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A5PK51

- PNCB_BOVIN

UniProt

A5PK51 - PNCB_BOVIN

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Protein

Nicotinate phosphoribosyltransferase

Gene

NAPRT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.By similarity
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Alternative name(s):
Nicotinate phosphoribosyltransferase domain-containing protein 1
Gene namesi
Name:NAPRT
Synonyms:NAPRT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Nicotinate phosphoribosyltransferasePRO_0000315680Add
BLAST

Proteomic databases

PRIDEiA5PK51.

Structurei

3D structure databases

ProteinModelPortaliA5PK51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.Curated

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000001111.
HOVERGENiHBG062439.
InParanoidiA5PK51.
KOiK00763.

Family and domain databases

InterProiIPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 2 hits.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 2 hits.
TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A5PK51-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEQDPEGR AAARPLLTDL YQATMALGYW RAGRAQDQAE FELFFRQCPF
60 70 80 90 100
GGAFALAAGL RDCVRFLRAF RLRDADVQFL ASALPPDTDP AFFEHLRALD
110 120 130 140 150
CSGVTVRALP EGSLAFPGVP LLQVSGPLLV VQLLETPLLC LVSYASLIAT
160 170 180 190 200
NAARLRLIAG PDKRLLEMGL RRAQGPDGGL TASTYSYLGG FDASSNVLAG
210 220 230 240 250
QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APAAGQGSQV DLAASVEMWL
260 270 280 290 300
ERVCGHLGLG VQEPHRGERA AFVAYALAFP RAFQGLLDTY SVRRSGLPNF
310 320 330 340 350
LAVALALQEL GYQAVGVRLD SGDLLQQARE IRGVFRTAAA QFGVPWLQSV
360 370 380 390 400
PIAVSNNIDE EELARLAQKG SEVNVIGIGT SVVTCPRQPS LGCVYKLVSV
410 420 430 440 450
GGQPRMKLTE DPEKQTLPGS KAAFRLLGSD GSLLLDVLQL AEEPPPQAGQ
460 470 480 490 500
ELRVWPRGAR ESRTVRPAHV EPLLRLWVQQ GQLCEPLPSL AESRAFAQQS
510 520 530
LHRLSPAHRR LEQPALYQVA LSEKLQALVD RLSARGAL
Length:538
Mass (Da):57,871
Last modified:January 15, 2008 - v2
Checksum:iCDE2E6FF34A613A9
GO
Isoform 2 (identifier: A5PK51-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-435: Missing.

Note: No experimental confirmation available.

Show »
Length:533
Mass (Da):57,388
Checksum:i1DE470E605E4D07F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581A → E in AAP69606. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei431 – 4355Missing in isoform 2. 1 PublicationVSP_030609

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142357 mRNA. Translation: AAI42358.1.
AY214328 mRNA. Translation: AAP69606.1.
RefSeqiNP_001092327.1. NM_001098857.2. [A5PK51-2]
UniGeneiBt.23360.

Genome annotation databases

GeneIDi399559.
KEGGibta:399559.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142357 mRNA. Translation: AAI42358.1 .
AY214328 mRNA. Translation: AAP69606.1 .
RefSeqi NP_001092327.1. NM_001098857.2. [A5PK51-2 ]
UniGenei Bt.23360.

3D structure databases

ProteinModelPortali A5PK51.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A5PK51.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399559.
KEGGi bta:399559.

Organism-specific databases

CTDi 315085.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000001111.
HOVERGENi HBG062439.
InParanoidi A5PK51.
KOi K00763.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Miscellaneous databases

NextBioi 20816605.

Family and domain databases

InterProi IPR007229. Nic_PRibTrfase-Fam.
IPR006405. Nic_PRibTrfase_pncB.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 2 hits.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 2 hits.
TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
    Huang C.-H., Peng J., Chen Y.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-538 (ISOFORM 1).

Entry informationi

Entry nameiPNCB_BOVIN
AccessioniPrimary (citable) accession number: A5PK51
Secondary accession number(s): Q6XQN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 29, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3