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Protein

PH and SEC7 domain-containing protein 1

Gene

PSD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • regulation of ARF protein signal transduction Source: InterPro
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 1
Alternative name(s):
Exchange factor for ARF6
Pleckstrin homology and SEC7 domain-containing protein 1
Gene namesi
Name:PSD
Synonyms:EFA6, KIAA2011, PSD1, TYL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9507. PSD.

Subcellular locationi

  • Cell membrane By similarity
  • Cell projectionruffle By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5662.
OpenTargetsiENSG00000059915.
PharmGKBiPA33854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003182981 – 1024PH and SEC7 domain-containing protein 1Add BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei720PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA5PKW4.
PRIDEiA5PKW4.

PTM databases

iPTMnetiA5PKW4.
PhosphoSitePlusiA5PKW4.

Expressioni

Tissue specificityi

Isoform 2 is expressed in the brain.1 Publication

Gene expression databases

BgeeiENSG00000059915.
CleanExiHS_PSD.
GenevisibleiA5PKW4. HS.

Organism-specific databases

HPAiHPA059237.

Interactioni

Subunit structurei

Interacts with ACTN1. Interacts (ARF6-bound form) with KCNK1; does not interact with KCNK1 in the absence of ARF6 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Usp9xP703983EBI-719999,EBI-2214043From a different organism.

Protein-protein interaction databases

BioGridi111641. 2 interactors.
IntActiA5PKW4. 12 interactors.
MINTiMINT-7897159.
STRINGi9606.ENSP00000020673.

Structurei

3D structure databases

ProteinModelPortaliA5PKW4.
SMRiA5PKW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini512 – 706SEC7PROSITE-ProRule annotationAdd BLAST195
Domaini756 – 869PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili898 – 924Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 181Pro-richAdd BLAST164
Compositional biasi432 – 466Pro-richAdd BLAST35
Compositional biasi483 – 488Poly-Glu6

Sequence similaritiesi

Belongs to the PSD family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00860000133718.
HOGENOMiHOG000060162.
HOVERGENiHBG106661.
InParanoidiA5PKW4.
KOiK12494.
OMAiDAPWTER.
OrthoDBiEOG091G0187.
PhylomeDBiA5PKW4.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms may exist.
Isoform 1 (identifier: A5PKW4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQGAMRFCS EGDCAISPPR CPRRWLPEGP VPQSPPASMY GSTGSLLRRV
60 70 80 90 100
AGPGPRGREL GRVTAPCTPL RGPPSPRVAP SPWAPSSPTG QPPPGAQSSV
110 120 130 140 150
VIFRFVEKAS VRPLNGLPAP GGLSRSWDLG GVSPPRPTPA LGPGSNRKLR
160 170 180 190 200
LEASTSDPLP ARGGSALPGS RNLVHGPPAP PQVGADGLYS SLPNGLGGPP
210 220 230 240 250
ERLATLFGGP ADTGFLNQGD TWSSPREVSS HAQRIARAKW EFFYGSLDPP
260 270 280 290 300
SSGAKPPEQA PPSPPGVGSR QGSGVAVGRA AKYSETDLDT VPLRCYRETD
310 320 330 340 350
IDEVLAEREE ADSAIESQPS SEGPPGTAYP PAPRPGPLPG PHPSLGSGNE
360 370 380 390 400
DEDDDEAGGE EDVDDEVFEA SEGARPGSRM PLKSPVPFLP GTSPSADGPD
410 420 430 440 450
SFSCVFEAIL ESHRAKGTSY TSLASLEALA SPGPTQSPFF TFELPPQPPA
460 470 480 490 500
PRPDPPAPAP LAPLEPDSGT SSAADGPWTQ RGEEEEAEAR AKLAPGREPP
510 520 530 540 550
SPCHSEDSLG LGAAPLGSEP PLSQLVSDSD SELDSTERLA LGSTDTLSNG
560 570 580 590 600
QKADLEAAQR LAKRLYRLDG FRKADVARHL GKNNDFSKLV AGEYLKFFVF
610 620 630 640 650
TGMTLDQALR VFLKELALMG ETQERERVLA HFSQRYFQCN PEALSSEDGA
660 670 680 690 700
HTLTCALMLL NTDLHGHNIG KRMTCGDFIG NLEGLNDGGD FPRELLKALY
710 720 730 740 750
SSIKNEKLQW AIDEEELRRS LSELADPNPK VIKRISGGSG SGSSPFLDLT
760 770 780 790 800
PEPGAAVYKH GALVRKVHAD PDCRKTPRGK RGWKSFHGIL KGMILYLQKE
810 820 830 840 850
EYKPGKALSE TELKNAISIH HALATRASDY SKRPHVFYLR TADWRVFLFQ
860 870 880 890 900
APSLEQMQSW ITRINVVAAM FSAPPFPAAV SSQKKFSRPL LPSAATRLSQ
910 920 930 940 950
EEQVRTHEAK LKAMASELRE HRAAQLGKKG RGKEAEEQRQ KEAYLEFEKS
960 970 980 990 1000
RYSTYAALLR VKLKAGSEEL DAVEAALAQA GSTEDGLPPS HSSPSLQPKP
1010 1020
SSQPRAQRHS SEPRPGAGSG RRKP
Length:1,024
Mass (Da):109,543
Last modified:September 23, 2008 - v2
Checksum:i74583FEAAB0E4E01
GO
Isoform 2 (identifier: A5PKW4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-379: Missing.

Show »
Length:645
Mass (Da):70,393
Checksum:i547D22FAB7C0D087
GO

Sequence cautioni

The sequence BAC23107 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109A → T in CAA68002 (PubMed:9417912).Curated1
Sequence conflicti109A → T in AAI42690 (PubMed:15489334).Curated1
Sequence conflicti462A → T in CAA68002 (PubMed:9417912).Curated1
Sequence conflicti537E → D in CAA68002 (PubMed:9417912).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311861 – 379Missing in isoform 2. 1 PublicationAdd BLAST379

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99688 mRNA. Translation: CAA68002.1.
AB095931 mRNA. Translation: BAC23107.1. Different initiation.
AL121928 Genomic DNA. Translation: CAI12516.1.
CH471066 Genomic DNA. Translation: EAW49693.1.
CH471066 Genomic DNA. Translation: EAW49694.1.
BC142643 mRNA. Translation: AAI42644.1.
BC142689 mRNA. Translation: AAI42690.1.
CCDSiCCDS31272.1. [A5PKW4-1]
CCDS73187.1. [A5PKW4-2]
PIRiG01205.
RefSeqiNP_001257894.1. NM_001270965.1. [A5PKW4-1]
NP_001257895.1. NM_001270966.1. [A5PKW4-2]
NP_002770.3. NM_002779.4. [A5PKW4-1]
XP_011538270.1. XM_011539968.1. [A5PKW4-1]
XP_011538271.1. XM_011539969.2. [A5PKW4-1]
XP_016871922.1. XM_017016433.1. [A5PKW4-1]
XP_016871923.1. XM_017016434.1. [A5PKW4-1]
UniGeneiHs.154658.
Hs.743732.

Genome annotation databases

EnsembliENST00000020673; ENSP00000020673; ENSG00000059915. [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915. [A5PKW4-1]
ENST00000611678; ENSP00000481250; ENSG00000059915. [A5PKW4-2]
GeneIDi5662.
KEGGihsa:5662.
UCSCiuc001kvg.3. human. [A5PKW4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99688 mRNA. Translation: CAA68002.1.
AB095931 mRNA. Translation: BAC23107.1. Different initiation.
AL121928 Genomic DNA. Translation: CAI12516.1.
CH471066 Genomic DNA. Translation: EAW49693.1.
CH471066 Genomic DNA. Translation: EAW49694.1.
BC142643 mRNA. Translation: AAI42644.1.
BC142689 mRNA. Translation: AAI42690.1.
CCDSiCCDS31272.1. [A5PKW4-1]
CCDS73187.1. [A5PKW4-2]
PIRiG01205.
RefSeqiNP_001257894.1. NM_001270965.1. [A5PKW4-1]
NP_001257895.1. NM_001270966.1. [A5PKW4-2]
NP_002770.3. NM_002779.4. [A5PKW4-1]
XP_011538270.1. XM_011539968.1. [A5PKW4-1]
XP_011538271.1. XM_011539969.2. [A5PKW4-1]
XP_016871922.1. XM_017016433.1. [A5PKW4-1]
XP_016871923.1. XM_017016434.1. [A5PKW4-1]
UniGeneiHs.154658.
Hs.743732.

3D structure databases

ProteinModelPortaliA5PKW4.
SMRiA5PKW4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111641. 2 interactors.
IntActiA5PKW4. 12 interactors.
MINTiMINT-7897159.
STRINGi9606.ENSP00000020673.

PTM databases

iPTMnetiA5PKW4.
PhosphoSitePlusiA5PKW4.

Proteomic databases

PaxDbiA5PKW4.
PRIDEiA5PKW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000020673; ENSP00000020673; ENSG00000059915. [A5PKW4-1]
ENST00000406432; ENSP00000384830; ENSG00000059915. [A5PKW4-1]
ENST00000611678; ENSP00000481250; ENSG00000059915. [A5PKW4-2]
GeneIDi5662.
KEGGihsa:5662.
UCSCiuc001kvg.3. human. [A5PKW4-1]

Organism-specific databases

CTDi5662.
DisGeNETi5662.
GeneCardsiPSD.
H-InvDBHIX0025909.
HGNCiHGNC:9507. PSD.
HPAiHPA059237.
MIMi602327. gene.
neXtProtiNX_A5PKW4.
OpenTargetsiENSG00000059915.
PharmGKBiPA33854.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00860000133718.
HOGENOMiHOG000060162.
HOVERGENiHBG106661.
InParanoidiA5PKW4.
KOiK12494.
OMAiDAPWTER.
OrthoDBiEOG091G0187.
PhylomeDBiA5PKW4.
TreeFamiTF319755.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173692-MONOMER.

Miscellaneous databases

ChiTaRSiPSD. human.
GenomeRNAii5662.
PROiA5PKW4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000059915.
CleanExiHS_PSD.
GenevisibleiA5PKW4. HS.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSD1_HUMAN
AccessioniPrimary (citable) accession number: A5PKW4
Secondary accession number(s): B1AKX7
, D3DR87, Q15673, Q8IVG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.