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Protein

Transmembrane protein 189

Gene

TMEM189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 189
Gene namesi
Name:TMEM189Imported
Synonyms:KUA1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16735. TMEM189.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406226.

Polymorphism and mutation databases

BioMutaiTMEM189.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Transmembrane protein 189PRO_0000319993Add
BLAST

Proteomic databases

EPDiA5PLL7.
MaxQBiA5PLL7.
PRIDEiA5PLL7.

PTM databases

iPTMnetiA5PLL7.
PhosphoSiteiA5PLL7.
SwissPalmiA5PLL7.

Expressioni

Gene expression databases

BgeeiENSG00000240849.
ExpressionAtlasiA5PLL7. baseline and differential.
GenevisibleiA5PLL7. HS.

Organism-specific databases

HPAiHPA059549.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi132320. 21 interactions.
132321. 14 interactions.
IntActiA5PLL7. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA5PLL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000115607.
HOGENOMiHOG000257103.
HOVERGENiHBG058716.
InParanoidiA5PLL7.
KOiK10704.
OMAiALTNQIH.
OrthoDBiEOG091G0SMT.
PhylomeDBiA5PLL7.

Family and domain databases

InterProiIPR019547. TMEM189_B_dmain.
[Graphical view]
PfamiPF10520. TMEM189_B_dmain. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5PLL7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAENWPGQ QLELDEDEAS CCRWGAQHAG ARELAALYSP GKRLQEWCSV
60 70 80 90 100
ILCFSLIAHN LVHLLLLARW EDTPLVILGV VAGALIADFL SGLVHWGADT
110 120 130 140 150
WGSVELPIVG KAFIRPFREH HIDPTAITRH DFIETNGDNC LVTLLPLLNM
160 170 180 190 200
AYKFRTHSPE ALEQLYPWEC FVFCLIIFGT FTNQIHKWSH TYFGLPRWVT
210 220 230 240 250
LLQDWHVILP RKHHRIHHVS PHETYFCITT GWLNYPLEKI GFWRRLEDLI
260 270
QGLTGEKPRA DDMKWAQKIK
Length:270
Mass (Da):31,135
Last modified:November 2, 2010 - v3
Checksum:i960E639B6F1B55ED
GO
Isoform 2 (identifier: A5PLL7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-111: Missing.

Show »
Length:267
Mass (Da):30,851
Checksum:i7470903C736C4016
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61N → D in AAF08702 (PubMed:11076860).Curated
Sequence conflicti6 – 61N → D in BAB18652 (PubMed:11280764).Curated
Sequence conflicti6 – 61N → D in BAB14364 (PubMed:11780052).Curated
Sequence conflicti6 – 61N → D in AAI42967 (PubMed:15489334).Curated
Sequence conflicti121 – 1211H → N in AAI42967 (PubMed:15489334).Curated
Sequence conflicti167 – 1671P → H in AAI42967 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71W → G.
Corresponds to variant rs2026757 [ dbSNP | Ensembl ].
VAR_059732

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei109 – 1113Missing in isoform 2. 1 PublicationVSP_054091

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155120 mRNA. Translation: AAF08702.1.
AB044550 mRNA. Translation: BAB18652.1.
AK023028 mRNA. Translation: BAB14364.1.
AL034423 Genomic DNA. No translation available.
BC142966 mRNA. Translation: AAI42967.1.
CCDSiCCDS13428.1. [A5PLL7-1]
CCDS54473.1. [A5PLL7-2]
RefSeqiNP_001155977.1. NM_001162505.1.
NP_954580.1. NM_199129.2.
NP_954673.1. NM_199203.2.
UniGeneiHs.744839.

Genome annotation databases

EnsembliENST00000371650; ENSP00000360713; ENSG00000240849. [A5PLL7-2]
ENST00000371652; ENSP00000360715; ENSG00000240849. [A5PLL7-1]
GeneIDi387521.
387522.
KEGGihsa:387521.
hsa:387522.
UCSCiuc002xvg.3. human. [A5PLL7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155120 mRNA. Translation: AAF08702.1.
AB044550 mRNA. Translation: BAB18652.1.
AK023028 mRNA. Translation: BAB14364.1.
AL034423 Genomic DNA. No translation available.
BC142966 mRNA. Translation: AAI42967.1.
CCDSiCCDS13428.1. [A5PLL7-1]
CCDS54473.1. [A5PLL7-2]
RefSeqiNP_001155977.1. NM_001162505.1.
NP_954580.1. NM_199129.2.
NP_954673.1. NM_199203.2.
UniGeneiHs.744839.

3D structure databases

ProteinModelPortaliA5PLL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132320. 21 interactions.
132321. 14 interactions.
IntActiA5PLL7. 1 interaction.

PTM databases

iPTMnetiA5PLL7.
PhosphoSiteiA5PLL7.
SwissPalmiA5PLL7.

Polymorphism and mutation databases

BioMutaiTMEM189.

Proteomic databases

EPDiA5PLL7.
MaxQBiA5PLL7.
PRIDEiA5PLL7.

Protocols and materials databases

DNASUi387522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371650; ENSP00000360713; ENSG00000240849. [A5PLL7-2]
ENST00000371652; ENSP00000360715; ENSG00000240849. [A5PLL7-1]
GeneIDi387521.
387522.
KEGGihsa:387521.
hsa:387522.
UCSCiuc002xvg.3. human. [A5PLL7-1]

Organism-specific databases

CTDi387521.
387522.
GeneCardsiTMEM189.
HGNCiHGNC:16735. TMEM189.
HPAiHPA059549.
MIMi610994. gene.
neXtProtiNX_A5PLL7.
PharmGKBiPA162406226.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00740000115607.
HOGENOMiHOG000257103.
HOVERGENiHBG058716.
InParanoidiA5PLL7.
KOiK10704.
OMAiALTNQIH.
OrthoDBiEOG091G0SMT.
PhylomeDBiA5PLL7.

Miscellaneous databases

GeneWikiiKua-UEV.
PROiA5PLL7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000240849.
ExpressionAtlasiA5PLL7. baseline and differential.
GenevisibleiA5PLL7. HS.

Family and domain databases

InterProiIPR019547. TMEM189_B_dmain.
[Graphical view]
PfamiPF10520. TMEM189_B_dmain. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM189_HUMAN
AccessioniPrimary (citable) accession number: A5PLL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.