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Protein

Protein KRBA1

Gene

KRBA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KRBA1
Gene namesi
Name:KRBA1
Synonyms:KIAA1862
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22228. KRBA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162393641.

Polymorphism and mutation databases

BioMutaiKRBA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10301030Protein KRBA1PRO_0000300111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei253 – 2531PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA5PL33.
PRIDEiA5PL33.

PTM databases

iPTMnetiA5PL33.
PhosphoSiteiA5PL33.

Expressioni

Tissue specificityi

Expressed in brain (cerebellum).1 Publication

Gene expression databases

BgeeiA5PL33.
CleanExiHS_KRBA1.
ExpressionAtlasiA5PL33. baseline and differential.
GenevisibleiA5PL33. HS.

Organism-specific databases

HPAiHPA021237.
HPA050448.

Interactioni

Protein-protein interaction databases

BioGridi124155. 24 interactions.
IntActiA5PL33. 4 interactions.
MINTiMINT-7969643.
STRINGi9606.ENSP00000255992.

Structurei

3D structure databases

ProteinModelPortaliA5PL33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili799 – 83234Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Ala
Compositional biasi465 – 4717Poly-Ser
Compositional biasi602 – 792191Pro-richAdd
BLAST
Compositional biasi913 – 100290Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKZE. Eukaryota.
ENOG411141X. LUCA.
GeneTreeiENSGT00390000006211.
HOGENOMiHOG000169555.
HOVERGENiHBG099560.
InParanoidiA5PL33.
OrthoDBiEOG7KM5S7.

Family and domain databases

InterProiIPR029317. KRBA1.
[Graphical view]
PfamiPF15287. KRBA1. 6 hits.
[Graphical view]
SMARTiSM01258. KRBA1. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5PL33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRENYETLVS VGTAELLPLS AFLSPSEPGR AVGGGSHADE GQEPAGCGDP
60 70 80 90 100
QGGQPRHSLH LTALVQLVKE IPEFLFGEVK GAMDSPESES RGASLDGERA
110 120 130 140 150
SPEAAAAREP CPLRGLLSCL PDGPTSQPHL ATTPTDSSCS SGPTGDGVQG
160 170 180 190 200
SPLPIKTADK PWPTRKEGPG ALGGEPSPPT HSPSRRKSHR GQERGTSEAG
210 220 230 240 250
ISPGNSPLQG LINCLKEILV PGPRHPETSP SFLPPLPSLG TSRLTRADLG
260 270 280 290 300
PGSPPWAVKT EAVSGDCPLQ GLLHCLKELP EAQDRHPSPS GVGNRRLQEN
310 320 330 340 350
PGAWKRGSGG PGYLLTPPPH PDLGAGGLLS VKMENSWVQS PPGPASCQPG
360 370 380 390 400
RQPLSPSATG DTRGVPQPSW GPEAQAASAS SSPLEALEAC LKGIPPNGSS
410 420 430 440 450
PSQLPPTSCS QNPQPGDSRS QKPELQPHRS HSEEATREPV LPLGLQSCVR
460 470 480 490 500
DGPSRPLAPR GTPTSFSSSS STDWDLDFGS PVGNQGQHPG KGSPPGSSPL
510 520 530 540 550
QGLENCLKEI PVPVLRPAWP CSSAADRGPR RAEPRNWTAD KEGLRAEACE
560 570 580 590 600
SARLGQGRGE APTRSLHLVS PQVFTSSCVP ACHQRGFKDP GATRPGVWRW
610 620 630 640 650
LPEGSAPKPS PLHCLESALR GILPVRPLRF ACVGGPSPSP SPGSSSSFSG
660 670 680 690 700
SEGEDPRPEP DLWKPLPQER DRLPSCKPPV PLSPCPGGTP AGSSGGSPGE
710 720 730 740 750
DPRRTEPRYC SGLGAGTAQD PCPVSQLEKR PRVSEASRGL ELGHGRPRVA
760 770 780 790 800
AKTHERLLPQ GPPELPSESP PPELPPPEAA PPVLPASSLQ PPCHCGKPLQ
810 820 830 840 850
QELHSLGAAL AEKLDRLATA LAGLAQEVAT MRTQVNRLGR RPQGPGPMGQ
860 870 880 890 900
ASWMWTLPRG PRWAHGPGHR HLPYWRQKGP TRPKPKILRG QGESCRAGDL
910 920 930 940 950
QGLSRGTARR ARPLPPDAPP AEPPGLHCSS SQQLLSSTPS CHAAPPAHPL
960 970 980 990 1000
LAHTGGHQSP LPPLVPAALP LQGASPPAAS ADADVPTSGV APDGIPERPK
1010 1020 1030
EPSSLLGGVQ RALQEELWGG EHRDPRWGAH
Length:1,030
Mass (Da):107,498
Last modified:October 31, 2012 - v3
Checksum:iD4493A910C44D41E
GO
Isoform 2 (identifier: A5PL33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Missing.

Show »
Length:1,029
Mass (Da):107,427
Checksum:i78078843703167E6
GO
Isoform 3 (identifier: A5PL33-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-603: Missing.

Show »
Length:969
Mass (Da):100,900
Checksum:iB0A107EAC191BEDD
GO

Sequence cautioni

The sequence BAB47491.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201H → R.
Corresponds to variant rs7791608 [ dbSNP | Ensembl ].
VAR_056922
Natural varianti661 – 6611D → E.3 Publications
Corresponds to variant rs709065 [ dbSNP | Ensembl ].
VAR_068701

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1061Missing in isoform 2. 1 PublicationVSP_027780
Alternative sequencei543 – 60361Missing in isoform 3. 1 PublicationVSP_027779Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058765 mRNA. Translation: BAB47491.2. Different initiation.
AC004897 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80035.1.
BC033229 mRNA. Translation: AAH33229.1.
BC041587 mRNA. Translation: AAH41587.1.
BC142722 mRNA. Translation: AAI42723.1.
BC146667 mRNA. Translation: AAI46668.1.
BC150330 mRNA. Translation: AAI50331.1.
BC152409 mRNA. Translation: AAI52410.1.
CCDSiCCDS75674.1. [A5PL33-1]
RefSeqiNP_001277116.1. NM_001290187.1.
NP_115923.2. NM_032534.3. [A5PL33-1]
UniGeneiHs.299560.

Genome annotation databases

EnsembliENST00000319551; ENSP00000317165; ENSG00000133619. [A5PL33-1]
ENST00000485033; ENSP00000420112; ENSG00000133619. [A5PL33-3]
GeneIDi84626.
KEGGihsa:84626.
UCSCiuc033api.1. human. [A5PL33-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058765 mRNA. Translation: BAB47491.2. Different initiation.
AC004897 Genomic DNA. No translation available.
CH471146 Genomic DNA. Translation: EAW80035.1.
BC033229 mRNA. Translation: AAH33229.1.
BC041587 mRNA. Translation: AAH41587.1.
BC142722 mRNA. Translation: AAI42723.1.
BC146667 mRNA. Translation: AAI46668.1.
BC150330 mRNA. Translation: AAI50331.1.
BC152409 mRNA. Translation: AAI52410.1.
CCDSiCCDS75674.1. [A5PL33-1]
RefSeqiNP_001277116.1. NM_001290187.1.
NP_115923.2. NM_032534.3. [A5PL33-1]
UniGeneiHs.299560.

3D structure databases

ProteinModelPortaliA5PL33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124155. 24 interactions.
IntActiA5PL33. 4 interactions.
MINTiMINT-7969643.
STRINGi9606.ENSP00000255992.

PTM databases

iPTMnetiA5PL33.
PhosphoSiteiA5PL33.

Polymorphism and mutation databases

BioMutaiKRBA1.

Proteomic databases

PaxDbiA5PL33.
PRIDEiA5PL33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319551; ENSP00000317165; ENSG00000133619. [A5PL33-1]
ENST00000485033; ENSP00000420112; ENSG00000133619. [A5PL33-3]
GeneIDi84626.
KEGGihsa:84626.
UCSCiuc033api.1. human. [A5PL33-1]

Organism-specific databases

CTDi84626.
GeneCardsiKRBA1.
H-InvDBHIX0007193.
HGNCiHGNC:22228. KRBA1.
HPAiHPA021237.
HPA050448.
neXtProtiNX_A5PL33.
PharmGKBiPA162393641.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZE. Eukaryota.
ENOG411141X. LUCA.
GeneTreeiENSGT00390000006211.
HOGENOMiHOG000169555.
HOVERGENiHBG099560.
InParanoidiA5PL33.
OrthoDBiEOG7KM5S7.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii84626.
NextBioi35499600.
PROiA5PL33.

Gene expression databases

BgeeiA5PL33.
CleanExiHS_KRBA1.
ExpressionAtlasiA5PL33. baseline and differential.
GenevisibleiA5PL33. HS.

Family and domain databases

InterProiIPR029317. KRBA1.
[Graphical view]
PfamiPF15287. KRBA1. 6 hits.
[Graphical view]
SMARTiSM01258. KRBA1. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT GLU-661.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-661.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 300-1029 (ISOFORM 3), VARIANT GLU-661.
    Tissue: Pancreas.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiKRBA1_HUMAN
AccessioniPrimary (citable) accession number: A5PL33
Secondary accession number(s): A7E2F5
, E7ENE9, Q8N4X0, Q96JG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 31, 2012
Last modified: May 11, 2016
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.