A5PK65 (DOPD_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-dopachrome decarboxylase
EC=4.1.1.84

Alternative name(s):
D-dopachrome tautomerase

Gene names

Name:

DDT

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) By similarity.
Catalytic activity	D-dopachrome = 5,6-dihydroxyindole + CO2.
Subunit structure	Homotrimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Melanin biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	melanin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-dopachrome decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 118	117	D-dopachrome decarboxylase		PRO_0000337233
Amino acid modifications
	Modified residue	2	1	N-acetylproline By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5PK65 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 15C8E564BCBB8DD7	FASTA	118	12,877
	10 20 30 40 50 60 MPFVELDTSL PAGRVPAGLE KRLCAATAAI LSKPEDRVNV TVRSGLAMVV NGSAEPSAQL 70 80 90 100 110 LVSSIGVVGT AEENRGHSAR FFEFLTKELD LAEDRIMIRF FPLERWQIGK KGTVMTFL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC142376 mRNA. Translation: AAI42377.1.
IPI	IPI00709665.
RefSeq	NP_001092620.1. NM_001099150.1.
UniGene	Bt.35699.
3D structure databases
ProteinModelPortal	A5PK65.
SMR	A5PK65. Positions 2-118.
ModBase	Search...
Proteomic databases
PRIDE	A5PK65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000029458; ENSBTAP00000029458; ENSBTAG00000022027.
GeneID	615999.
KEGG	bta:615999.
Organism-specific databases
CTD	1652.
Phylogenomic databases
eggNOG	maNOG20462.
GeneTree	ENSGT00530000063544.
HOVERGEN	HBG003240.
InParanoid	A5PK65.
OMA	SMGKPRE.
OrthoDB	EOG46T330.
PhylomeDB	A5PK65.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR014347. Tautomerase. [Graphical view]
Gene3D	G3DSA:3.30.429.10. Tautomerase. 1 hit.
KO	K10028.
PANTHER	PTHR11954. MIF. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. Macrophage_inhib_fac. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF55331. SSF55331. 1 hit.
PROSITE	PS01158. MIF. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DOPD_BOVIN

Accession

Primary (citable) accession number: A5PK65

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program