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A5PKH3 (FAAA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fumarylacetoacetase
Short name=FAA
EC=3.7.1.2
Alternative name(s):
Beta-diketonase
Fumarylacetoacetate hydrolase
Gene names
Name:FAH
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

4-fumarylacetoacetate + H2O = acetoacetate + fumarate.

Cofactor

Calcium By similarity.

Magnesium By similarity.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the FAH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 419418Fumarylacetoacetase
PRO_0000318804

Sites

Active site1331Proton acceptor Probable
Metal binding1261Calcium By similarity
Metal binding1991Calcium By similarity
Metal binding2011Calcium By similarity
Metal binding2331Calcium By similarity
Metal binding2331Magnesium By similarity
Metal binding2531Magnesium By similarity
Metal binding2571Magnesium By similarity
Binding site1281Substrate By similarity
Binding site1421Substrate By similarity
Binding site2401Substrate By similarity
Binding site2441Substrate By similarity
Binding site3501Substrate By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity

Experimental info

Sequence conflict3321H → D in AAI51491. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A5PKH3 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 801EA75E57B729DD

FASTA41946,156
        10         20         30         40         50         60 
MSFVPVAEDS DFPIHNLPYG VFSTRGNPRP RIGVAIGDQI LDLSVIKHLF TGPILSGHQD 

        70         80         90        100        110        120 
VFNKPTLNSF MGLGQAAWKE ARAFLQNLLS ASQARLRDDV ELRQRAFTSQ ASATMYLPAT 

       130        140        150        160        170        180 
IGDYTDFYSS RHHATNVGVM FRGKENALMP NWLHLPVGYH GRASSVVVSG TPIRRPLGQM 

       190        200        210        220        230        240 
RPDDSKPPVY GACKLLDFEL EMAFFVGPGN KLGEPIPISK AHEHIFGMVL MNDWSARDIQ 

       250        260        270        280        290        300 
KWEYVPLGPF LGKSFGTTIS PWVVPMDALM PFAVSNPEQD PKPLPYLCHD QPYTFDINLS 

       310        320        330        340        350        360 
VALKGEGMSQ AATICRSNFK YMYWTMLQQL THHSVNGCNL QPGDLLASGT ISGPEPESFG 

       370        380        390        400        410 
CMLELSWKGT RAVELGNGQT RKFLLDGDEV IMTGHCQGDG YRIGFGQCAG KVLPALSFA

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Ascending colon, Fetal liver and Fetal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC142487 mRNA. Translation: AAI42488.1.
BC151490 mRNA. Translation: AAI51491.1.
BC151824 mRNA. Translation: AAI51825.1.
IPIIPI00705822.
RefSeqNP_001092382.1. NM_001098912.1.
UniGeneBt.16412.

3D structure databases

ProteinModelPortalA5PKH3.
SMRA5PKH3. Positions 1-417.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5PKH3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID508724.
KEGGbta:508724.

Organism-specific databases

CTD2184.

Phylogenomic databases

GeneTreeENSGT00390000008646.
HOVERGENHBG001919.
InParanoidA5PKH3.
OrthoDBEOG4Q2DFM.

Family and domain databases

InterProIPR005959. Fumarylacetoacetase.
IPR002529. Fumarylacetoacetase_C.
IPR011234. Fumarylacetoacetase_C-rel.
IPR015377. Fumarylacetoacetase_N.
[Graphical view]
Gene3DG3DSA:3.90.850.10. Fumarylacetoacetase_C-rel. 1 hit.
G3DSA:2.30.30.230. Fumarylacetoacetase_N. 1 hit.
KOK01555.
PANTHERPTHR11820:SF1. Fum_ac_acetase. 1 hit.
PfamPF09298. DUF1969. 1 hit.
PF01557. FAA_hydrolase. 1 hit.
[Graphical view]
SUPFAMSSF56529. Fumarylacetoacetase_C-rel. 1 hit.
SSF63433. Fumarylacetoacetase_N. 1 hit.
TIGRFAMsTIGR01266. Fum_ac_acetase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFAAA_BOVIN
AccessionPrimary (citable) accession number: A5PKH3
Secondary accession number(s): A7MBC9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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