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A5PLN7 (F149A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM149A
Gene names
Name:FAM149A
ORF Names:MST119
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM149 family.

Sequence caution

The sequence AAI10817.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAQ13641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAQ13641.1 differs from that shown. Reason: Frameshift at position 635.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A5PLN7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A5PLN7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-291: Missing.
Isoform 3 (identifier: A5PLN7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     723-723: Missing.
Isoform 4 (identifier: A5PLN7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     227-235: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 773773Protein FAM149A
PRO_0000319930

Regions

Compositional bias34 – 374Poly-Ala
Compositional bias98 – 14952Pro-rich
Compositional bias228 – 28154Ser-rich

Natural variations

Alternative sequence1 – 291291Missing in isoform 2.
VSP_031530
Alternative sequence227 – 2359Missing in isoform 4.
VSP_031531
Alternative sequence7231Missing in isoform 3.
VSP_031532
Natural variant3321K → E. Ref.2
Corresponds to variant rs4862650 [ dbSNP | Ensembl ].
VAR_039050
Natural variant4371K → E. Ref.2 Ref.4
Corresponds to variant rs4862653 [ dbSNP | Ensembl ].
VAR_039051
Natural variant5051H → R. Ref.2 Ref.4
Corresponds to variant rs2276924 [ dbSNP | Ensembl ].
VAR_039052
Natural variant5321P → L.
Corresponds to variant rs2276922 [ dbSNP | Ensembl ].
VAR_039053
Natural variant7221R → W.
Corresponds to variant rs9991339 [ dbSNP | Ensembl ].
VAR_039054
Natural variant7481L → V.
Corresponds to variant rs6818265 [ dbSNP | Ensembl ].
VAR_039055

Experimental info

Sequence conflict4311P → L in CAB45695. Ref.4
Sequence conflict6351R → G in AAQ13641. Ref.3
Sequence conflict6441D → N in AAI42993. Ref.2
Sequence conflict7301S → G in CAB45695. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 287183E70F1901E5

FASTA77382,698
        10         20         30         40         50         60 
MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT APTLLRALAP 

        70         80         90        100        110        120 
DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS PRAGKAPPQP PTPSGGGCSP 

       130        140        150        160        170        180 
ARLVVPARPP SGPGGVWAAL PRNPLQPGPG ERELGACVAP GAGPRTLFLT LPDIGEEGAS 

       190        200        210        220        230        240 
DGDSGDGEAR GLSEGRRRHG FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP 

       250        260        270        280        290        300 
TGAHTSWSGS ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP 

       310        320        330        340        350        360 
QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP LSACGHSSNI 

       370        380        390        400        410        420 
RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE VYHVDGKIEE YFAFDRKEDD 

       430        440        450        460        470        480 
DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK DAVAAEVFDH VWTNMVELLE ELIRKHWETT 

       490        500        510        520        530        540 
LTEGKKQRET LKVAGNRFPH VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS 

       550        560        570        580        590        600 
SFYSDMNGVM TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL 

       610        620        630        640        650        660 
SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL VQTSRSRFPP 

       670        680        690        700        710        720 
LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS RLRERTATLE RLSRPSTTHT 

       730        740        750        760        770 
FRQSDTPRKS SLTQMEFAAH TWTGQSILTG SQYVPKSFQR TTLTFKRRFQ VTS 

« Hide

Isoform 2 [UniParc].

Checksum: 7B976B1F92E4661C
Show »

FASTA48253,250
Isoform 3 [UniParc].

Checksum: A82BA8F493E45281
Show »

FASTA77282,569
Isoform 4 [UniParc].

Checksum: 1F673FAE56038E4F
Show »

FASTA76481,787

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-332; GLU-437 AND ARG-505.
Tissue: Brain.
[3]"Homo sapiens normal heart mRNA MST119."
Qin B.M., Wang X.Y., Zhao B., Liu B., Liu Y.Q., Sheng H., Hui R.T.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-773.
Tissue: Heart.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-773, VARIANTS GLU-437 AND ARG-505.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC104070 Genomic DNA. No translation available.
AC110771 Genomic DNA. No translation available.
BC110816 mRNA. Translation: AAI10817.1. Different initiation.
BC142992 mRNA. Translation: AAI42993.1.
AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
AL080065 mRNA. Translation: CAB45695.2.
CCDSCCDS34117.1. [A5PLN7-2]
PIRT12464.
RefSeqNP_001006656.1. NM_001006655.2. [A5PLN7-2]
NP_056213.1. NM_015398.2. [A5PLN7-2]
XP_005262961.1. XM_005262904.2. [A5PLN7-1]
XP_005262962.1. XM_005262905.2. [A5PLN7-3]
XP_005262963.1. XM_005262906.2. [A5PLN7-4]
UniGeneHs.744961.

3D structure databases

ProteinModelPortalA5PLN7.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA5PLN7.

Proteomic databases

PaxDbA5PLN7.
PRIDEA5PLN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
ENST00000389354; ENSP00000374005; ENSG00000109794. [A5PLN7-2]
ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
GeneID25854.
KEGGhsa:25854.
UCSCuc003iyt.4. human. [A5PLN7-1]
uc010isj.2. human. [A5PLN7-2]
uc011clb.2. human. [A5PLN7-3]

Organism-specific databases

CTD25854.
GeneCardsGC04P187026.
H-InvDBHIX0031434.
HGNCHGNC:24527. FAM149A.
HPAHPA055004.
neXtProtNX_A5PLN7.
PharmGKBPA162386366.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27759.
HOGENOMHOG000112437.
HOVERGENHBG107111.
InParanoidA5PLN7.
OMAQRPTYFA.
OrthoDBEOG7R8319.
PhylomeDBA5PLN7.
TreeFamTF330725.

Gene expression databases

ArrayExpressA5PLN7.
BgeeA5PLN7.
CleanExHS_FAM149A.
GenevestigatorA5PLN7.

Family and domain databases

InterProIPR022194. DUF3719.
[Graphical view]
PfamPF12516. DUF3719. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25854.
NextBio47208.
PROA5PLN7.

Entry information

Entry nameF149A_HUMAN
AccessionPrimary (citable) accession number: A5PLN7
Secondary accession number(s): B5MDB8 expand/collapse secondary AC list , Q2TAN6, Q7Z2S5, Q9Y4T9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM