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A5PLN9

- TPC13_HUMAN

UniProt

A5PLN9 - TPC13_HUMAN

Protein

Trafficking protein particle complex subunit 13

Gene

TRAPPC13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 13
    Gene namesi
    Name:TRAPPC13
    Synonyms:C5orf44
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25828. TRAPPC13.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Trafficking protein particle complex subunit 13PRO_0000321547Add
    BLAST

    Proteomic databases

    MaxQBiA5PLN9.
    PaxDbiA5PLN9.
    PRIDEiA5PLN9.

    PTM databases

    PhosphoSiteiA5PLN9.

    Expressioni

    Gene expression databases

    ArrayExpressiA5PLN9.
    BgeeiA5PLN9.
    CleanExiHS_C5orf44.
    GenevestigatoriA5PLN9.

    Organism-specific databases

    HPAiHPA037777.

    Interactioni

    Subunit structurei

    Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRAPPC3O436172EBI-2857298,EBI-743566
    TRAPPC8Q9Y2L52EBI-2857298,EBI-2820056

    Protein-protein interaction databases

    BioGridi123063. 5 interactions.
    DIPiDIP-48284N.
    IntActiA5PLN9. 4 interactions.
    STRINGi9606.ENSP00000409231.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PLN9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TRAPPC13 family.Curated

    Phylogenomic databases

    eggNOGiNOG282912.
    HOGENOMiHOG000029668.
    HOVERGENiHBG107638.
    InParanoidiA5PLN9.
    OrthoDBiEOG7T1RBB.
    PhylomeDBiA5PLN9.
    TreeFamiTF314898.

    Family and domain databases

    InterProiIPR010378. DUF974.
    [Graphical view]
    PANTHERiPTHR13134. PTHR13134. 1 hit.
    PfamiPF06159. DUF974. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A5PLN9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVNPPKQEH LLALKVMRLT KPTLFTNIPV TCEEKDLPGD LFNQLMRDDP    50
    STVNGAEVLM LGEMLTLPQN FGNIFLGETF SSYISVHNDS NQVVKDILVK 100
    ADLQTSSQRL NLSASNAAVA ELKPDCCIDD VIHHEVKEIG THILVCAVSY 150
    TTQAGEKMYF RKFFKFQVLK PLDVKTKFYN AESDLSSVTD EVFLEAQIQN 200
    MTTSPMFMEK VSLEPSIMYN VTELNSVSQA GECVSTFGSR AYLQPMDTRQ 250
    YLYCLKPKNE FAEKAGIIKG VTVIGKLDIV WKTNLGERGR LQTSQLQRMA 300
    PGYGDVRLSL EAIPDTVNLE EPFHITCKIT NCSERTMDLV LEMCNTNSIH 350
    WCGISGRQLG KLHPSSSLCL ALTLLSSVQG LQSISGLRLT DTFLKRTYEY 400
    DDIAQVCVVS SAIKVES 417
    Length:417
    Mass (Da):46,524
    Last modified:February 26, 2008 - v2
    Checksum:i7E80D7B11511DC6E
    GO
    Isoform 2 (identifier: A5PLN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         183-188: Missing.

    Show »
    Length:411
    Mass (Da):45,935
    Checksum:i4F8957F04D4ADDC8
    GO
    Isoform 3 (identifier: A5PLN9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         183-188: Missing.
         332-332: C → CS

    Show »
    Length:412
    Mass (Da):46,022
    Checksum:i4C9D6D1C407AD42B
    GO
    Isoform 4 (identifier: A5PLN9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         332-332: C → CS

    Show »
    Length:418
    Mass (Da):46,611
    Checksum:iA70C649C01228F2A
    GO
    Isoform 5 (identifier: A5PLN9-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         183-188: Missing.
         300-315: APGYGDVRLSLEAIPD → VSLEKTSLGFWCVKDR
         316-417: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:309
    Mass (Da):34,884
    Checksum:iD7AE8E83451A6FBE
    GO

    Sequence cautioni

    The sequence AAH47475.1 differs from that shown. Reason: Wrong choice of CDS.
    The sequence BAB14633.1 differs from that shown. Reason: Erroneous termination at position 63. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti177 – 1771K → R in AAY88966. 1 PublicationCurated
    Sequence conflicti255 – 2551L → P in AAY88966. 1 PublicationCurated
    Sequence conflicti403 – 4031I → V in AAI42995. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei183 – 1886Missing in isoform 2, isoform 3 and isoform 5. 2 PublicationsVSP_038356
    Alternative sequencei300 – 31516APGYG…EAIPD → VSLEKTSLGFWCVKDR in isoform 5. 1 PublicationVSP_038357Add
    BLAST
    Alternative sequencei316 – 417102Missing in isoform 5. 1 PublicationVSP_038358Add
    BLAST
    Alternative sequencei332 – 3321C → CS in isoform 3 and isoform 4. 2 PublicationsVSP_038359

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL713699 mRNA. Translation: CAD28498.1.
    BX641157 mRNA. Translation: CAE46070.1.
    AK023673 mRNA. Translation: BAB14633.1. Sequence problems.
    AC008560 Genomic DNA. No translation available.
    CH471137 Genomic DNA. Translation: EAW51346.1.
    BC047475 mRNA. Translation: AAH47475.1. Sequence problems.
    BC117128 mRNA. Translation: AAI17129.1.
    BC142994 mRNA. Translation: AAI42995.1.
    DQ088673 mRNA. Translation: AAY88966.1.
    CCDSiCCDS47221.1. [A5PLN9-5]
    CCDS47222.1. [A5PLN9-1]
    CCDS47223.1. [A5PLN9-2]
    CCDS58950.1. [A5PLN9-4]
    RefSeqiNP_001087224.1. NM_001093755.1. [A5PLN9-5]
    NP_001087225.1. NM_001093756.1. [A5PLN9-2]
    NP_001230666.1. NM_001243737.1. [A5PLN9-4]
    NP_079217.2. NM_024941.3. [A5PLN9-1]
    UniGeneiHs.591760.

    Genome annotation databases

    EnsembliENST00000231526; ENSP00000231526; ENSG00000113597. [A5PLN9-2]
    ENST00000399438; ENSP00000382367; ENSG00000113597. [A5PLN9-1]
    ENST00000438419; ENSP00000409231; ENSG00000113597. [A5PLN9-5]
    ENST00000505553; ENSP00000423405; ENSG00000113597. [A5PLN9-4]
    GeneIDi80006.
    KEGGihsa:80006.
    UCSCiuc003jtz.4. human. [A5PLN9-1]
    uc003jua.4. human. [A5PLN9-5]
    uc003juc.4. human. [A5PLN9-2]
    uc010iwv.3. human. [A5PLN9-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL713699 mRNA. Translation: CAD28498.1 .
    BX641157 mRNA. Translation: CAE46070.1 .
    AK023673 mRNA. Translation: BAB14633.1 . Sequence problems.
    AC008560 Genomic DNA. No translation available.
    CH471137 Genomic DNA. Translation: EAW51346.1 .
    BC047475 mRNA. Translation: AAH47475.1 . Sequence problems.
    BC117128 mRNA. Translation: AAI17129.1 .
    BC142994 mRNA. Translation: AAI42995.1 .
    DQ088673 mRNA. Translation: AAY88966.1 .
    CCDSi CCDS47221.1. [A5PLN9-5 ]
    CCDS47222.1. [A5PLN9-1 ]
    CCDS47223.1. [A5PLN9-2 ]
    CCDS58950.1. [A5PLN9-4 ]
    RefSeqi NP_001087224.1. NM_001093755.1. [A5PLN9-5 ]
    NP_001087225.1. NM_001093756.1. [A5PLN9-2 ]
    NP_001230666.1. NM_001243737.1. [A5PLN9-4 ]
    NP_079217.2. NM_024941.3. [A5PLN9-1 ]
    UniGenei Hs.591760.

    3D structure databases

    ProteinModelPortali A5PLN9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123063. 5 interactions.
    DIPi DIP-48284N.
    IntActi A5PLN9. 4 interactions.
    STRINGi 9606.ENSP00000409231.

    PTM databases

    PhosphoSitei A5PLN9.

    Proteomic databases

    MaxQBi A5PLN9.
    PaxDbi A5PLN9.
    PRIDEi A5PLN9.

    Protocols and materials databases

    DNASUi 80006.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000231526 ; ENSP00000231526 ; ENSG00000113597 . [A5PLN9-2 ]
    ENST00000399438 ; ENSP00000382367 ; ENSG00000113597 . [A5PLN9-1 ]
    ENST00000438419 ; ENSP00000409231 ; ENSG00000113597 . [A5PLN9-5 ]
    ENST00000505553 ; ENSP00000423405 ; ENSG00000113597 . [A5PLN9-4 ]
    GeneIDi 80006.
    KEGGi hsa:80006.
    UCSCi uc003jtz.4. human. [A5PLN9-1 ]
    uc003jua.4. human. [A5PLN9-5 ]
    uc003juc.4. human. [A5PLN9-2 ]
    uc010iwv.3. human. [A5PLN9-4 ]

    Organism-specific databases

    CTDi 80006.
    GeneCardsi GC05P064925.
    H-InvDB HIX0018533.
    HGNCi HGNC:25828. TRAPPC13.
    HPAi HPA037777.
    neXtProti NX_A5PLN9.
    PharmGKBi PA162380280.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282912.
    HOGENOMi HOG000029668.
    HOVERGENi HBG107638.
    InParanoidi A5PLN9.
    OrthoDBi EOG7T1RBB.
    PhylomeDBi A5PLN9.
    TreeFami TF314898.

    Miscellaneous databases

    GenomeRNAii 80006.
    NextBioi 70087.

    Gene expression databases

    ArrayExpressi A5PLN9.
    Bgeei A5PLN9.
    CleanExi HS_C5orf44.
    Genevestigatori A5PLN9.

    Family and domain databases

    InterProi IPR010378. DUF974.
    [Graphical view ]
    PANTHERi PTHR13134. PTHR13134. 1 hit.
    Pfami PF06159. DUF974. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 211-417 (ISOFORM 1).
      Tissue: Brain and Small intestine.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-417 (ISOFORM 2).
      Tissue: Brain.
    6. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-417 (ISOFORM 4).
    7. Cited for: IDENTIFICATION IN TRAPP COMPLEX.

    Entry informationi

    Entry nameiTPC13_HUMAN
    AccessioniPrimary (citable) accession number: A5PLN9
    Secondary accession number(s): Q17RZ9
    , Q49A23, Q4JHG0, Q6MZG4, Q8TCM2, Q9H8I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3