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A5PK51

- PNCB_BOVIN

UniProt

A5PK51 - PNCB_BOVIN

Protein

Nicotinate phosphoribosyltransferase

Gene

NAPRT

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells By similarity.By similarity
    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.By similarity

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide salvage Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
    Short name:
    NAPRTase
    Alternative name(s):
    Nicotinate phosphoribosyltransferase domain-containing protein 1
    Gene namesi
    Name:NAPRT
    Synonyms:NAPRT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Nicotinate phosphoribosyltransferasePRO_0000315680Add
    BLAST

    Proteomic databases

    PRIDEiA5PK51.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PK51.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.Curated

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000001111.
    HOVERGENiHBG062439.
    InParanoidiA5PK51.
    KOiK00763.

    Family and domain databases

    InterProiIPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 2 hits.
    TIGRFAMsiTIGR01513. NAPRTase_put. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A5PK51-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEQDPEGR AAARPLLTDL YQATMALGYW RAGRAQDQAE FELFFRQCPF    50
    GGAFALAAGL RDCVRFLRAF RLRDADVQFL ASALPPDTDP AFFEHLRALD 100
    CSGVTVRALP EGSLAFPGVP LLQVSGPLLV VQLLETPLLC LVSYASLIAT 150
    NAARLRLIAG PDKRLLEMGL RRAQGPDGGL TASTYSYLGG FDASSNVLAG 200
    QLRGVPVAGT LAHSFVTSFS GSEVPPDPML APAAGQGSQV DLAASVEMWL 250
    ERVCGHLGLG VQEPHRGERA AFVAYALAFP RAFQGLLDTY SVRRSGLPNF 300
    LAVALALQEL GYQAVGVRLD SGDLLQQARE IRGVFRTAAA QFGVPWLQSV 350
    PIAVSNNIDE EELARLAQKG SEVNVIGIGT SVVTCPRQPS LGCVYKLVSV 400
    GGQPRMKLTE DPEKQTLPGS KAAFRLLGSD GSLLLDVLQL AEEPPPQAGQ 450
    ELRVWPRGAR ESRTVRPAHV EPLLRLWVQQ GQLCEPLPSL AESRAFAQQS 500
    LHRLSPAHRR LEQPALYQVA LSEKLQALVD RLSARGAL 538
    Length:538
    Mass (Da):57,871
    Last modified:January 15, 2008 - v2
    Checksum:iCDE2E6FF34A613A9
    GO
    Isoform 2 (identifier: A5PK51-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         431-435: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:533
    Mass (Da):57,388
    Checksum:i1DE470E605E4D07F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581A → E in AAP69606. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei431 – 4355Missing in isoform 2. 1 PublicationVSP_030609

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142357 mRNA. Translation: AAI42358.1.
    AY214328 mRNA. Translation: AAP69606.1.
    RefSeqiNP_001092327.1. NM_001098857.2. [A5PK51-2]
    UniGeneiBt.23360.

    Genome annotation databases

    GeneIDi399559.
    KEGGibta:399559.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142357 mRNA. Translation: AAI42358.1 .
    AY214328 mRNA. Translation: AAP69606.1 .
    RefSeqi NP_001092327.1. NM_001098857.2. [A5PK51-2 ]
    UniGenei Bt.23360.

    3D structure databases

    ProteinModelPortali A5PK51.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A5PK51.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399559.
    KEGGi bta:399559.

    Organism-specific databases

    CTDi 223646.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000001111.
    HOVERGENi HBG062439.
    InParanoidi A5PK51.
    KOi K00763.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .

    Miscellaneous databases

    NextBioi 20816605.

    Family and domain databases

    InterProi IPR007229. Nic_PRibTrfase-Fam.
    IPR006405. Nic_PRibTrfase_pncB.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 2 hits.
    TIGRFAMsi TIGR01513. NAPRTase_put. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Crossbred X Angus.
      Tissue: Ileum.
    2. "Sequence analysis and molecular evolution of the eukaryotic nicotinate phosphoribosyltransferase family."
      Huang C.-H., Peng J., Chen Y.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-538 (ISOFORM 1).

    Entry informationi

    Entry nameiPNCB_BOVIN
    AccessioniPrimary (citable) accession number: A5PK51
    Secondary accession number(s): Q6XQN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3