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A5PLN9 (TPC13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trafficking protein particle complex subunit 13
Gene names
Name:TRAPPC13
Synonyms:C5orf44
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Part of the multisubunit TRAPP (transport protein particle) complex. Ref.7

Sequence similarities

Belongs to the TRAPPC13 family.

Sequence caution

The sequence AAH47475.1 differs from that shown. Reason: Wrong choice of CDS.

The sequence BAB14633.1 differs from that shown. Reason: Erroneous termination at position 63. Translated as Glu.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction Ref.7. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRAPPC3O436172EBI-2857298,EBI-743566
TRAPPC8Q9Y2L52EBI-2857298,EBI-2820056

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A5PLN9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A5PLN9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
Isoform 3 (identifier: A5PLN9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     332-332: C → CS
Isoform 4 (identifier: A5PLN9-5)

The sequence of this isoform differs from the canonical sequence as follows:
     332-332: C → CS
Isoform 5 (identifier: A5PLN9-7)

The sequence of this isoform differs from the canonical sequence as follows:
     183-188: Missing.
     300-315: APGYGDVRLSLEAIPD → VSLEKTSLGFWCVKDR
     316-417: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Trafficking protein particle complex subunit 13
PRO_0000321547

Natural variations

Alternative sequence183 – 1886Missing in isoform 2, isoform 3 and isoform 5.
VSP_038356
Alternative sequence300 – 31516APGYG…EAIPD → VSLEKTSLGFWCVKDR in isoform 5.
VSP_038357
Alternative sequence316 – 417102Missing in isoform 5.
VSP_038358
Alternative sequence3321C → CS in isoform 3 and isoform 4.
VSP_038359

Experimental info

Sequence conflict1771K → R in AAY88966. Ref.6
Sequence conflict2551L → P in AAY88966. Ref.6
Sequence conflict4031I → V in AAI42995. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 7E80D7B11511DC6E

FASTA41746,524
        10         20         30         40         50         60 
MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP STVNGAEVLM 

        70         80         90        100        110        120 
LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK ADLQTSSQRL NLSASNAAVA 

       130        140        150        160        170        180 
ELKPDCCIDD VIHHEVKEIG THILVCAVSY TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN 

       190        200        210        220        230        240 
AESDLSSVTD EVFLEAQIQN MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR 

       250        260        270        280        290        300 
AYLQPMDTRQ YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA 

       310        320        330        340        350        360 
PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH WCGISGRQLG 

       370        380        390        400        410 
KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY DDIAQVCVVS SAIKVES 

« Hide

Isoform 2 [UniParc].

Checksum: 4F8957F04D4ADDC8
Show »

FASTA41145,935
Isoform 3 [UniParc].

Checksum: 4C9D6D1C407AD42B
Show »

FASTA41246,022
Isoform 4 [UniParc].

Checksum: A70C649C01228F2A
Show »

FASTA41846,611
Isoform 5 [UniParc].

Checksum: D7AE8E83451A6FBE
Show »

FASTA30934,884

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-417 (ISOFORM 1).
Tissue: Brain and Small intestine.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-417 (ISOFORM 2).
Tissue: Brain.
[6]Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-417 (ISOFORM 4).
[7]"Organization and assembly of the TRAPPII complex."
Choi C., Davey M., Schluter C., Pandher P., Fang Y., Foster L.J., Conibear E.
Traffic 12:715-725(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL713699 mRNA. Translation: CAD28498.1.
BX641157 mRNA. Translation: CAE46070.1.
AK023673 mRNA. Translation: BAB14633.1. Sequence problems.
AC008560 Genomic DNA. No translation available.
CH471137 Genomic DNA. Translation: EAW51346.1.
BC047475 mRNA. Translation: AAH47475.1. Sequence problems.
BC117128 mRNA. Translation: AAI17129.1.
BC142994 mRNA. Translation: AAI42995.1.
DQ088673 mRNA. Translation: AAY88966.1.
CCDSCCDS47221.1. [A5PLN9-5]
CCDS47222.1. [A5PLN9-1]
CCDS47223.1. [A5PLN9-2]
CCDS58950.1. [A5PLN9-4]
RefSeqNP_001087224.1. NM_001093755.1. [A5PLN9-5]
NP_001087225.1. NM_001093756.1. [A5PLN9-2]
NP_001230666.1. NM_001243737.1. [A5PLN9-4]
NP_079217.2. NM_024941.3. [A5PLN9-1]
UniGeneHs.591760.

3D structure databases

ProteinModelPortalA5PLN9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123063. 5 interactions.
DIPDIP-48284N.
IntActA5PLN9. 4 interactions.
STRING9606.ENSP00000409231.

PTM databases

PhosphoSiteA5PLN9.

Proteomic databases

MaxQBA5PLN9.
PaxDbA5PLN9.
PRIDEA5PLN9.

Protocols and materials databases

DNASU80006.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231526; ENSP00000231526; ENSG00000113597. [A5PLN9-2]
ENST00000399438; ENSP00000382367; ENSG00000113597. [A5PLN9-1]
ENST00000438419; ENSP00000409231; ENSG00000113597. [A5PLN9-5]
ENST00000505553; ENSP00000423405; ENSG00000113597. [A5PLN9-4]
GeneID80006.
KEGGhsa:80006.
UCSCuc003jtz.4. human. [A5PLN9-1]
uc003jua.4. human. [A5PLN9-5]
uc003juc.4. human. [A5PLN9-2]
uc010iwv.3. human. [A5PLN9-4]

Organism-specific databases

CTD80006.
GeneCardsGC05P064925.
H-InvDBHIX0018533.
HGNCHGNC:25828. TRAPPC13.
HPAHPA037777.
neXtProtNX_A5PLN9.
PharmGKBPA162380280.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG282912.
HOGENOMHOG000029668.
HOVERGENHBG107638.
InParanoidA5PLN9.
OrthoDBEOG7T1RBB.
PhylomeDBA5PLN9.
TreeFamTF314898.

Gene expression databases

ArrayExpressA5PLN9.
BgeeA5PLN9.
CleanExHS_C5orf44.
GenevestigatorA5PLN9.

Family and domain databases

InterProIPR010378. DUF974.
[Graphical view]
PANTHERPTHR13134. PTHR13134. 1 hit.
PfamPF06159. DUF974. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi80006.
NextBio70087.

Entry information

Entry nameTPC13_HUMAN
AccessionPrimary (citable) accession number: A5PLN9
Secondary accession number(s): Q17RZ9 expand/collapse secondary AC list , Q49A23, Q4JHG0, Q6MZG4, Q8TCM2, Q9H8I3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM