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Protein

Insulin-like growth factor-binding protein-like 1

Gene

IGFBPL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein-like 1
Gene namesi
Name:IGFBPL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:30090 IGFBPL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029768622 – 274Insulin-like growth factor-binding protein-like 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi111 ↔ 147PROSITE-ProRule annotation
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi172 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5PKD8
PRIDEiA5PKD8

Expressioni

Gene expression databases

BgeeiENSBTAG00000014078

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018719

Structurei

3D structure databases

ProteinModelPortaliA5PKD8
SMRiA5PKD8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini91 – 149Kazal-likePROSITE-ProRule annotationAdd BLAST59
Domaini151 – 255Ig-like C2-typeAdd BLAST105

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IJPX Eukaryota
ENOG4111QG6 LUCA
GeneTreeiENSGT00530000063555
HOGENOMiHOG000261684
HOVERGENiHBG031621
InParanoidiA5PKD8
OMAiRDECGCC
OrthoDBiEOG091G0QK5
TreeFamiTF331645

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR000867 IGFBP-like
IPR011390 IGFBP_rP_mac25
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
PANTHERiPTHR14186 PTHR14186, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00219 IGFBP, 1 hit
PF07648 Kazal_2, 1 hit
PIRSFiPIRSF018239 IGFBP_rP_mac25, 1 hit
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF48726 SSF48726, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS51465 KAZAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PKD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSPGLFLL LLVLQPLPAL GLGLRSAGGR NPECGPCRPE RCPEPVRCPV
60 70 80 90 100
PGIVARDECG CCALCLGAEG ASCGGRAGAR CGPGLVCASR AAGAAPEGTG
110 120 130 140 150
LCVCAQRGSV CGSDGRSYPS VCALRLRARQ APRALPGHLH KARDGPCEFA
160 170 180 190 200
PVVITPPQSV HNVTGAQVYL SCEVRAVPTP VVTWRKVTRS PEGTQVMEEL
210 220 230 240 250
PGDHTNIAVQ VQGGPSDHEA TAWVLINPLR KEDEGVYQCH SANAVGEAQS
260 270
HGTVTVVDRS QYRAPRFPAP DDRL
Length:274
Mass (Da):28,673
Last modified:July 10, 2007 - v1
Checksum:iB7046C22C270F397
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142451 mRNA Translation: AAI42452.1
RefSeqiNP_001092631.1, NM_001099161.2
UniGeneiBt.32572

Genome annotation databases

EnsembliENSBTAT00000018719; ENSBTAP00000018719; ENSBTAG00000014078
GeneIDi616886
KEGGibta:616886

Similar proteinsi

Entry informationi

Entry nameiIBPL1_BOVIN
AccessioniPrimary (citable) accession number: A5PKD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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