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Protein

Protein KRBA1

Gene

KRBA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KRBA1
Gene namesi
Name:KRBA1
Synonyms:KIAA1862
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000133619.17
HGNCiHGNC:22228 KRBA1
neXtProtiNX_A5PL33

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133619
PharmGKBiPA162393641

Polymorphism and mutation databases

BioMutaiKRBA1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003001111 – 1030Protein KRBA1Add BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA5PL33
PRIDEiA5PL33

PTM databases

iPTMnetiA5PL33
PhosphoSitePlusiA5PL33

Expressioni

Tissue specificityi

Expressed in brain (cerebellum).1 Publication

Gene expression databases

BgeeiENSG00000133619
CleanExiHS_KRBA1
ExpressionAtlasiA5PL33 baseline and differential
GenevisibleiA5PL33 HS

Organism-specific databases

HPAiHPA021237
HPA050448

Interactioni

Protein-protein interaction databases

BioGridi124155, 24 interactors
IntActiA5PL33, 5 interactors
MINTiA5PL33
STRINGi9606.ENSP00000255992

Structurei

3D structure databases

ProteinModelPortaliA5PL33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili799 – 832Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 107Poly-Ala4
Compositional biasi465 – 471Poly-Ser7
Compositional biasi602 – 792Pro-richAdd BLAST191
Compositional biasi913 – 1002Pro-richAdd BLAST90

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZE Eukaryota
ENOG411141X LUCA
GeneTreeiENSGT00390000006211
HOGENOMiHOG000169555
HOVERGENiHBG099560
InParanoidiA5PL33

Family and domain databases

InterProiView protein in InterPro
IPR029317 KRBA1
PfamiView protein in Pfam
PF15287 KRBA1, 6 hits
SMARTiView protein in SMART
SM01258 KRBA1, 6 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5PL33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP
60 70 80 90 100
QGGQPRHSLH LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA
110 120 130 140 150
SPEAAAAREP CPLRGLLSCL PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG
160 170 180 190 200
SPLPIKTADK PWPTRKEGPG ALGGEPSPPT HSPSRRKSHR GQERGTSEAG
210 220 230 240 250
ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG TSRLTRADLG
260 270 280 290 300
PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN
310 320 330 340 350
PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG
360 370 380 390 400
RQPLSPSATG DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS
410 420 430 440 450
PSQLPPTSCS QNPQPGDSRS QKPELQPHRS HSEEATREPV LPLGLQSCVR
460 470 480 490 500
DGPSRPLAPR GTPTSFSSSS STDWDLDFGS PVGNQGQHPG KGSPPGSSPL
510 520 530 540 550
QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD KEGLRAEACE
560 570 580 590 600
SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW
610 620 630 640 650
LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG
660 670 680 690 700
SEGEDPRPEP DLWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE
710 720 730 740 750
DPRRTEPRYC SGLGAGTAQD PCPVSQLEKR PRVSEASRGL ELGHGRPRVA
760 770 780 790 800
AKTHERLLPQ GPPELPSESP PPELPPPEAA PPVLPASSLQ PPCHCGKPLQ
810 820 830 840 850
QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR RPQGPGPMGQ
860 870 880 890 900
ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL
910 920 930 940 950
QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL
960 970 980 990 1000
LAHTGGHQSP LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK
1010 1020 1030
EPSSLLGGVQ RALQEELWGG EHRDPRWGAH
Length:1,030
Mass (Da):107,498
Last modified:October 31, 2012 - v3
Checksum:iD4493A910C44D41E
GO
Isoform 2 (identifier: A5PL33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Missing.

Show »
Length:1,029
Mass (Da):107,427
Checksum:i78078843703167E6
GO
Isoform 3 (identifier: A5PL33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-603: Missing.

Show »
Length:969
Mass (Da):100,900
Checksum:iB0A107EAC191BEDD
GO

Sequence cautioni

The sequence BAB47491 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056922320H → R. Corresponds to variant dbSNP:rs7791608Ensembl.1
Natural variantiVAR_068701661D → E3 PublicationsCorresponds to variant dbSNP:rs709065Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027780106Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_027779543 – 603Missing in isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058765 mRNA Translation: BAB47491.2 Different initiation.
AC004897 Genomic DNA No translation available.
CH471146 Genomic DNA Translation: EAW80035.1
BC033229 mRNA Translation: AAH33229.1
BC041587 mRNA Translation: AAH41587.1
BC142722 mRNA Translation: AAI42723.1
BC146667 mRNA Translation: AAI46668.1
BC150330 mRNA Translation: AAI50331.1
BC152409 mRNA Translation: AAI52410.1
CCDSiCCDS75674.1 [A5PL33-1]
RefSeqiNP_001277116.1, NM_001290187.1
NP_115923.2, NM_032534.3 [A5PL33-1]
UniGeneiHs.299560

Genome annotation databases

EnsembliENST00000319551; ENSP00000317165; ENSG00000133619 [A5PL33-1]
ENST00000485033; ENSP00000420112; ENSG00000133619 [A5PL33-3]
GeneIDi84626
KEGGihsa:84626
UCSCiuc033api.1 human [A5PL33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKRBA1_HUMAN
AccessioniPrimary (citable) accession number: A5PL33
Secondary accession number(s): A7E2F5
, E7ENE9, Q8N4X0, Q96JG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 31, 2012
Last modified: February 28, 2018
This is version 79 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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