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A5PKW4

- PSD1_HUMAN

UniProt

A5PKW4 - PSD1_HUMAN

Protein

PH and SEC7 domain-containing protein 1

Gene

PSD

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling By similarity.By similarity

    GO - Molecular functioni

    1. ARF guanyl-nucleotide exchange factor activity Source: RefGenome
    2. phospholipid binding Source: InterPro
    3. protein binding Source: IntAct
    4. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. neuron differentiation Source: RefGenome
    2. positive regulation of GTPase activity Source: GOC
    3. regulation of ARF protein signal transduction Source: InterPro
    4. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PH and SEC7 domain-containing protein 1
    Alternative name(s):
    Exchange factor for ARF6
    Pleckstrin homology and SEC7 domain-containing protein 1
    Gene namesi
    Name:PSD
    Synonyms:EFA6, KIAA2011, PSD1, TYL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9507. PSD.

    Subcellular locationi

    Cell membrane By similarity. Cell projectionruffle By similarity

    GO - Cellular componenti

    1. cell junction Source: RefGenome
    2. integral component of membrane Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell
    4. ruffle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33854.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10241024PH and SEC7 domain-containing protein 1PRO_0000318298Add
    BLAST

    Proteomic databases

    PaxDbiA5PKW4.
    PRIDEiA5PKW4.

    PTM databases

    PhosphoSiteiA5PKW4.

    Expressioni

    Tissue specificityi

    Isoform 2 is expressed in the brain.1 Publication

    Gene expression databases

    BgeeiA5PKW4.
    CleanExiHS_PSD.
    GenevestigatoriA5PKW4.

    Organism-specific databases

    HPAiHPA059237.

    Interactioni

    Subunit structurei

    Interacts with ACTN1.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Usp9xP703983EBI-719999,EBI-2214043From a different organism.

    Protein-protein interaction databases

    BioGridi111641. 2 interactions.
    IntActiA5PKW4. 12 interactions.
    MINTiMINT-7897159.
    STRINGi9606.ENSP00000020673.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PKW4.
    SMRiA5PKW4. Positions 559-709.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini512 – 706195SEC7PROSITE-ProRule annotationAdd
    BLAST
    Domaini756 – 869114PHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili898 – 92427Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 181164Pro-richAdd
    BLAST
    Compositional biasi432 – 46635Pro-richAdd
    BLAST
    Compositional biasi483 – 4886Poly-Glu

    Sequence similaritiesi

    Belongs to the PSD family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 SEC7 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5307.
    HOGENOMiHOG000060162.
    HOVERGENiHBG106661.
    InParanoidiA5PKW4.
    KOiK12494.
    OMAiFEKSRYS.
    OrthoDBiEOG7G7KNS.
    PhylomeDBiA5PKW4.
    TreeFamiTF319755.

    Family and domain databases

    Gene3Di1.10.1000.11. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR001605. PH_dom-spectrin-type.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR023394. Sec7_alpha_orthog.
    IPR000904. Sec7_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    PF01369. Sec7. 1 hit.
    [Graphical view]
    PRINTSiPR00683. SPECTRINPH.
    SMARTiSM00233. PH. 1 hit.
    SM00222. Sec7. 1 hit.
    [Graphical view]
    SUPFAMiSSF48425. SSF48425. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS50190. SEC7. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms may exist.

    Isoform 1 (identifier: A5PKW4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV     50
    AGPGPRGREL GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV 100
    VIFRFVEKAS VRPLNGLPAP GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR 150
    LEASTSDPLP ARGGSALPGS RNLVHGPPAP PQVGADGLYS SLPNGLGGPP 200
    ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDPP 250
    SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD 300
    IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE 350
    DEDDDEAGGE EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD 400
    SFSCVFEAIL ESHRAKGTSY TSLASLEALA SPGPTQSPFF TFELPPQPPA 450
    PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RGEEEEAEAR AKLAPGREPP 500
    SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG 550
    QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF 600
    TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA 650
    HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY 700
    SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRISGGSG SGSSPFLDLT 750
    PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE 800
    EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ 850
    APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ 900
    EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS 950
    RYSTYAALLR VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP 1000
    SSQPRAQRHS SEPRPGAGSG RRKP 1024
    Length:1,024
    Mass (Da):109,543
    Last modified:September 23, 2008 - v2
    Checksum:i74583FEAAB0E4E01
    GO
    Isoform 2 (identifier: A5PKW4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-379: Missing.

    Show »
    Length:645
    Mass (Da):70,393
    Checksum:i547D22FAB7C0D087
    GO

    Sequence cautioni

    The sequence BAC23107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti109 – 1091A → T in CAA68002. (PubMed:9417912)Curated
    Sequence conflicti109 – 1091A → T in AAI42690. (PubMed:15489334)Curated
    Sequence conflicti462 – 4621A → T in CAA68002. (PubMed:9417912)Curated
    Sequence conflicti537 – 5371E → D in CAA68002. (PubMed:9417912)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 379379Missing in isoform 2. 1 PublicationVSP_031186Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99688 mRNA. Translation: CAA68002.1.
    AB095931 mRNA. Translation: BAC23107.1. Different initiation.
    AL121928 Genomic DNA. Translation: CAI12516.1.
    CH471066 Genomic DNA. Translation: EAW49693.1.
    CH471066 Genomic DNA. Translation: EAW49694.1.
    BC142643 mRNA. Translation: AAI42644.1.
    BC142689 mRNA. Translation: AAI42690.1.
    CCDSiCCDS31272.1. [A5PKW4-1]
    PIRiG01205.
    RefSeqiNP_001257894.1. NM_001270965.1. [A5PKW4-1]
    NP_001257895.1. NM_001270966.1. [A5PKW4-2]
    NP_002770.3. NM_002779.4. [A5PKW4-1]
    UniGeneiHs.154658.
    Hs.743732.

    Genome annotation databases

    EnsembliENST00000020673; ENSP00000020673; ENSG00000059915. [A5PKW4-1]
    ENST00000406432; ENSP00000384830; ENSG00000059915. [A5PKW4-1]
    GeneIDi5662.
    KEGGihsa:5662.
    UCSCiuc001kvg.2. human. [A5PKW4-1]
    uc031pxd.1. human. [A5PKW4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99688 mRNA. Translation: CAA68002.1 .
    AB095931 mRNA. Translation: BAC23107.1 . Different initiation.
    AL121928 Genomic DNA. Translation: CAI12516.1 .
    CH471066 Genomic DNA. Translation: EAW49693.1 .
    CH471066 Genomic DNA. Translation: EAW49694.1 .
    BC142643 mRNA. Translation: AAI42644.1 .
    BC142689 mRNA. Translation: AAI42690.1 .
    CCDSi CCDS31272.1. [A5PKW4-1 ]
    PIRi G01205.
    RefSeqi NP_001257894.1. NM_001270965.1. [A5PKW4-1 ]
    NP_001257895.1. NM_001270966.1. [A5PKW4-2 ]
    NP_002770.3. NM_002779.4. [A5PKW4-1 ]
    UniGenei Hs.154658.
    Hs.743732.

    3D structure databases

    ProteinModelPortali A5PKW4.
    SMRi A5PKW4. Positions 559-709.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111641. 2 interactions.
    IntActi A5PKW4. 12 interactions.
    MINTi MINT-7897159.
    STRINGi 9606.ENSP00000020673.

    PTM databases

    PhosphoSitei A5PKW4.

    Proteomic databases

    PaxDbi A5PKW4.
    PRIDEi A5PKW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000020673 ; ENSP00000020673 ; ENSG00000059915 . [A5PKW4-1 ]
    ENST00000406432 ; ENSP00000384830 ; ENSG00000059915 . [A5PKW4-1 ]
    GeneIDi 5662.
    KEGGi hsa:5662.
    UCSCi uc001kvg.2. human. [A5PKW4-1 ]
    uc031pxd.1. human. [A5PKW4-2 ]

    Organism-specific databases

    CTDi 5662.
    GeneCardsi GC10M104152.
    H-InvDB HIX0025909.
    HGNCi HGNC:9507. PSD.
    HPAi HPA059237.
    MIMi 602327. gene.
    neXtProti NX_A5PKW4.
    PharmGKBi PA33854.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5307.
    HOGENOMi HOG000060162.
    HOVERGENi HBG106661.
    InParanoidi A5PKW4.
    KOi K12494.
    OMAi FEKSRYS.
    OrthoDBi EOG7G7KNS.
    PhylomeDBi A5PKW4.
    TreeFami TF319755.

    Miscellaneous databases

    ChiTaRSi PSD. human.
    GenomeRNAii 5662.
    NextBioi 22002.
    PROi A5PKW4.
    SOURCEi Search...

    Gene expression databases

    Bgeei A5PKW4.
    CleanExi HS_PSD.
    Genevestigatori A5PKW4.

    Family and domain databases

    Gene3Di 1.10.1000.11. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR001605. PH_dom-spectrin-type.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR023394. Sec7_alpha_orthog.
    IPR000904. Sec7_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    PF01369. Sec7. 1 hit.
    [Graphical view ]
    PRINTSi PR00683. SPECTRINPH.
    SMARTi SM00233. PH. 1 hit.
    SM00222. Sec7. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48425. SSF48425. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS50190. SEC7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains."
      Perletti L., Talarico D., Trecca D., Ronchetti D., Fracchiolla N.S., Maiolo A.T., Neri A.
      Genomics 46:251-259(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "The nucleotide sequence of a long cDNA clone isolated from human."
      Nagase T., Kikuno R., Ohara O.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiPSD1_HUMAN
    AccessioniPrimary (citable) accession number: A5PKW4
    Secondary accession number(s): B1AKX7
    , D3DR87, Q15673, Q8IVG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3