Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor-binding protein-like 1

Gene

IGFBPL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs in cell culture. They alter the interaction of IGFs with their cell surface receptors (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein-like 1
Gene namesi
Name:IGFBPL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029768622 – 274Insulin-like growth factor-binding protein-like 1Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi172 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5PKD8.
PRIDEiA5PKD8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000014078.

Structurei

3D structure databases

ProteinModelPortaliA5PKD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini91 – 149Kazal-likePROSITE-ProRule annotationAdd BLAST59
Domaini151 – 255Ig-like C2-typeAdd BLAST105

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IJPX. Eukaryota.
ENOG4111QG6. LUCA.
GeneTreeiENSGT00530000063555.
HOGENOMiHOG000261684.
HOVERGENiHBG031621.
InParanoidiA5PKD8.
OMAiRDECGCC.
OrthoDBiEOG091G0QK5.
TreeFamiTF331645.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PKD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSPGLFLL LLVLQPLPAL GLGLRSAGGR NPECGPCRPE RCPEPVRCPV
60 70 80 90 100
PGIVARDECG CCALCLGAEG ASCGGRAGAR CGPGLVCASR AAGAAPEGTG
110 120 130 140 150
LCVCAQRGSV CGSDGRSYPS VCALRLRARQ APRALPGHLH KARDGPCEFA
160 170 180 190 200
PVVITPPQSV HNVTGAQVYL SCEVRAVPTP VVTWRKVTRS PEGTQVMEEL
210 220 230 240 250
PGDHTNIAVQ VQGGPSDHEA TAWVLINPLR KEDEGVYQCH SANAVGEAQS
260 270
HGTVTVVDRS QYRAPRFPAP DDRL
Length:274
Mass (Da):28,673
Last modified:July 10, 2007 - v1
Checksum:iB7046C22C270F397
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142451 mRNA. Translation: AAI42452.1.
RefSeqiNP_001092631.1. NM_001099161.2.
UniGeneiBt.32572.

Genome annotation databases

EnsembliENSBTAT00000018719; ENSBTAP00000018719; ENSBTAG00000014078.
GeneIDi616886.
KEGGibta:616886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142451 mRNA. Translation: AAI42452.1.
RefSeqiNP_001092631.1. NM_001099161.2.
UniGeneiBt.32572.

3D structure databases

ProteinModelPortaliA5PKD8.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiA5PKD8.
PRIDEiA5PKD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018719; ENSBTAP00000018719; ENSBTAG00000014078.
GeneIDi616886.
KEGGibta:616886.

Organism-specific databases

CTDi347252.

Phylogenomic databases

eggNOGiENOG410IJPX. Eukaryota.
ENOG4111QG6. LUCA.
GeneTreeiENSGT00530000063555.
HOGENOMiHOG000261684.
HOVERGENiHBG031621.
InParanoidiA5PKD8.
OMAiRDECGCC.
OrthoDBiEOG091G0QK5.
TreeFamiTF331645.

Gene expression databases

BgeeiENSBTAG00000014078.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR000867. IGFBP-like.
IPR011390. IGFBP_rP_mac25.
IPR002350. Kazal_dom.
[Graphical view]
PANTHERiPTHR14186. PTHR14186. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF00219. IGFBP. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
PIRSFiPIRSF018239. IGFBP_rP_mac25. 1 hit.
SMARTiSM00121. IB. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBPL1_BOVIN
AccessioniPrimary (citable) accession number: A5PKD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.