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Protein

Ankyrin repeat domain-containing protein 34B

Gene

ANKRD34B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 34B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:33736. ANKRD34B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376576.

Polymorphism and mutation databases

BioMutaiANKRD34B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Ankyrin repeat domain-containing protein 34BPRO_0000319102Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA5PLL1.
PRIDEiA5PLL1.

PTM databases

PhosphoSiteiA5PLL1.

Expressioni

Gene expression databases

BgeeiA5PLL1.
CleanExiHS_ANKRD34B.
ExpressionAtlasiA5PLL1. baseline.

Organism-specific databases

HPAiHPA043327.

Structurei

3D structure databases

ProteinModelPortaliA5PLL1.
SMRiA5PLL1. Positions 8-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati9 – 3830ANK 1Add
BLAST
Repeati42 – 7938ANK 2Add
BLAST
Repeati83 – 11331ANK 3Add
BLAST
Repeati117 – 14630ANK 4Add
BLAST

Sequence similaritiesi

Belongs to the ANKRD34 family.Curated
Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG68360.
GeneTreeiENSGT00390000012355.
HOGENOMiHOG000033934.
HOVERGENiHBG100441.
InParanoidiA5PLL1.
OMAiIKAVHQS.
OrthoDBiEOG7V49Z4.
PhylomeDBiA5PLL1.
TreeFamiTF331155.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PLL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA
60 70 80 90 100
CKTKHVDHQS VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV
110 120 130 140 150
VSLLLKSGAD LSLQDHSSYS ALVYAINSED TETLKVLLSA CKAKGKEVII
160 170 180 190 200
ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP ATCTTPSEID IKTASSPLSH
210 220 230 240 250
SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP KLPHAPPWVK
260 270 280 290 300
SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK
310 320 330 340 350
DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI
360 370 380 390 400
FASTLRSIVQ KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS
410 420 430 440 450
PSQLSESKEL LENIPPGPLS RRNHAVLERR GSGAFPLDHS VTQTRQGFLP
460 470 480 490 500
PLNVNSHPPI SDINVNNKIC SLLSCGQKVL MPTVPIFPKE FKSKKMLLRR
510
QSLQTEQIKQ LVNF
Length:514
Mass (Da):56,414
Last modified:October 5, 2010 - v3
Checksum:i65B1CC8F92E0730E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291R → G in CAH18341 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561L → S.1 Publication
Corresponds to variant rs32857 [ dbSNP | Ensembl ].
VAR_038952

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749535 mRNA. Translation: CAH18341.1.
AC008434 Genomic DNA. No translation available.
BC137441 mRNA. Translation: AAI37442.1.
BC137442 mRNA. Translation: AAI37443.1.
BC142957 mRNA. Translation: AAI42958.1.
CCDSiCCDS34194.1.
RefSeqiNP_001004441.2. NM_001004441.2.
XP_006714662.1. XM_006714599.2.
UniGeneiHs.519404.

Genome annotation databases

EnsembliENST00000338682; ENSP00000339802; ENSG00000189127.
GeneIDi340120.
KEGGihsa:340120.
UCSCiuc003kgw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749535 mRNA. Translation: CAH18341.1.
AC008434 Genomic DNA. No translation available.
BC137441 mRNA. Translation: AAI37442.1.
BC137442 mRNA. Translation: AAI37443.1.
BC142957 mRNA. Translation: AAI42958.1.
CCDSiCCDS34194.1.
RefSeqiNP_001004441.2. NM_001004441.2.
XP_006714662.1. XM_006714599.2.
UniGeneiHs.519404.

3D structure databases

ProteinModelPortaliA5PLL1.
SMRiA5PLL1. Positions 8-169.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiA5PLL1.

Polymorphism and mutation databases

BioMutaiANKRD34B.

Proteomic databases

PaxDbiA5PLL1.
PRIDEiA5PLL1.

Protocols and materials databases

DNASUi340120.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338682; ENSP00000339802; ENSG00000189127.
GeneIDi340120.
KEGGihsa:340120.
UCSCiuc003kgw.3. human.

Organism-specific databases

CTDi340120.
GeneCardsiGC05M079888.
H-InvDBHIX0200791.
HGNCiHGNC:33736. ANKRD34B.
HPAiHPA043327.
neXtProtiNX_A5PLL1.
PharmGKBiPA162376576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68360.
GeneTreeiENSGT00390000012355.
HOGENOMiHOG000033934.
HOVERGENiHBG100441.
InParanoidiA5PLL1.
OMAiIKAVHQS.
OrthoDBiEOG7V49Z4.
PhylomeDBiA5PLL1.
TreeFamiTF331155.

Miscellaneous databases

ChiTaRSiANKRD34B. human.
GenomeRNAii340120.
NextBioi97704.
PROiA5PLL1.

Gene expression databases

BgeeiA5PLL1.
CleanExiHS_ANKRD34B.
ExpressionAtlasiA5PLL1. baseline.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-156.
    Tissue: Rectum tumor.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAN34B_HUMAN
AccessioniPrimary (citable) accession number: A5PLL1
Secondary accession number(s): B2RPH1, Q68D79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.