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A5PLL1 (AN34B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 34B
Gene names
Name:ANKRD34B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm. Nucleus By similarity.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Belongs to the ANKRD34 family.

Contains 4 ANK repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Ankyrin repeat domain-containing protein 34B
PRO_0000319102

Regions

Repeat9 – 3830ANK 1
Repeat42 – 7938ANK 2
Repeat83 – 11331ANK 3
Repeat117 – 14630ANK 4

Natural variations

Natural variant1561L → S. Ref.1
Corresponds to variant rs32857 [ dbSNP | Ensembl ].
VAR_038952

Experimental info

Sequence conflict4291R → G in CAH18341. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A5PLL1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 65B1CC8F92E0730E

FASTA51456,414
        10         20         30         40         50         60 
MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS 

        70         80         90        100        110        120 
VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS 

       130        140        150        160        170        180 
ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP 

       190        200        210        220        230        240 
ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP 

       250        260        270        280        290        300 
KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK 

       310        320        330        340        350        360 
DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ 

       370        380        390        400        410        420 
KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS 

       430        440        450        460        470        480 
RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL 

       490        500        510 
MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF 

« Hide

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-156.
Tissue: Rectum tumor.
[2]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR749535 mRNA. Translation: CAH18341.1.
AC008434 Genomic DNA. No translation available.
BC137441 mRNA. Translation: AAI37442.1.
BC137442 mRNA. Translation: AAI37443.1.
BC142957 mRNA. Translation: AAI42958.1.
CCDSCCDS34194.1.
RefSeqNP_001004441.2. NM_001004441.2.
XP_006714662.1. XM_006714599.1.
UniGeneHs.519404.

3D structure databases

ProteinModelPortalA5PLL1.
SMRA5PLL1. Positions 8-139.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000339802.

PTM databases

PhosphoSiteA5PLL1.

Proteomic databases

PaxDbA5PLL1.
PRIDEA5PLL1.

Protocols and materials databases

DNASU340120.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338682; ENSP00000339802; ENSG00000189127.
GeneID340120.
KEGGhsa:340120.
UCSCuc003kgw.3. human.

Organism-specific databases

CTD340120.
GeneCardsGC05M079888.
H-InvDBHIX0200791.
HGNCHGNC:33736. ANKRD34B.
HPAHPA043327.
neXtProtNX_A5PLL1.
PharmGKBPA162376576.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68360.
HOGENOMHOG000033934.
HOVERGENHBG100441.
InParanoidA5PLL1.
OMAIKAVHQS.
OrthoDBEOG7V49Z4.
PhylomeDBA5PLL1.
TreeFamTF331155.

Gene expression databases

BgeeA5PLL1.
CleanExHS_ANKRD34B.
GenevestigatorA5PLL1.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSANKRD34B. human.
GenomeRNAi340120.
NextBio97704.
PROA5PLL1.

Entry information

Entry nameAN34B_HUMAN
AccessionPrimary (citable) accession number: A5PLL1
Secondary accession number(s): B2RPH1, Q68D79
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 58 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM