320 330 340 350
PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH
360 370 380 390 400
WCGISGRQLG KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY
410
DDIAQVCVVS SAIKVES
Length:417
Mass (Da):46,524
Last modified:February 26, 2008 - v2
Checksum:i7E80D7B11511DC6E
GO
Isoform 2 (identifier: A5PLN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.

Show »
Length:411
Mass (Da):45,935
Checksum:i4F8957F04D4ADDC8
GO
Isoform 3 (identifier: A5PLN9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     332-332: C → CS

Show »
Length:412
Mass (Da):46,022
Checksum:i4C9D6D1C407AD42B
GO
Isoform 4 (identifier: A5PLN9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     332-332: C → CS

Show »
Length:418
Mass (Da):46,611
Checksum:iA70C649C01228F2A
GO
Isoform 5 (identifier: A5PLN9-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     300-315: APGYGDVRLSLEAIPD → VSLEKTSLGFWCVKDR
     316-417: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:309
Mass (Da):34,884
Checksum:iD7AE8E83451A6FBE
GO

Sequence cautioni

The sequence AAH47475 differs from that shown. Wrong choice of CDS.Curated
The sequence BAB14633 differs from that shown. Reason: Erroneous termination at position 63. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177K → R in AAY88966 (Ref. 6) Curated1
Sequence conflicti255L → P in AAY88966 (Ref. 6) Curated1
Sequence conflicti403I → V in AAI42995 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038356183 – 188Missing in isoform 2, isoform 3 and isoform 5. 2 Publications6
Alternative sequenceiVSP_038357300 – 315APGYG…EAIPD → VSLEKTSLGFWCVKDR in isoform 5. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_038358316 – 417Missing in isoform 5. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_038359332C → CS in isoform 3 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713699 mRNA. Translation: CAD28498.1.
BX641157 mRNA. Translation: CAE46070.1.
AK023673 mRNA. Translation: BAB14633.1. Sequence problems.
AC008560 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51346.1.
BC047475 mRNA. Translation: AAH47475.1. Sequence problems.
BC117128 mRNA. Translation: AAI17129.1.
BC142994 mRNA. Translation: AAI42995.1.
DQ088673 mRNA. Translation: AAY88966.1.
CCDSiCCDS47221.1. [A5PLN9-5]
CCDS47222.1. [A5PLN9-1]
CCDS47223.1. [A5PLN9-2]
CCDS58950.1. [A5PLN9-4]
RefSeqiNP_001087224.1. NM_001093755.1. [A5PLN9-5]
NP_001087225.1. NM_001093756.1. [A5PLN9-2]
NP_001230666.1. NM_001243737.1. [A5PLN9-4]
NP_079217.2. NM_024941.3. [A5PLN9-1]
UniGeneiHs.591760.

Genome annotation databases

EnsembliENST00000231526; ENSP00000231526; ENSG00000113597. [A5PLN9-2]
ENST00000399438; ENSP00000382367; ENSG00000113597. [A5PLN9-1]
ENST00000438419; ENSP00000409231; ENSG00000113597. [A5PLN9-5]
ENST00000505553; ENSP00000423405; ENSG00000113597. [A5PLN9-4]
GeneIDi80006.
KEGGihsa:80006.
UCSCiuc003jtz.5. human. [A5PLN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713699 mRNA. Translation: CAD28498.1.
BX641157 mRNA. Translation: CAE46070.1.
AK023673 mRNA. Translation: BAB14633.1. Sequence problems.
AC008560 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51346.1.
BC047475 mRNA. Translation: AAH47475.1. Sequence problems.
BC117128 mRNA. Translation: AAI17129.1.
BC142994 mRNA. Translation: AAI42995.1.
DQ088673 mRNA. Translation: AAY88966.1.
CCDSiCCDS47221.1. [A5PLN9-5]
CCDS47222.1. [A5PLN9-1]
CCDS47223.1. [A5PLN9-2]
CCDS58950.1. [A5PLN9-4]
RefSeqiNP_001087224.1. NM_001093755.1. [A5PLN9-5]
NP_001087225.1. NM_001093756.1. [A5PLN9-2]
NP_001230666.1. NM_001243737.1. [A5PLN9-4]
NP_079217.2. NM_024941.3. [A5PLN9-1]
UniGeneiHs.591760.

3D structure databases

ProteinModelPortaliA5PLN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123063. 23 interactors.
DIPiDIP-48284N.
IntActiA5PLN9. 16 interactors.
STRINGi9606.ENSP00000409231.

PTM databases

iPTMnetiA5PLN9.
PhosphoSitePlusiA5PLN9.

Polymorphism and mutation databases

BioMutaiTRAPPC13.

Proteomic databases

MaxQBiA5PLN9.
PaxDbiA5PLN9.
PRIDEiA5PLN9.

Protocols and materials databases

DNASUi80006.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231526; ENSP00000231526; ENSG00000113597. [A5PLN9-2]
ENST00000399438; ENSP00000382367; ENSG00000113597. [A5PLN9-1]
ENST00000438419; ENSP00000409231; ENSG00000113597. [A5PLN9-5]
ENST00000505553; ENSP00000423405; ENSG00000113597. [A5PLN9-4]
GeneIDi80006.
KEGGihsa:80006.
UCSCiuc003jtz.5. human. [A5PLN9-1]

Organism-specific databases

CTDi80006.
GeneCardsiTRAPPC13.
H-InvDBHIX0018533.
HGNCiHGNC:25828. TRAPPC13.
HPAiHPA037777.
neXtProtiNX_A5PLN9.
OpenTargetsiENSG00000113597.
PharmGKBiPA162380280.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2625. Eukaryota.
ENOG410XSJK. LUCA.
GeneTreeiENSGT00390000015280.
HOGENOMiHOG000029668.
HOVERGENiHBG107638.
InParanoidiA5PLN9.
KOiK20310.
OMAiILMLGEM.
OrthoDBiEOG091G090D.
PhylomeDBiA5PLN9.
TreeFamiTF314898.

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

GenomeRNAii80006.
PROiA5PLN9.

Gene expression databases

BgeeiENSG00000113597.
CleanExiHS_C5orf44.
ExpressionAtlasiA5PLN9. baseline and differential.
GenevisibleiA5PLN9. HS.

Family and domain databases

InterProiIPR010378. DUF974.
[Graphical view]
PANTHERiPTHR13134. PTHR13134. 1 hit.
PfamiPF06159. DUF974. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPC13_HUMAN
AccessioniPrimary (citable) accession number: A5PLN9
Secondary accession number(s): Q17RZ9
, Q49A23, Q4JHG0, Q6MZG4, Q8TCM2, Q9H8I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.