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A5PLL1

- AN34B_HUMAN

UniProt

A5PLL1 - AN34B_HUMAN

Protein

Ankyrin repeat domain-containing protein 34B

Gene

ANKRD34B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 34B
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:33736. ANKRD34B.

    Subcellular locationi

    Cytoplasm. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376576.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Ankyrin repeat domain-containing protein 34BPRO_0000319102Add
    BLAST

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA5PLL1.
    PRIDEiA5PLL1.

    PTM databases

    PhosphoSiteiA5PLL1.

    Expressioni

    Gene expression databases

    BgeeiA5PLL1.
    CleanExiHS_ANKRD34B.
    GenevestigatoriA5PLL1.

    Organism-specific databases

    HPAiHPA043327.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000339802.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PLL1.
    SMRiA5PLL1. Positions 8-139.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati9 – 3830ANK 1Add
    BLAST
    Repeati42 – 7938ANK 2Add
    BLAST
    Repeati83 – 11331ANK 3Add
    BLAST
    Repeati117 – 14630ANK 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the ANKRD34 family.Curated
    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG68360.
    HOGENOMiHOG000033934.
    HOVERGENiHBG100441.
    InParanoidiA5PLL1.
    OMAiIKAVHQS.
    OrthoDBiEOG7V49Z4.
    PhylomeDBiA5PLL1.
    TreeFamiTF331155.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5PLL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA    50
    CKTKHVDHQS VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV 100
    VSLLLKSGAD LSLQDHSSYS ALVYAINSED TETLKVLLSA CKAKGKEVII 150
    ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP ATCTTPSEID IKTASSPLSH 200
    SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP KLPHAPPWVK 250
    SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK 300
    DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI 350
    FASTLRSIVQ KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS 400
    PSQLSESKEL LENIPPGPLS RRNHAVLERR GSGAFPLDHS VTQTRQGFLP 450
    PLNVNSHPPI SDINVNNKIC SLLSCGQKVL MPTVPIFPKE FKSKKMLLRR 500
    QSLQTEQIKQ LVNF 514
    Length:514
    Mass (Da):56,414
    Last modified:October 5, 2010 - v3
    Checksum:i65B1CC8F92E0730E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti429 – 4291R → G in CAH18341. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti156 – 1561L → S.1 Publication
    Corresponds to variant rs32857 [ dbSNP | Ensembl ].
    VAR_038952

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR749535 mRNA. Translation: CAH18341.1.
    AC008434 Genomic DNA. No translation available.
    BC137441 mRNA. Translation: AAI37442.1.
    BC137442 mRNA. Translation: AAI37443.1.
    BC142957 mRNA. Translation: AAI42958.1.
    CCDSiCCDS34194.1.
    RefSeqiNP_001004441.2. NM_001004441.2.
    XP_006714662.1. XM_006714599.1.
    UniGeneiHs.519404.

    Genome annotation databases

    EnsembliENST00000338682; ENSP00000339802; ENSG00000189127.
    GeneIDi340120.
    KEGGihsa:340120.
    UCSCiuc003kgw.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR749535 mRNA. Translation: CAH18341.1 .
    AC008434 Genomic DNA. No translation available.
    BC137441 mRNA. Translation: AAI37442.1 .
    BC137442 mRNA. Translation: AAI37443.1 .
    BC142957 mRNA. Translation: AAI42958.1 .
    CCDSi CCDS34194.1.
    RefSeqi NP_001004441.2. NM_001004441.2.
    XP_006714662.1. XM_006714599.1.
    UniGenei Hs.519404.

    3D structure databases

    ProteinModelPortali A5PLL1.
    SMRi A5PLL1. Positions 8-139.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000339802.

    PTM databases

    PhosphoSitei A5PLL1.

    Proteomic databases

    PaxDbi A5PLL1.
    PRIDEi A5PLL1.

    Protocols and materials databases

    DNASUi 340120.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338682 ; ENSP00000339802 ; ENSG00000189127 .
    GeneIDi 340120.
    KEGGi hsa:340120.
    UCSCi uc003kgw.3. human.

    Organism-specific databases

    CTDi 340120.
    GeneCardsi GC05M079888.
    H-InvDB HIX0200791.
    HGNCi HGNC:33736. ANKRD34B.
    HPAi HPA043327.
    neXtProti NX_A5PLL1.
    PharmGKBi PA162376576.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68360.
    HOGENOMi HOG000033934.
    HOVERGENi HBG100441.
    InParanoidi A5PLL1.
    OMAi IKAVHQS.
    OrthoDBi EOG7V49Z4.
    PhylomeDBi A5PLL1.
    TreeFami TF331155.

    Miscellaneous databases

    ChiTaRSi ANKRD34B. human.
    GenomeRNAii 340120.
    NextBioi 97704.
    PROi A5PLL1.

    Gene expression databases

    Bgeei A5PLL1.
    CleanExi HS_ANKRD34B.
    Genevestigatori A5PLL1.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-156.
      Tissue: Rectum tumor.
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAN34B_HUMAN
    AccessioniPrimary (citable) accession number: A5PLL1
    Secondary accession number(s): B2RPH1, Q68D79
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 59 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3