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A5PL98 (SDHB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhb
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2525Mitochondrion By similarity
Chain26 – 280255Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000343801

Regions

Domain39 – 129912Fe-2S ferredoxin-type
Domain175 – 205314Fe-4S ferredoxin-type

Sites

Metal binding921Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding971Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1121Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1851Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1881Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1911Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1951Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2421Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2481Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2521Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2001Ubiquinone; shared with dhsd By similarity

Sequences

Sequence LengthMass (Da)Tools
A5PL98 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: A16A68A72849B844

FASTA28031,740
        10         20         30         40         50         60 
MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT VGDKPRMQTY 

        70         80         90        100        110        120 
EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC AMNINGGNTL ACLNKIDTNT 

       130        140        150        160        170        180 
SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD 

       190        200        210        220        230        240 
GLYECILCAC CSTSCPSYWW NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY 

       250        260        270        280 
RCHTIMNCTR TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC142799 mRNA. Translation: AAI42800.1.
RefSeqNP_001092210.1. NM_001098740.1.
UniGeneDr.75182.

3D structure databases

ProteinModelPortalA5PL98.
SMRA5PL98. Positions 36-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000062263.

Proteomic databases

PRIDEA5PL98.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768.
GeneID562149.
KEGGdre:562149.

Organism-specific databases

CTD6390.
ZFINZDB-GENE-030131-8005. sdhb.

Phylogenomic databases

eggNOGCOG0479.
GeneTreeENSGT00390000013558.
HOGENOMHOG000160590.
HOVERGENHBG005483.
KOK00235.
OMAIMNCSRT.
OrthoDBEOG7H4DTN.
PhylomeDBA5PL98.
TreeFamTF300754.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Gene expression databases

BgeeA5PL98.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20884271.
PROA5PL98.

Entry information

Entry nameSDHB_DANRE
AccessionPrimary (citable) accession number: A5PL98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways