A5PLL1 (AN34B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 34B

Gene names

Name:

ANKRD34B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	514 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm. Nucleus By similarity.
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Belongs to the ANKRD34 family. Contains 4 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 514	514	Ankyrin repeat domain-containing protein 34B		PRO_0000319102
Regions
	Repeat	9 – 38	30	ANK 1
	Repeat	42 – 79	38	ANK 2
	Repeat	83 – 113	31	ANK 3
	Repeat	117 – 146	30	ANK 4
Natural variations
	Natural variant	156	1	L → S. Ref.1 Corresponds to variant rs32857 [ dbSNP | Ensembl ].		VAR_038952
Experimental info
	Sequence conflict	429	1	R → G in CAH18341. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	A5PLL1 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 65B1CC8F92E0730E	FASTA	514	56,414
	10 20 30 40 50 60 MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS 70 80 90 100 110 120 VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS 130 140 150 160 170 180 ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP 190 200 210 220 230 240 ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP 250 260 270 280 290 300 KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK 310 320 330 340 350 360 DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ 370 380 390 400 410 420 KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS 430 440 450 460 470 480 RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL 490 500 510 MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-156. Tissue: Rectum tumor.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR749535 mRNA. Translation: CAH18341.1. AC008434 Genomic DNA. No translation available. BC137441 mRNA. Translation: AAI37442.1. BC137442 mRNA. Translation: AAI37443.1. BC142957 mRNA. Translation: AAI42958.1.
IPI	IPI00464959.
RefSeq	NP_001004441.2. NM_001004441.2.
UniGene	Hs.519404.
3D structure databases
ProteinModelPortal	A5PLL1.
SMR	A5PLL1. Positions 8-139.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000339802.
PTM databases
PhosphoSite	A5PLL1.
Proteomic databases
PaxDb	A5PLL1.
PRIDE	A5PLL1.
Protocols and materials databases
DNASU	340120.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338682; ENSP00000339802; ENSG00000189127.
GeneID	340120.
KEGG	hsa:340120.
UCSC	uc003kgw.3. human.
Organism-specific databases
CTD	340120.
GeneCards	GC05M079888.
H-InvDB	HIX0200791.
HGNC	HGNC:33736. ANKRD34B.
HPA	HPA043327.
neXtProt	NX_A5PLL1.
PharmGKB	PA162376576.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG68360.
HOGENOM	HOG000033934.
HOVERGEN	HBG100441.
InParanoid	A5PLL1.
OMA	SKRFITR.
OrthoDB	EOG4VQ9P2.
PhylomeDB	A5PLL1.
Gene expression databases
Bgee	A5PLL1.
CleanEx	HS_ANKRD34B.
Genevestigator	A5PLL1.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Pfam	PF12796. Ank_2. 1 hit. [Graphical view]
SMART	SM00248. ANK. 4 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANKRD34B. human.
GenomeRNAi	340120.
NextBio	97704.

Entry information

Entry name

AN34B_HUMAN

Accession

Primary (citable) accession number: A5PLL1
Secondary accession number(s): B2RPH1, Q68D79

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 5, 2010
Last modified:	May 1, 2013
This is version 49 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.