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A5PL98

- SDHB_DANRE

UniProt

A5PL98 - SDHB_DANRE

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi92 – 921Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi97 – 971Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi100 – 1001Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi112 – 1121Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi185 – 1851Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi188 – 1881Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi191 – 1911Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi195 – 1951Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei200 – 2001Ubiquinone; shared with dhsdBy similarity
    Metal bindingi242 – 2421Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi248 – 2481Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi252 – 2521Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    7. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:sdhb
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 22

    Organism-specific databases

    ZFINiZDB-GENE-030131-8005. sdhb.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionBy similarityAdd
    BLAST
    Chaini26 – 280255Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000343801Add
    BLAST

    Proteomic databases

    PRIDEiA5PL98.

    Expressioni

    Gene expression databases

    BgeeiA5PL98.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.By similarity

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000062263.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PL98.
    SMRiA5PL98. Positions 36-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 129912Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini175 – 205314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    GeneTreeiENSGT00390000013558.
    HOGENOMiHOG000160590.
    HOVERGENiHBG005483.
    KOiK00235.
    OMAiIMNCSRT.
    OrthoDBiEOG7H4DTN.
    PhylomeDBiA5PL98.
    TreeFamiTF300754.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5PL98-1 [UniParc]FASTAAdd to Basket

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    MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT    50
    VGDKPRMQTY EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC 100
    AMNINGGNTL ACLNKIDTNT SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK 150
    SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD GLYECILCAC CSTSCPSYWW 200
    NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY RCHTIMNCTR 250
    TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA 280
    Length:280
    Mass (Da):31,740
    Last modified:July 10, 2007 - v1
    Checksum:iA16A68A72849B844
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142799 mRNA. Translation: AAI42800.1.
    RefSeqiNP_001092210.1. NM_001098740.1.
    UniGeneiDr.75182.

    Genome annotation databases

    EnsembliENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768.
    GeneIDi562149.
    KEGGidre:562149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142799 mRNA. Translation: AAI42800.1 .
    RefSeqi NP_001092210.1. NM_001098740.1.
    UniGenei Dr.75182.

    3D structure databases

    ProteinModelPortali A5PL98.
    SMRi A5PL98. Positions 36-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000062263.

    Proteomic databases

    PRIDEi A5PL98.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000062264 ; ENSDARP00000062263 ; ENSDARG00000075768 .
    GeneIDi 562149.
    KEGGi dre:562149.

    Organism-specific databases

    CTDi 6390.
    ZFINi ZDB-GENE-030131-8005. sdhb.

    Phylogenomic databases

    eggNOGi COG0479.
    GeneTreei ENSGT00390000013558.
    HOGENOMi HOG000160590.
    HOVERGENi HBG005483.
    KOi K00235.
    OMAi IMNCSRT.
    OrthoDBi EOG7H4DTN.
    PhylomeDBi A5PL98.
    TreeFami TF300754.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Miscellaneous databases

    NextBioi 20884271.
    PROi A5PL98.

    Gene expression databases

    Bgeei A5PL98.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiSDHB_DANRE
    AccessioniPrimary (citable) accession number: A5PL98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3