ID   F149A_HUMAN             Reviewed;         773 AA.
AC   A5PLN7; B5MDB8; Q2TAN6; Q7Z2S5; Q9Y4T9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   27-MAR-2024, entry version 105.
DE   RecName: Full=Protein FAM149A;
GN   Name=FAM149A; ORFNames=MST119;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLU-332;
RP   GLU-437 AND ARG-505.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-773.
RC   TISSUE=Heart;
RA   Qin B.M., Wang X.Y., Zhao B., Liu B., Liu Y.Q., Sheng H., Hui R.T.;
RT   "Homo sapiens normal heart mRNA MST119.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-773, AND VARIANTS GLU-437 AND
RP   ARG-505.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=A5PLN7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A5PLN7-2; Sequence=VSP_031530;
CC       Name=3;
CC         IsoId=A5PLN7-3; Sequence=VSP_031532;
CC       Name=4;
CC         IsoId=A5PLN7-4; Sequence=VSP_031531;
CC   -!- SIMILARITY: Belongs to the FAM149 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI10817.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAQ13641.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAQ13641.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC104070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC110771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC110816; AAI10817.1; ALT_INIT; mRNA.
DR   EMBL; BC142992; AAI42993.1; -; mRNA.
DR   EMBL; AF173894; AAQ13641.1; ALT_SEQ; mRNA.
DR   EMBL; AL080065; CAB45695.2; -; mRNA.
DR   CCDS; CCDS34117.1; -. [A5PLN7-2]
DR   PIR; T12464; T12464.
DR   RefSeq; NP_001006656.1; NM_001006655.2. [A5PLN7-2]
DR   RefSeq; NP_056213.1; NM_015398.2. [A5PLN7-2]
DR   RefSeq; XP_016863486.1; XM_017007997.1.
DR   RefSeq; XP_016863491.1; XM_017008002.1.
DR   RefSeq; XP_016863492.1; XM_017008003.1.
DR   RefSeq; XP_016863493.1; XM_017008004.1.
DR   RefSeq; XP_016863494.1; XM_017008005.1.
DR   AlphaFoldDB; A5PLN7; -.
DR   SMR; A5PLN7; -.
DR   BioGRID; 117378; 2.
DR   IntAct; A5PLN7; 1.
DR   STRING; 9606.ENSP00000227065; -.
DR   iPTMnet; A5PLN7; -.
DR   PhosphoSitePlus; A5PLN7; -.
DR   BioMuta; FAM149A; -.
DR   jPOST; A5PLN7; -.
DR   MassIVE; A5PLN7; -.
DR   PaxDb; 9606-ENSP00000227065; -.
DR   PeptideAtlas; A5PLN7; -.
DR   ProteomicsDB; 740; -. [A5PLN7-1]
DR   ProteomicsDB; 741; -. [A5PLN7-2]
DR   ProteomicsDB; 742; -. [A5PLN7-3]
DR   ProteomicsDB; 743; -. [A5PLN7-4]
DR   Antibodypedia; 64772; 13 antibodies from 7 providers.
DR   DNASU; 25854; -.
DR   Ensembl; ENST00000227065.8; ENSP00000227065.4; ENSG00000109794.14. [A5PLN7-2]
DR   Ensembl; ENST00000502970.5; ENSP00000427155.1; ENSG00000109794.14. [A5PLN7-2]
DR   Ensembl; ENST00000503432.5; ENSP00000426835.1; ENSG00000109794.14. [A5PLN7-2]
DR   Ensembl; ENST00000514153.5; ENSP00000424380.1; ENSG00000109794.14. [A5PLN7-2]
DR   Ensembl; ENST00000706927.1; ENSP00000516649.1; ENSG00000109794.14. [A5PLN7-3]
DR   GeneID; 25854; -.
DR   KEGG; hsa:25854; -.
DR   MANE-Select; ENST00000706927.1; ENSP00000516649.1; NM_001395294.1; NP_001382223.1. [A5PLN7-3]
DR   UCSC; uc003iyt.5; human. [A5PLN7-1]
DR   AGR; HGNC:24527; -.
DR   CTD; 25854; -.
DR   DisGeNET; 25854; -.
DR   GeneCards; FAM149A; -.
DR   HGNC; HGNC:24527; FAM149A.
DR   HPA; ENSG00000109794; Tissue enhanced (liver).
DR   neXtProt; NX_A5PLN7; -.
DR   OpenTargets; ENSG00000109794; -.
DR   PharmGKB; PA162386366; -.
DR   VEuPathDB; HostDB:ENSG00000109794; -.
DR   eggNOG; ENOG502QQUG; Eukaryota.
DR   GeneTree; ENSGT00530000063727; -.
DR   HOGENOM; CLU_018180_0_0_1; -.
DR   InParanoid; A5PLN7; -.
DR   OMA; VPATRNK; -.
DR   OrthoDB; 3398187at2759; -.
DR   PhylomeDB; A5PLN7; -.
DR   TreeFam; TF330725; -.
DR   PathwayCommons; A5PLN7; -.
DR   SignaLink; A5PLN7; -.
DR   BioGRID-ORCS; 25854; 15 hits in 1148 CRISPR screens.
DR   ChiTaRS; FAM149A; human.
DR   GenomeRNAi; 25854; -.
DR   Pharos; A5PLN7; Tdark.
DR   PRO; PR:A5PLN7; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; A5PLN7; Protein.
DR   Bgee; ENSG00000109794; Expressed in oocyte and 189 other cell types or tissues.
DR   ExpressionAtlas; A5PLN7; baseline and differential.
DR   InterPro; IPR022194; DUF3719.
DR   InterPro; IPR039630; FAM149.
DR   PANTHER; PTHR31997; AGAP003710-PA; 1.
DR   PANTHER; PTHR31997:SF2; PROTEIN FAM149A; 1.
DR   Pfam; PF12516; DUF3719; 1.
DR   Genevisible; A5PLN7; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..773
FT                   /note="Protein FAM149A"
FT                   /id="PRO_0000319930"
FT   REGION          18..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..291
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031530"
FT   VAR_SEQ         227..235
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_031531"
FT   VAR_SEQ         723
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_031532"
FT   VARIANT         332
FT                   /note="K -> E (in dbSNP:rs4862650)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_039050"
FT   VARIANT         437
FT                   /note="K -> E (in dbSNP:rs4862653)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:17974005"
FT                   /id="VAR_039051"
FT   VARIANT         505
FT                   /note="H -> R (in dbSNP:rs2276924)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:17974005"
FT                   /id="VAR_039052"
FT   VARIANT         532
FT                   /note="P -> L (in dbSNP:rs2276922)"
FT                   /id="VAR_039053"
FT   VARIANT         722
FT                   /note="R -> W (in dbSNP:rs9991339)"
FT                   /id="VAR_039054"
FT   VARIANT         748
FT                   /note="L -> V (in dbSNP:rs6818265)"
FT                   /id="VAR_039055"
FT   CONFLICT        431
FT                   /note="P -> L (in Ref. 4; CAB45695)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        635
FT                   /note="R -> G (in Ref. 3; AAQ13641)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        644
FT                   /note="D -> N (in Ref. 2; AAI42993)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        730
FT                   /note="S -> G (in Ref. 4; CAB45695)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   773 AA;  82698 MW;  287183E70F1901E5 CRC64;
     MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT APTLLRALAP
     DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS PRAGKAPPQP PTPSGGGCSP
     ARLVVPARPP SGPGGVWAAL PRNPLQPGPG ERELGACVAP GAGPRTLFLT LPDIGEEGAS
     DGDSGDGEAR GLSEGRRRHG FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP
     TGAHTSWSGS ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP
     QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP LSACGHSSNI
     RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE VYHVDGKIEE YFAFDRKEDD
     DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK DAVAAEVFDH VWTNMVELLE ELIRKHWETT
     LTEGKKQRET LKVAGNRFPH VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS
     SFYSDMNGVM TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL
     SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL VQTSRSRFPP
     LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS RLRERTATLE RLSRPSTTHT
     FRQSDTPRKS SLTQMEFAAH TWTGQSILTG SQYVPKSFQR TTLTFKRRFQ VTS
//