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A5PKW4

- PSD1_HUMAN

UniProt

A5PKW4 - PSD1_HUMAN

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Protein
PH and SEC7 domain-containing protein 1
Gene
PSD, EFA6, KIAA2011, PSD1, TYL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling By similarity.

GO - Molecular functioni

  1. ARF guanyl-nucleotide exchange factor activity Source: RefGenome
  2. phospholipid binding Source: InterPro
  3. protein binding Source: IntAct
  4. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. neuron differentiation Source: RefGenome
  2. regulation of ARF protein signal transduction Source: InterPro
  3. regulation of GTPase activity Source: GOC
  4. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 1
Alternative name(s):
Exchange factor for ARF6
Pleckstrin homology and SEC7 domain-containing protein 1
Gene namesi
Name:PSD
Synonyms:EFA6, KIAA2011, PSD1, TYL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:9507. PSD.

Subcellular locationi

Cell membrane By similarity. Cell projectionruffle By similarity

GO - Cellular componenti

  1. cell junction Source: RefGenome
  2. integral component of membrane Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
  4. ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10241024PH and SEC7 domain-containing protein 1
PRO_0000318298Add
BLAST

Proteomic databases

PaxDbiA5PKW4.
PRIDEiA5PKW4.

PTM databases

PhosphoSiteiA5PKW4.

Expressioni

Tissue specificityi

Isoform 2 is expressed in the brain.1 Publication

Gene expression databases

BgeeiA5PKW4.
CleanExiHS_PSD.
GenevestigatoriA5PKW4.

Organism-specific databases

HPAiHPA059237.

Interactioni

Subunit structurei

Interacts with ACTN1 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Usp9xP703983EBI-719999,EBI-2214043From a different organism.

Protein-protein interaction databases

BioGridi111641. 2 interactions.
IntActiA5PKW4. 12 interactions.
MINTiMINT-7897159.
STRINGi9606.ENSP00000020673.

Structurei

3D structure databases

ProteinModelPortaliA5PKW4.
SMRiA5PKW4. Positions 559-709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini512 – 706195SEC7
Add
BLAST
Domaini756 – 869114PH
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili898 – 92427 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 181164Pro-rich
Add
BLAST
Compositional biasi432 – 46635Pro-rich
Add
BLAST
Compositional biasi483 – 4886Poly-Glu

Sequence similaritiesi

Belongs to the PSD family.
Contains 1 PH domain.
Contains 1 SEC7 domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5307.
HOGENOMiHOG000060162.
HOVERGENiHBG106661.
InParanoidiA5PKW4.
KOiK12494.
OMAiFEKSRYS.
OrthoDBiEOG7G7KNS.
PhylomeDBiA5PKW4.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Note: Additional isoforms may exist.

Isoform 1 (identifier: A5PKW4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV     50
AGPGPRGREL GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV 100
VIFRFVEKAS VRPLNGLPAP GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR 150
LEASTSDPLP ARGGSALPGS RNLVHGPPAP PQVGADGLYS SLPNGLGGPP 200
ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDPP 250
SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD 300
IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE 350
DEDDDEAGGE EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD 400
SFSCVFEAIL ESHRAKGTSY TSLASLEALA SPGPTQSPFF TFELPPQPPA 450
PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RGEEEEAEAR AKLAPGREPP 500
SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG 550
QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF 600
TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA 650
HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY 700
SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRISGGSG SGSSPFLDLT 750
PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE 800
EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ 850
APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ 900
EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS 950
RYSTYAALLR VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP 1000
SSQPRAQRHS SEPRPGAGSG RRKP 1024
Length:1,024
Mass (Da):109,543
Last modified:September 23, 2008 - v2
Checksum:i74583FEAAB0E4E01
GO
Isoform 2 (identifier: A5PKW4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Show »
Length:645
Mass (Da):70,393
Checksum:i547D22FAB7C0D087
GO

Sequence cautioni

The sequence BAC23107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 379379Missing in isoform 2.
VSP_031186Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091A → T in CAA68002. 1 Publication
Sequence conflicti109 – 1091A → T in AAI42690. 1 Publication
Sequence conflicti462 – 4621A → T in CAA68002. 1 Publication
Sequence conflicti537 – 5371E → D in CAA68002. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99688 mRNA. Translation: CAA68002.1.
AB095931 mRNA. Translation: BAC23107.1. Different initiation.
AL121928 Genomic DNA. Translation: CAI12516.1.
CH471066 Genomic DNA. Translation: EAW49693.1.
CH471066 Genomic DNA. Translation: EAW49694.1.
BC142643 mRNA. Translation: AAI42644.1.
BC142689 mRNA. Translation: AAI42690.1.
CCDSiCCDS31272.1. [A5PKW4-1]
PIRiG01205.
RefSeqiNP_001257894.1. NM_001270965.1. [A5PKW4-1]
NP_001257895.1. NM_001270966.1. [A5PKW4-2]
NP_002770.3. NM_002779.4. [A5PKW4-1]
UniGeneiHs.154658.
Hs.743732.

Genome annotation databases

EnsembliENST00000020673; ENSP00000020673; ENSG00000059915. [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915. [A5PKW4-1]
GeneIDi5662.
KEGGihsa:5662.
UCSCiuc001kvg.2. human. [A5PKW4-1]
uc031pxd.1. human. [A5PKW4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99688 mRNA. Translation: CAA68002.1 .
AB095931 mRNA. Translation: BAC23107.1 . Different initiation.
AL121928 Genomic DNA. Translation: CAI12516.1 .
CH471066 Genomic DNA. Translation: EAW49693.1 .
CH471066 Genomic DNA. Translation: EAW49694.1 .
BC142643 mRNA. Translation: AAI42644.1 .
BC142689 mRNA. Translation: AAI42690.1 .
CCDSi CCDS31272.1. [A5PKW4-1 ]
PIRi G01205.
RefSeqi NP_001257894.1. NM_001270965.1. [A5PKW4-1 ]
NP_001257895.1. NM_001270966.1. [A5PKW4-2 ]
NP_002770.3. NM_002779.4. [A5PKW4-1 ]
UniGenei Hs.154658.
Hs.743732.

3D structure databases

ProteinModelPortali A5PKW4.
SMRi A5PKW4. Positions 559-709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111641. 2 interactions.
IntActi A5PKW4. 12 interactions.
MINTi MINT-7897159.
STRINGi 9606.ENSP00000020673.

PTM databases

PhosphoSitei A5PKW4.

Proteomic databases

PaxDbi A5PKW4.
PRIDEi A5PKW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000020673 ; ENSP00000020673 ; ENSG00000059915 . [A5PKW4-1 ]
ENST00000406432 ; ENSP00000384830 ; ENSG00000059915 . [A5PKW4-1 ]
GeneIDi 5662.
KEGGi hsa:5662.
UCSCi uc001kvg.2. human. [A5PKW4-1 ]
uc031pxd.1. human. [A5PKW4-2 ]

Organism-specific databases

CTDi 5662.
GeneCardsi GC10M104152.
H-InvDB HIX0025909.
HGNCi HGNC:9507. PSD.
HPAi HPA059237.
MIMi 602327. gene.
neXtProti NX_A5PKW4.
PharmGKBi PA33854.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5307.
HOGENOMi HOG000060162.
HOVERGENi HBG106661.
InParanoidi A5PKW4.
KOi K12494.
OMAi FEKSRYS.
OrthoDBi EOG7G7KNS.
PhylomeDBi A5PKW4.
TreeFami TF319755.

Miscellaneous databases

ChiTaRSi PSD. human.
GenomeRNAii 5662.
NextBioi 22002.
PROi A5PKW4.
SOURCEi Search...

Gene expression databases

Bgeei A5PKW4.
CleanExi HS_PSD.
Genevestigatori A5PKW4.

Family and domain databases

Gene3Di 1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view ]
PRINTSi PR00683. SPECTRINPH.
SMARTi SM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view ]
SUPFAMi SSF48425. SSF48425. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains."
    Perletti L., Talarico D., Trecca D., Ronchetti D., Fracchiolla N.S., Maiolo A.T., Neri A.
    Genomics 46:251-259(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The nucleotide sequence of a long cDNA clone isolated from human."
    Nagase T., Kikuno R., Ohara O.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiPSD1_HUMAN
AccessioniPrimary (citable) accession number: A5PKW4
Secondary accession number(s): B1AKX7
, D3DR87, Q15673, Q8IVG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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