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Protein

Protein FAM149A

Gene

FAM149A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM149A
Gene namesi
Name:FAM149A
ORF Names:MST119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24527. FAM149A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109794.
PharmGKBiPA162386366.

Polymorphism and mutation databases

BioMutaiFAM149A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003199301 – 773Protein FAM149AAdd BLAST773

Proteomic databases

PaxDbiA5PLN7.
PRIDEiA5PLN7.

PTM databases

iPTMnetiA5PLN7.
PhosphoSitePlusiA5PLN7.

Expressioni

Gene expression databases

BgeeiENSG00000109794.
CleanExiHS_FAM149A.
ExpressionAtlasiA5PLN7. baseline and differential.
GenevisibleiA5PLN7. HS.

Organism-specific databases

HPAiHPA055004.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000227065.

Structurei

3D structure databases

ProteinModelPortaliA5PLN7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 37Poly-Ala4
Compositional biasi98 – 149Pro-richAdd BLAST52
Compositional biasi228 – 281Ser-richAdd BLAST54

Sequence similaritiesi

Belongs to the FAM149 family.Curated

Phylogenomic databases

eggNOGiENOG410IE96. Eukaryota.
ENOG410ZYXN. LUCA.
GeneTreeiENSGT00530000063727.
HOGENOMiHOG000112437.
HOVERGENiHBG107111.
InParanoidiA5PLN7.
OMAiRSSIYSW.
OrthoDBiEOG091G05T8.
PhylomeDBiA5PLN7.
TreeFamiTF330725.

Family and domain databases

InterProiIPR022194. DUF3719.
[Graphical view]
PfamiPF12516. DUF3719. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5PLN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT
60 70 80 90 100
APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS
110 120 130 140 150
PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG
160 170 180 190 200
ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG
210 220 230 240 250
FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS
260 270 280 290 300
ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP
310 320 330 340 350
QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP
360 370 380 390 400
LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE
410 420 430 440 450
VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK
460 470 480 490 500
DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH
510 520 530 540 550
VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM
560 570 580 590 600
TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL
610 620 630 640 650
SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL
660 670 680 690 700
VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS
710 720 730 740 750
RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG
760 770
SQYVPKSFQR TTLTFKRRFQ VTS
Length:773
Mass (Da):82,698
Last modified:February 26, 2008 - v2
Checksum:i287183E70F1901E5
GO
Isoform 2 (identifier: A5PLN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.

Show »
Length:482
Mass (Da):53,250
Checksum:i7B976B1F92E4661C
GO
Isoform 3 (identifier: A5PLN7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-723: Missing.

Show »
Length:772
Mass (Da):82,569
Checksum:iA82BA8F493E45281
GO
Isoform 4 (identifier: A5PLN7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-235: Missing.

Note: No experimental confirmation available.
Show »
Length:764
Mass (Da):81,787
Checksum:i1F673FAE56038E4F
GO

Sequence cautioni

The sequence AAI10817 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ13641 differs from that shown. Reason: Frameshift at position 635.Curated
The sequence AAQ13641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti431P → L in CAB45695 (PubMed:17974005).Curated1
Sequence conflicti635R → G in AAQ13641 (Ref. 3) Curated1
Sequence conflicti644D → N in AAI42993 (PubMed:15489334).Curated1
Sequence conflicti730S → G in CAB45695 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039050332K → E.1 PublicationCorresponds to variant rs4862650dbSNPEnsembl.1
Natural variantiVAR_039051437K → E.2 PublicationsCorresponds to variant rs4862653dbSNPEnsembl.1
Natural variantiVAR_039052505H → R.2 PublicationsCorresponds to variant rs2276924dbSNPEnsembl.1
Natural variantiVAR_039053532P → L.Corresponds to variant rs2276922dbSNPEnsembl.1
Natural variantiVAR_039054722R → W.Corresponds to variant rs9991339dbSNPEnsembl.1
Natural variantiVAR_039055748L → V.Corresponds to variant rs6818265dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0315301 – 291Missing in isoform 2. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_031531227 – 235Missing in isoform 4. Curated9
Alternative sequenceiVSP_031532723Missing in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSiCCDS34117.1. [A5PLN7-2]
PIRiT12464.
RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_016863486.1. XM_017007997.1. [A5PLN7-4]
XP_016863491.1. XM_017008002.1. [A5PLN7-2]
XP_016863492.1. XM_017008003.1. [A5PLN7-2]
XP_016863493.1. XM_017008004.1. [A5PLN7-2]
XP_016863494.1. XM_017008005.1. [A5PLN7-2]
UniGeneiHs.744961.

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneIDi25854.
KEGGihsa:25854.
UCSCiuc003iyt.5. human. [A5PLN7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSiCCDS34117.1. [A5PLN7-2]
PIRiT12464.
RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_016863486.1. XM_017007997.1. [A5PLN7-4]
XP_016863491.1. XM_017008002.1. [A5PLN7-2]
XP_016863492.1. XM_017008003.1. [A5PLN7-2]
XP_016863493.1. XM_017008004.1. [A5PLN7-2]
XP_016863494.1. XM_017008005.1. [A5PLN7-2]
UniGeneiHs.744961.

3D structure databases

ProteinModelPortaliA5PLN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000227065.

PTM databases

iPTMnetiA5PLN7.
PhosphoSitePlusiA5PLN7.

Polymorphism and mutation databases

BioMutaiFAM149A.

Proteomic databases

PaxDbiA5PLN7.
PRIDEiA5PLN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneIDi25854.
KEGGihsa:25854.
UCSCiuc003iyt.5. human. [A5PLN7-1]

Organism-specific databases

CTDi25854.
GeneCardsiFAM149A.
H-InvDBHIX0031434.
HGNCiHGNC:24527. FAM149A.
HPAiHPA055004.
neXtProtiNX_A5PLN7.
OpenTargetsiENSG00000109794.
PharmGKBiPA162386366.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE96. Eukaryota.
ENOG410ZYXN. LUCA.
GeneTreeiENSGT00530000063727.
HOGENOMiHOG000112437.
HOVERGENiHBG107111.
InParanoidiA5PLN7.
OMAiRSSIYSW.
OrthoDBiEOG091G05T8.
PhylomeDBiA5PLN7.
TreeFamiTF330725.

Miscellaneous databases

GenomeRNAii25854.
PROiA5PLN7.

Gene expression databases

BgeeiENSG00000109794.
CleanExiHS_FAM149A.
ExpressionAtlasiA5PLN7. baseline and differential.
GenevisibleiA5PLN7. HS.

Family and domain databases

InterProiIPR022194. DUF3719.
[Graphical view]
PfamiPF12516. DUF3719. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF149A_HUMAN
AccessioniPrimary (citable) accession number: A5PLN7
Secondary accession number(s): B5MDB8
, Q2TAN6, Q7Z2S5, Q9Y4T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.