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Protein

Protein FAM149A

Gene

FAM149A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM149A
Gene namesi
Name:FAM149A
ORF Names:MST119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24527. FAM149A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Protein FAM149APRO_0000319930Add
BLAST

Proteomic databases

PaxDbiA5PLN7.
PRIDEiA5PLN7.

PTM databases

PhosphoSiteiA5PLN7.

Expressioni

Gene expression databases

BgeeiA5PLN7.
CleanExiHS_FAM149A.
ExpressionAtlasiA5PLN7. baseline and differential.
GenevestigatoriA5PLN7.

Organism-specific databases

HPAiHPA055004.

Structurei

3D structure databases

ProteinModelPortaliA5PLN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 374Poly-Ala
Compositional biasi98 – 14952Pro-richAdd
BLAST
Compositional biasi228 – 28154Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM149 family.Curated

Phylogenomic databases

eggNOGiNOG27759.
GeneTreeiENSGT00530000063727.
HOGENOMiHOG000112437.
HOVERGENiHBG107111.
InParanoidiA5PLN7.
OMAiQRPTYFA.
OrthoDBiEOG7R8319.
PhylomeDBiA5PLN7.
TreeFamiTF330725.

Family and domain databases

InterProiIPR022194. DUF3719.
[Graphical view]
PfamiPF12516. DUF3719. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A5PLN7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT
60 70 80 90 100
APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS
110 120 130 140 150
PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG
160 170 180 190 200
ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG
210 220 230 240 250
FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS
260 270 280 290 300
ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP
310 320 330 340 350
QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP
360 370 380 390 400
LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE
410 420 430 440 450
VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK
460 470 480 490 500
DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH
510 520 530 540 550
VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM
560 570 580 590 600
TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL
610 620 630 640 650
SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL
660 670 680 690 700
VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS
710 720 730 740 750
RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG
760 770
SQYVPKSFQR TTLTFKRRFQ VTS
Length:773
Mass (Da):82,698
Last modified:February 26, 2008 - v2
Checksum:i287183E70F1901E5
GO
Isoform 2 (identifier: A5PLN7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.

Show »
Length:482
Mass (Da):53,250
Checksum:i7B976B1F92E4661C
GO
Isoform 3 (identifier: A5PLN7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-723: Missing.

Show »
Length:772
Mass (Da):82,569
Checksum:iA82BA8F493E45281
GO
Isoform 4 (identifier: A5PLN7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-235: Missing.

Note: No experimental confirmation available.

Show »
Length:764
Mass (Da):81,787
Checksum:i1F673FAE56038E4F
GO

Sequence cautioni

The sequence AAI10817.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAQ13641.1 differs from that shown. Reason: Frameshift at position 635. Curated
The sequence AAQ13641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4311P → L in CAB45695. (PubMed:17974005)Curated
Sequence conflicti635 – 6351R → G in AAQ13641. 1 PublicationCurated
Sequence conflicti644 – 6441D → N in AAI42993. (PubMed:15489334)Curated
Sequence conflicti730 – 7301S → G in CAB45695. (PubMed:17974005)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321K → E.1 Publication
Corresponds to variant rs4862650 [ dbSNP | Ensembl ].
VAR_039050
Natural varianti437 – 4371K → E.2 Publications
Corresponds to variant rs4862653 [ dbSNP | Ensembl ].
VAR_039051
Natural varianti505 – 5051H → R.2 Publications
Corresponds to variant rs2276924 [ dbSNP | Ensembl ].
VAR_039052
Natural varianti532 – 5321P → L.
Corresponds to variant rs2276922 [ dbSNP | Ensembl ].
VAR_039053
Natural varianti722 – 7221R → W.
Corresponds to variant rs9991339 [ dbSNP | Ensembl ].
VAR_039054
Natural varianti748 – 7481L → V.
Corresponds to variant rs6818265 [ dbSNP | Ensembl ].
VAR_039055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 291291Missing in isoform 2. 1 PublicationVSP_031530Add
BLAST
Alternative sequencei227 – 2359Missing in isoform 4. CuratedVSP_031531
Alternative sequencei723 – 7231Missing in isoform 3. CuratedVSP_031532

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSiCCDS34117.1. [A5PLN7-2]
PIRiT12464.
RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_005262961.1. XM_005262904.2. [A5PLN7-1]
XP_005262962.1. XM_005262905.2. [A5PLN7-3]
XP_005262963.1. XM_005262906.2. [A5PLN7-4]
UniGeneiHs.744961.

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneIDi25854.
KEGGihsa:25854.
UCSCiuc003iyt.4. human. [A5PLN7-1]
uc010isj.2. human. [A5PLN7-2]
uc011clb.2. human. [A5PLN7-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSiCCDS34117.1. [A5PLN7-2]
PIRiT12464.
RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_005262961.1. XM_005262904.2. [A5PLN7-1]
XP_005262962.1. XM_005262905.2. [A5PLN7-3]
XP_005262963.1. XM_005262906.2. [A5PLN7-4]
UniGeneiHs.744961.

3D structure databases

ProteinModelPortaliA5PLN7.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA5PLN7.

Proteomic databases

PaxDbiA5PLN7.
PRIDEiA5PLN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneIDi25854.
KEGGihsa:25854.
UCSCiuc003iyt.4. human. [A5PLN7-1]
uc010isj.2. human. [A5PLN7-2]
uc011clb.2. human. [A5PLN7-3]

Organism-specific databases

CTDi25854.
GeneCardsiGC04P187026.
H-InvDBHIX0031434.
HGNCiHGNC:24527. FAM149A.
HPAiHPA055004.
neXtProtiNX_A5PLN7.
PharmGKBiPA162386366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG27759.
GeneTreeiENSGT00530000063727.
HOGENOMiHOG000112437.
HOVERGENiHBG107111.
InParanoidiA5PLN7.
OMAiQRPTYFA.
OrthoDBiEOG7R8319.
PhylomeDBiA5PLN7.
TreeFamiTF330725.

Miscellaneous databases

GenomeRNAii25854.
NextBioi47208.
PROiA5PLN7.

Gene expression databases

BgeeiA5PLN7.
CleanExiHS_FAM149A.
ExpressionAtlasiA5PLN7. baseline and differential.
GenevestigatoriA5PLN7.

Family and domain databases

InterProiIPR022194. DUF3719.
[Graphical view]
PfamiPF12516. DUF3719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-332; GLU-437 AND ARG-505.
    Tissue: Brain.
  3. "Homo sapiens normal heart mRNA MST119."
    Qin B.M., Wang X.Y., Zhao B., Liu B., Liu Y.Q., Sheng H., Hui R.T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-773.
    Tissue: Heart.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-773, VARIANTS GLU-437 AND ARG-505.
    Tissue: Brain.

Entry informationi

Entry nameiF149A_HUMAN
AccessioniPrimary (citable) accession number: A5PLN7
Secondary accession number(s): B5MDB8
, Q2TAN6, Q7Z2S5, Q9Y4T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.