ID A5PLI3_DANRE Unreviewed; 372 AA. AC A5PLI3; DT 10-JUL-2007, integrated into UniProtKB/TrEMBL. DT 10-JUL-2007, sequence version 1. DT 27-MAR-2024, entry version 95. DE SubName: Full=C-C chemokine receptor type 7 precursor {ECO:0000313|RefSeq:NP_001092213.1}; DE SubName: Full=Zgc:165629 protein {ECO:0000313|EMBL:AAI42914.1}; GN Name=ccr7 {ECO:0000313|ZFIN:ZDB-GENE-060522-2}; GN ORFNames=zgc:165629 {ECO:0000313|EMBL:AAI42914.1, GN ECO:0000313|RefSeq:NP_001092213.1}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI42914.1}; RN [1] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16365434; RA DeVries M.E., Kelvin A.A., Xu L., Ran L., Robinson J., Kelvin D.J.; RT "Defining the origins and evolution of the chemokine/chemokine receptor RT system."; RL J. Immunol. 176:401-415(2006). RN [2] {ECO:0000313|EMBL:AAI42914.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAI42914.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19022503; RA Liu Y., Chang M.X., Wu S.G., Nie P.; RT "Characterization of C-C chemokine receptor subfamily in teleost fish."; RL Mol. Immunol. 46:498-504(2009). RN [4] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23055828; RA Wu S.Y., Shin J., Sepich D.S., Solnica-Krezel L.; RT "Chemokine GPCR signaling inhibits beta-catenin during zebrafish axis RT formation."; RL PLoS Biol. 10:e1001403-e1001403(2012). RN [5] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23145839; RA Nomiyama H., Osada N., Yoshie O.; RT "Systematic classification of vertebrate chemokines based on conserved RT synteny and evolutionary history."; RL Genes Cells 18:1-16(2013). RN [6] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [7] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25758222; RA Mackay E.W., Apschner A., Schulte-Merker S.; RT "Vitamin K reduces hypermineralisation in zebrafish models of PXE and RT GACI."; RL Development 142:1095-1101(2015). RN [8] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28351983; RA Blaser B.W., Moore J.L., Hagedorn E.J., Li B., Riquelme R., Lichtig A., RA Yang S., Zhou Y., Tamplin O.J., Binder V., Zon L.I.; RT "CXCR1 remodels the vascular niche to promote hematopoietic stem and RT progenitor cell engraftment."; RL J. Exp. Med. 214:1011-1027(2017). RN [9] {ECO:0000313|RefSeq:NP_001092213.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29873633; RA Malhotra D., Shin J., Solnica-Krezel L., Raz E.; RT "Spatio-temporal regulation of concurrent developmental processes by RT generic signaling downstream of chemokine receptors."; RL Elife 7:e33574-e33574(2018). RN [10] {ECO:0000313|RefSeq:NP_001092213.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early CC endosome {ECO:0000256|ARBA:ARBA00004412}. Endosome CC {ECO:0000256|ARBA:ARBA00004177}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC142913; AAI42914.1; -; mRNA. DR RefSeq; NP_001092213.1; NM_001098743.1. DR GeneID; 565958; -. DR KEGG; dre:565958; -. DR AGR; ZFIN:ZDB-GENE-060522-2; -. DR CTD; 1236; -. DR ZFIN; ZDB-GENE-060522-2; ccr7. DR OrthoDB; 5358146at2759; -. DR PhylomeDB; A5PLI3; -. DR Proteomes; UP000000437; Chromosome 6. DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central. DR GO; GO:0038117; F:C-C motif chemokine 19 receptor activity; IBA:GO_Central. DR GO; GO:0035757; F:chemokine (C-C motif) ligand 19 binding; IBA:GO_Central. DR GO; GO:0035758; F:chemokine (C-C motif) ligand 21 binding; IBA:GO_Central. DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:ZFIN. DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central. DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN. DR GO; GO:0006955; P:immune response; IBA:GO_Central. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:ZFIN. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR CDD; cd15175; 7tmA_CCR7; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR001277; CXCR4/ACKR2. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF635; C-C CHEMOKINE RECEPTOR TYPE 7; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00645; CXCCHMKINER4. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000313|RefSeq:NP_001092213.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001092213.1}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..372 FT /evidence="ECO:0000256|SAM:SignalP, FT ECO:0000313|RefSeq:NP_001092213.1" FT /id="PRO_5035034724" FT TRANSMEM 65..90 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 102..121 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 141..162 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 183..205 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 225..251 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 263..282 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 302..325 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 81..322 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 372 AA; 42515 MW; 91F76238586FF0DB CRC64; MHAYTVFCPV LLIWSCHIKK SWSNMTEHQM GEKATTEYDY TTGTVDYDIY EQSCNKTNNR TFRAWFLPTI YTIICLLALM GNFLVILTYL YFKRLKTMTD VYLFNLAMAD LLFAISLPFW AASFMSTWHL GLYPCKAMFT IYKVSFFSGM FLLTCISIDR YFSITKAVSA HRCRSSAVYY GQVSSLVTWV IAIVFSVPDM VFAVINSRGT CSANVNYQDY YVKMVISQMV LGFIIPAVVM GFCYICIIKT LMQAKNFERN KAFKVIIAVV VVFVFSQLPY NVVMGVSVQQ TTDCAKDNTR LFALDVTMAV AFLRCCVNPF LYAFIGVKFR NDLLKLLKDL GCLRTSHLMY THCGRRRSSV GLDTETTTTF SP //