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A5PLN7

- F149A_HUMAN

UniProt

A5PLN7 - F149A_HUMAN

Protein

Protein FAM149A

Gene

FAM149A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM149A
    Gene namesi
    Name:FAM149A
    ORF Names:MST119
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24527. FAM149A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386366.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773Protein FAM149APRO_0000319930Add
    BLAST

    Proteomic databases

    PaxDbiA5PLN7.
    PRIDEiA5PLN7.

    PTM databases

    PhosphoSiteiA5PLN7.

    Expressioni

    Gene expression databases

    ArrayExpressiA5PLN7.
    BgeeiA5PLN7.
    CleanExiHS_FAM149A.
    GenevestigatoriA5PLN7.

    Organism-specific databases

    HPAiHPA055004.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PLN7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 374Poly-Ala
    Compositional biasi98 – 14952Pro-richAdd
    BLAST
    Compositional biasi228 – 28154Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM149 family.Curated

    Phylogenomic databases

    eggNOGiNOG27759.
    HOGENOMiHOG000112437.
    HOVERGENiHBG107111.
    InParanoidiA5PLN7.
    OMAiQRPTYFA.
    OrthoDBiEOG7R8319.
    PhylomeDBiA5PLN7.
    TreeFamiTF330725.

    Family and domain databases

    InterProiIPR022194. DUF3719.
    [Graphical view]
    PfamiPF12516. DUF3719. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A5PLN7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKAAVLDLGS LLAKLFETST APPAGPSSRP SGGAAAAGSG GSRAGTPLGT    50
    APTLLRALAP DSPSASRRSP APLLSSPYSR GSAASRAAGA VGTLLSWPSS 100
    PRAGKAPPQP PTPSGGGCSP ARLVVPARPP SGPGGVWAAL PRNPLQPGPG 150
    ERELGACVAP GAGPRTLFLT LPDIGEEGAS DGDSGDGEAR GLSEGRRRHG 200
    FTVRSKDSLP THFTRNVQKA IDKYTCKSLS SFSSSGSHTP TGAHTSWSGS 250
    ATQSSTTGSS TERGSVYSWR DDEFDEASSQ SVQRLLWEVE EMLFEGKVNP 300
    QTQSLLAECG EWTRRSLHLR VLGRQLILPT DKGVQHFQGS TPASAVHRPP 350
    LSACGHSSNI RELCISGSQI VPAALSASAL PGPDDTGVAD LTARSSLEEE 400
    VYHVDGKIEE YFAFDRKEDD DECLEQKPAQ PGRKWRKLGL PPVSPRDCVK 450
    DAVAAEVFDH VWTNMVELLE ELIRKHWETT LTEGKKQRET LKVAGNRFPH 500
    VLVPHAHADG ASGPPSGHAE AHGISLASRL NPPQIHHFSS SFYSDMNGVM 550
    TIQAKPLQRR PAYFADRTQN EKEDKASGGG AGALSSAPHR LGRASDTHGL 600
    SPSAKKTPVP WRLPSLASDS QRLKTPNIYS DEVLRGTKLP TGVDHMASPL 650
    VQTSRSRFPP LVTETRGQNT AVPGCRLVSY RGRHLQNRVL SAMPDGTERS 700
    RLRERTATLE RLSRPSTTHT FRQSDTPRKS SLTQMEFAAH TWTGQSILTG 750
    SQYVPKSFQR TTLTFKRRFQ VTS 773
    Length:773
    Mass (Da):82,698
    Last modified:February 26, 2008 - v2
    Checksum:i287183E70F1901E5
    GO
    Isoform 2 (identifier: A5PLN7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-291: Missing.

    Show »
    Length:482
    Mass (Da):53,250
    Checksum:i7B976B1F92E4661C
    GO
    Isoform 3 (identifier: A5PLN7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         723-723: Missing.

    Show »
    Length:772
    Mass (Da):82,569
    Checksum:iA82BA8F493E45281
    GO
    Isoform 4 (identifier: A5PLN7-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-235: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:764
    Mass (Da):81,787
    Checksum:i1F673FAE56038E4F
    GO

    Sequence cautioni

    The sequence AAQ13641.1 differs from that shown. Reason: Frameshift at position 635.
    The sequence AAI10817.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAQ13641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti431 – 4311P → L in CAB45695. (PubMed:17974005)Curated
    Sequence conflicti635 – 6351R → G in AAQ13641. 1 PublicationCurated
    Sequence conflicti644 – 6441D → N in AAI42993. (PubMed:15489334)Curated
    Sequence conflicti730 – 7301S → G in CAB45695. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti332 – 3321K → E.1 Publication
    Corresponds to variant rs4862650 [ dbSNP | Ensembl ].
    VAR_039050
    Natural varianti437 – 4371K → E.2 Publications
    Corresponds to variant rs4862653 [ dbSNP | Ensembl ].
    VAR_039051
    Natural varianti505 – 5051H → R.2 Publications
    Corresponds to variant rs2276924 [ dbSNP | Ensembl ].
    VAR_039052
    Natural varianti532 – 5321P → L.
    Corresponds to variant rs2276922 [ dbSNP | Ensembl ].
    VAR_039053
    Natural varianti722 – 7221R → W.
    Corresponds to variant rs9991339 [ dbSNP | Ensembl ].
    VAR_039054
    Natural varianti748 – 7481L → V.
    Corresponds to variant rs6818265 [ dbSNP | Ensembl ].
    VAR_039055

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 291291Missing in isoform 2. 1 PublicationVSP_031530Add
    BLAST
    Alternative sequencei227 – 2359Missing in isoform 4. CuratedVSP_031531
    Alternative sequencei723 – 7231Missing in isoform 3. CuratedVSP_031532

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104070 Genomic DNA. No translation available.
    AC110771 Genomic DNA. No translation available.
    BC110816 mRNA. Translation: AAI10817.1. Different initiation.
    BC142992 mRNA. Translation: AAI42993.1.
    AF173894 mRNA. Translation: AAQ13641.1. Sequence problems.
    AL080065 mRNA. Translation: CAB45695.2.
    CCDSiCCDS34117.1. [A5PLN7-2]
    PIRiT12464.
    RefSeqiNP_001006656.1. NM_001006655.2. [A5PLN7-2]
    NP_056213.1. NM_015398.2. [A5PLN7-2]
    XP_005262961.1. XM_005262904.2. [A5PLN7-1]
    XP_005262962.1. XM_005262905.2. [A5PLN7-3]
    XP_005262963.1. XM_005262906.2. [A5PLN7-4]
    UniGeneiHs.744961.

    Genome annotation databases

    EnsembliENST00000227065; ENSP00000227065; ENSG00000109794. [A5PLN7-2]
    ENST00000356371; ENSP00000348732; ENSG00000109794. [A5PLN7-1]
    ENST00000389354; ENSP00000374005; ENSG00000109794. [A5PLN7-2]
    ENST00000502970; ENSP00000427155; ENSG00000109794. [A5PLN7-2]
    ENST00000503432; ENSP00000426835; ENSG00000109794. [A5PLN7-2]
    ENST00000514153; ENSP00000424380; ENSG00000109794. [A5PLN7-2]
    GeneIDi25854.
    KEGGihsa:25854.
    UCSCiuc003iyt.4. human. [A5PLN7-1]
    uc010isj.2. human. [A5PLN7-2]
    uc011clb.2. human. [A5PLN7-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104070 Genomic DNA. No translation available.
    AC110771 Genomic DNA. No translation available.
    BC110816 mRNA. Translation: AAI10817.1 . Different initiation.
    BC142992 mRNA. Translation: AAI42993.1 .
    AF173894 mRNA. Translation: AAQ13641.1 . Sequence problems.
    AL080065 mRNA. Translation: CAB45695.2 .
    CCDSi CCDS34117.1. [A5PLN7-2 ]
    PIRi T12464.
    RefSeqi NP_001006656.1. NM_001006655.2. [A5PLN7-2 ]
    NP_056213.1. NM_015398.2. [A5PLN7-2 ]
    XP_005262961.1. XM_005262904.2. [A5PLN7-1 ]
    XP_005262962.1. XM_005262905.2. [A5PLN7-3 ]
    XP_005262963.1. XM_005262906.2. [A5PLN7-4 ]
    UniGenei Hs.744961.

    3D structure databases

    ProteinModelPortali A5PLN7.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A5PLN7.

    Proteomic databases

    PaxDbi A5PLN7.
    PRIDEi A5PLN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227065 ; ENSP00000227065 ; ENSG00000109794 . [A5PLN7-2 ]
    ENST00000356371 ; ENSP00000348732 ; ENSG00000109794 . [A5PLN7-1 ]
    ENST00000389354 ; ENSP00000374005 ; ENSG00000109794 . [A5PLN7-2 ]
    ENST00000502970 ; ENSP00000427155 ; ENSG00000109794 . [A5PLN7-2 ]
    ENST00000503432 ; ENSP00000426835 ; ENSG00000109794 . [A5PLN7-2 ]
    ENST00000514153 ; ENSP00000424380 ; ENSG00000109794 . [A5PLN7-2 ]
    GeneIDi 25854.
    KEGGi hsa:25854.
    UCSCi uc003iyt.4. human. [A5PLN7-1 ]
    uc010isj.2. human. [A5PLN7-2 ]
    uc011clb.2. human. [A5PLN7-3 ]

    Organism-specific databases

    CTDi 25854.
    GeneCardsi GC04P187026.
    H-InvDB HIX0031434.
    HGNCi HGNC:24527. FAM149A.
    HPAi HPA055004.
    neXtProti NX_A5PLN7.
    PharmGKBi PA162386366.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27759.
    HOGENOMi HOG000112437.
    HOVERGENi HBG107111.
    InParanoidi A5PLN7.
    OMAi QRPTYFA.
    OrthoDBi EOG7R8319.
    PhylomeDBi A5PLN7.
    TreeFami TF330725.

    Miscellaneous databases

    GenomeRNAii 25854.
    NextBioi 47208.
    PROi A5PLN7.

    Gene expression databases

    ArrayExpressi A5PLN7.
    Bgeei A5PLN7.
    CleanExi HS_FAM149A.
    Genevestigatori A5PLN7.

    Family and domain databases

    InterProi IPR022194. DUF3719.
    [Graphical view ]
    Pfami PF12516. DUF3719. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS GLU-332; GLU-437 AND ARG-505.
      Tissue: Brain.
    3. "Homo sapiens normal heart mRNA MST119."
      Qin B.M., Wang X.Y., Zhao B., Liu B., Liu Y.Q., Sheng H., Hui R.T.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 212-773.
      Tissue: Heart.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 417-773, VARIANTS GLU-437 AND ARG-505.
      Tissue: Brain.

    Entry informationi

    Entry nameiF149A_HUMAN
    AccessioniPrimary (citable) accession number: A5PLN7
    Secondary accession number(s): B5MDB8
    , Q2TAN6, Q7Z2S5, Q9Y4T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3