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A5PL98

- SDHB_DANRE

UniProt

A5PL98 - SDHB_DANRE

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.By similarity
Binds 1 3Fe-4S cluster.By similarity
Binds 1 4Fe-4S cluster.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi92 – 921Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi97 – 971Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi112 – 1121Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi185 – 1851Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi191 – 1911Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi195 – 1951Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei200 – 2001Ubiquinone; shared with dhsdBy similarity
Metal bindingi242 – 2421Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi248 – 2481Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  7. ubiquinone binding Source: UniProtKB

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdhb
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-030131-8005. sdhb.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex II Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionBy similarityAdd
BLAST
Chaini26 – 280255Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000343801Add
BLAST

Proteomic databases

PRIDEiA5PL98.

Expressioni

Gene expression databases

BgeeiA5PL98.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062263.

Structurei

3D structure databases

ProteinModelPortaliA5PL98.
SMRiA5PL98. Positions 36-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 129912Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini175 – 205314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
GeneTreeiENSGT00390000013558.
HOGENOMiHOG000160590.
HOVERGENiHBG005483.
InParanoidiA5PL98.
KOiK00235.
OMAiIMNCSRT.
OrthoDBiEOG7H4DTN.
PhylomeDBiA5PL98.
TreeFamiTF300754.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PL98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT
60 70 80 90 100
VGDKPRMQTY EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC
110 120 130 140 150
AMNINGGNTL ACLNKIDTNT SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK
160 170 180 190 200
SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD GLYECILCAC CSTSCPSYWW
210 220 230 240 250
NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY RCHTIMNCTR
260 270 280
TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA
Length:280
Mass (Da):31,740
Last modified:July 10, 2007 - v1
Checksum:iA16A68A72849B844
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142799 mRNA. Translation: AAI42800.1.
RefSeqiNP_001092210.1. NM_001098740.1.
UniGeneiDr.75182.

Genome annotation databases

EnsembliENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768.
GeneIDi562149.
KEGGidre:562149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142799 mRNA. Translation: AAI42800.1 .
RefSeqi NP_001092210.1. NM_001098740.1.
UniGenei Dr.75182.

3D structure databases

ProteinModelPortali A5PL98.
SMRi A5PL98. Positions 36-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000062263.

Proteomic databases

PRIDEi A5PL98.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000062264 ; ENSDARP00000062263 ; ENSDARG00000075768 .
GeneIDi 562149.
KEGGi dre:562149.

Organism-specific databases

CTDi 6390.
ZFINi ZDB-GENE-030131-8005. sdhb.

Phylogenomic databases

eggNOGi COG0479.
GeneTreei ENSGT00390000013558.
HOGENOMi HOG000160590.
HOVERGENi HBG005483.
InParanoidi A5PL98.
KOi K00235.
OMAi IMNCSRT.
OrthoDBi EOG7H4DTN.
PhylomeDBi A5PL98.
TreeFami TF300754.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Miscellaneous databases

NextBioi 20884271.
PROi A5PL98.

Gene expression databases

Bgeei A5PL98.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiSDHB_DANRE
AccessioniPrimary (citable) accession number: A5PL98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3