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A5PKW4 (PSD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PH and SEC7 domain-containing protein 1
Alternative name(s):
Exchange factor for ARF6
Pleckstrin homology and SEC7 domain-containing protein 1
Gene names
Name:PSD
Synonyms:EFA6, KIAA2011, PSD1, TYL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1024 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling By similarity.

Subunit structure

Interacts with ACTN1 By similarity.

Subcellular location

Cell membrane By similarity. Cell projectionruffle By similarity.

Tissue specificity

Isoform 2 is expressed in the brain. Ref.1

Sequence similarities

Belongs to the PSD family.

Contains 1 PH domain.

Contains 1 SEC7 domain.

Sequence caution

The sequence BAC23107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Usp9xP703983EBI-719999,EBI-2214043From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms may exist.
Isoform 1 (identifier: A5PKW4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A5PKW4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10241024PH and SEC7 domain-containing protein 1
PRO_0000318298

Regions

Domain512 – 706195SEC7
Domain756 – 869114PH
Coiled coil898 – 92427 Potential
Compositional bias18 – 181164Pro-rich
Compositional bias432 – 46635Pro-rich
Compositional bias483 – 4886Poly-Glu

Natural variations

Alternative sequence1 – 379379Missing in isoform 2.
VSP_031186

Experimental info

Sequence conflict1091A → T in CAA68002. Ref.1
Sequence conflict1091A → T in AAI42690. Ref.5
Sequence conflict4621A → T in CAA68002. Ref.1
Sequence conflict5371E → D in CAA68002. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: 74583FEAAB0E4E01

FASTA1,024109,543
        10         20         30         40         50         60 
MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV AGPGPRGREL 

        70         80         90        100        110        120 
GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV VIFRFVEKAS VRPLNGLPAP 

       130        140        150        160        170        180 
GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR LEASTSDPLP ARGGSALPGS RNLVHGPPAP 

       190        200        210        220        230        240 
PQVGADGLYS SLPNGLGGPP ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW 

       250        260        270        280        290        300 
EFFYGSLDPP SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD 

       310        320        330        340        350        360 
IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE DEDDDEAGGE 

       370        380        390        400        410        420 
EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD SFSCVFEAIL ESHRAKGTSY 

       430        440        450        460        470        480 
TSLASLEALA SPGPTQSPFF TFELPPQPPA PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ 

       490        500        510        520        530        540 
RGEEEEAEAR AKLAPGREPP SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA 

       550        560        570        580        590        600 
LGSTDTLSNG QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF 

       610        620        630        640        650        660 
TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA HTLTCALMLL 

       670        680        690        700        710        720 
NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY SSIKNEKLQW AIDEEELRRS 

       730        740        750        760        770        780 
LSELADPNPK VIKRISGGSG SGSSPFLDLT PEPGAAVYKH GALVRKVHAD PDCRKTPRGK 

       790        800        810        820        830        840 
RGWKSFHGIL KGMILYLQKE EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR 

       850        860        870        880        890        900 
TADWRVFLFQ APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ 

       910        920        930        940        950        960 
EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS RYSTYAALLR 

       970        980        990       1000       1010       1020 
VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP SSQPRAQRHS SEPRPGAGSG 


RRKP 

« Hide

Isoform 2 [UniParc].

Checksum: 547D22FAB7C0D087
Show »

FASTA64570,393

References

« Hide 'large scale' references
[1]"Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains."
Perletti L., Talarico D., Trecca D., Ronchetti D., Fracchiolla N.S., Maiolo A.T., Neri A.
Genomics 46:251-259(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Brain.
[2]"The nucleotide sequence of a long cDNA clone isolated from human."
Nagase T., Kikuno R., Ohara O.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99688 mRNA. Translation: CAA68002.1.
AB095931 mRNA. Translation: BAC23107.1. Different initiation.
AL121928 Genomic DNA. Translation: CAI12516.1.
CH471066 Genomic DNA. Translation: EAW49693.1.
CH471066 Genomic DNA. Translation: EAW49694.1.
BC142643 mRNA. Translation: AAI42644.1.
BC142689 mRNA. Translation: AAI42690.1.
PIRG01205.
RefSeqNP_001257894.1. NM_001270965.1.
NP_001257895.1. NM_001270966.1.
NP_002770.3. NM_002779.4.
UniGeneHs.154658.
Hs.743732.

3D structure databases

ProteinModelPortalA5PKW4.
SMRA5PKW4. Positions 557-972.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111641. 2 interactions.
IntActA5PKW4. 12 interactions.
MINTMINT-7897159.
STRING9606.ENSP00000020673.

PTM databases

PhosphoSiteA5PKW4.

Proteomic databases

PaxDbA5PKW4.
PRIDEA5PKW4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000020673; ENSP00000020673; ENSG00000059915. [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915. [A5PKW4-1]
GeneID5662.
KEGGhsa:5662.
UCSCuc001kvg.2. human. [A5PKW4-1]
uc031pxd.1. human. [A5PKW4-2]

Organism-specific databases

CTD5662.
GeneCardsGC10M104152.
H-InvDBHIX0025909.
HGNCHGNC:9507. PSD.
HPAHPA059237.
MIM602327. gene.
neXtProtNX_A5PKW4.
PharmGKBPA33854.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5307.
HOGENOMHOG000060162.
HOVERGENHBG106661.
InParanoidA5PKW4.
KOK12494.
OMAFEKSRYS.
OrthoDBEOG7G7KNS.
PhylomeDBA5PKW4.
TreeFamTF319755.

Gene expression databases

BgeeA5PKW4.
CleanExHS_PSD.
GenevestigatorA5PKW4.

Family and domain databases

Gene3D1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProIPR001605. PH_dom-spectrin-type.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamPF00169. PH. 1 hit.
PF01369. Sec7. 1 hit.
[Graphical view]
PRINTSPR00683. SPECTRINPH.
SMARTSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMSSF48425. SSF48425. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPSD. human.
GenomeRNAi5662.
NextBio22002.
PROA5PKW4.
SOURCESearch...

Entry information

Entry namePSD1_HUMAN
AccessionPrimary (citable) accession number: A5PKW4
Secondary accession number(s): B1AKX7 expand/collapse secondary AC list , D3DR87, Q15673, Q8IVG0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM