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A5PLN7

- F149A_HUMAN

UniProt

A5PLN7 - F149A_HUMAN

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Protein
Protein FAM149A
Gene
FAM149A, MST119
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM149A
Gene namesi
Name:FAM149A
ORF Names:MST119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24527. FAM149A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386366.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773Protein FAM149A
PRO_0000319930Add
BLAST

Proteomic databases

PaxDbiA5PLN7.
PRIDEiA5PLN7.

PTM databases

PhosphoSiteiA5PLN7.

Expressioni

Gene expression databases

ArrayExpressiA5PLN7.
BgeeiA5PLN7.
CleanExiHS_FAM149A.
GenevestigatoriA5PLN7.

Organism-specific databases

HPAiHPA055004.

Structurei

3D structure databases

ProteinModelPortaliA5PLN7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 374Poly-Ala
Compositional biasi98 – 14952Pro-rich
Add
BLAST
Compositional biasi228 – 28154Ser-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM149 family.

Phylogenomic databases

eggNOGiNOG27759.
HOGENOMiHOG000112437.
HOVERGENiHBG107111.
InParanoidiA5PLN7.
OMAiQRPTYFA.
OrthoDBiEOG7R8319.
PhylomeDBiA5PLN7.
TreeFamiTF330725.

Family and domain databases

InterProiIPR022194. DUF3719.
[Graphical view]
PfamiPF12516. DUF3719. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A5PLN7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT    50
APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS 100
PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG 150
ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG 200
FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS 250
ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP 300
QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP 350
LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE 400
VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK 450
DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH 500
VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM 550
TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL 600
SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL 650
VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS 700
RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG 750
SQYVPKSFQR TTLTFKRRFQ VTS 773
Length:773
Mass (Da):82,698
Last modified:February 26, 2008 - v2
Checksum:i287183E70F1901E5
GO
Isoform 2 (identifier: A5PLN7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.

Show »
Length:482
Mass (Da):53,250
Checksum:i7B976B1F92E4661C
GO
Isoform 3 (identifier: A5PLN7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     723-723: Missing.

Show »
Length:772
Mass (Da):82,569
Checksum:iA82BA8F493E45281
GO
Isoform 4 (identifier: A5PLN7-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-235: Missing.

Note: No experimental confirmation available.

Show »
Length:764
Mass (Da):81,787
Checksum:i1F673FAE56038E4F
GO

Sequence cautioni

The sequence AAQ13641.1 differs from that shown. Reason: Frameshift at position 635.
The sequence AAI10817.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAQ13641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321K → E.1 Publication
Corresponds to variant rs4862650 [ dbSNP | Ensembl ].
VAR_039050
Natural varianti437 – 4371K → E.2 Publications
Corresponds to variant rs4862653 [ dbSNP | Ensembl ].
VAR_039051
Natural varianti505 – 5051H → R.2 Publications
Corresponds to variant rs2276924 [ dbSNP | Ensembl ].
VAR_039052
Natural varianti532 – 5321P → L.
Corresponds to variant rs2276922 [ dbSNP | Ensembl ].
VAR_039053
Natural varianti722 – 7221R → W.
Corresponds to variant rs9991339 [ dbSNP | Ensembl ].
VAR_039054
Natural varianti748 – 7481L → V.
Corresponds to variant rs6818265 [ dbSNP | Ensembl ].
VAR_039055

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 291291Missing in isoform 2.
VSP_031530Add
BLAST
Alternative sequencei227 – 2359Missing in isoform 4.
VSP_031531
Alternative sequencei723 – 7231Missing in isoform 3.
VSP_031532

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti431 – 4311P → L in CAB45695. 1 Publication
Sequence conflicti635 – 6351R → G in AAQ13641. 1 Publication
Sequence conflicti644 – 6441D → N in AAI42993. 1 Publication
Sequence conflicti730 – 7301S → G in CAB45695. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSiCCDS34117.1. [A5PLN7-2]
PIRiT12464.
RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_005262961.1. XM_005262904.2. [A5PLN7-1]
XP_005262962.1. XM_005262905.2. [A5PLN7-3]
XP_005262963.1. XM_005262906.2. [A5PLN7-4]
UniGeneiHs.744961.

Genome annotation databases

EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000389354; ENSP00000374005; ENSG00000109794. [A5PLN7-2]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneIDi25854.
KEGGihsa:25854.
UCSCiuc003iyt.4. human. [A5PLN7-1]
uc010isj.2. human. [A5PLN7-2]
uc011clb.2. human. [A5PLN7-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1 . Different initiation.
BC142992 mRNA. Translation: AAI42993.1 .
AF173894 mRNA. Translation: AAQ13641.1 . Sequence problems.
AL080065 mRNA. Translation: CAB45695.2 .
CCDSi CCDS34117.1. [A5PLN7-2 ]
PIRi T12464.
RefSeqi NP_001006656.1. NM_001006655.2. [A5PLN7-2 ]
NP_056213.1. NM_015398.2. [A5PLN7-2 ]
XP_005262961.1. XM_005262904.2. [A5PLN7-1 ]
XP_005262962.1. XM_005262905.2. [A5PLN7-3 ]
XP_005262963.1. XM_005262906.2. [A5PLN7-4 ]
UniGenei Hs.744961.

3D structure databases

ProteinModelPortali A5PLN7.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei A5PLN7.

Proteomic databases

PaxDbi A5PLN7.
PRIDEi A5PLN7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227065 ; ENSP00000227065 ; ENSG00000109794 . [A5PLN7-2 ]
ENST00000356371 ; ENSP00000348732 ; ENSG00000109794 . [A5PLN7-1 ]
ENST00000389354 ; ENSP00000374005 ; ENSG00000109794 . [A5PLN7-2 ]
ENST00000502970 ; ENSP00000427155 ; ENSG00000109794 . [A5PLN7-2 ]
ENST00000503432 ; ENSP00000426835 ; ENSG00000109794 . [A5PLN7-2 ]
ENST00000514153 ; ENSP00000424380 ; ENSG00000109794 . [A5PLN7-2 ]
GeneIDi 25854.
KEGGi hsa:25854.
UCSCi uc003iyt.4. human. [A5PLN7-1 ]
uc010isj.2. human. [A5PLN7-2 ]
uc011clb.2. human. [A5PLN7-3 ]

Organism-specific databases

CTDi 25854.
GeneCardsi GC04P187026.
H-InvDB HIX0031434.
HGNCi HGNC:24527. FAM149A.
HPAi HPA055004.
neXtProti NX_A5PLN7.
PharmGKBi PA162386366.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27759.
HOGENOMi HOG000112437.
HOVERGENi HBG107111.
InParanoidi A5PLN7.
OMAi QRPTYFA.
OrthoDBi EOG7R8319.
PhylomeDBi A5PLN7.
TreeFami TF330725.

Miscellaneous databases

GenomeRNAii 25854.
NextBioi 47208.
PROi A5PLN7.

Gene expression databases

ArrayExpressi A5PLN7.
Bgeei A5PLN7.
CleanExi HS_FAM149A.
Genevestigatori A5PLN7.

Family and domain databases

InterProi IPR022194. DUF3719.
[Graphical view ]
Pfami PF12516. DUF3719. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-332; GLU-437 AND ARG-505.
    Tissue: Brain.
  3. "Homo sapiens normal heart mRNA MST119."
    Qin B.M., Wang X.Y., Zhao B., Liu B., Liu Y.Q., Sheng H., Hui R.T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-773.
    Tissue: Heart.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-773, VARIANTS GLU-437 AND ARG-505.
    Tissue: Brain.

Entry informationi

Entry nameiF149A_HUMAN
AccessioniPrimary (citable) accession number: A5PLN7
Secondary accession number(s): B5MDB8
, Q2TAN6, Q7Z2S5, Q9Y4T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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