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Protein

Pancreatic lipase-related protein 2

Gene

PNLIPRP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity).By similarity

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.
1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates.

Enzyme regulationi

CLPS stimulates triacylglycerol lipase activity. Triacylglycerol lipase activity is not inhibited by increasing bile salt concentration.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171NucleophileBy similarity1
Active sitei195Charge relay systemPROSITE-ProRule annotation1
Metal bindingi206Calcium; via carbonyl oxygenBy similarity1
Metal bindingi209Calcium; via carbonyl oxygenBy similarity1
Metal bindingi211CalciumBy similarity1
Metal bindingi214CalciumBy similarity1
Active sitei282Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Protein family/group databases

ESTHERibovin-lipr2 Pancreatic_lipase

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic lipase-related protein 2By similarity (EC:3.1.1.26, EC:3.1.1.3)
Short name:
PL-RP2By similarity
Alternative name(s):
Galactolipase
Gene namesi
Name:PNLIPRP2By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000035514318 – 469Pancreatic lipase-related protein 2Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 27PROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 120PROSITE-ProRule annotation
Disulfide bondi256 ↔ 280PROSITE-ProRule annotation
Disulfide bondi304 ↔ 315PROSITE-ProRule annotation
Disulfide bondi318 ↔ 323PROSITE-ProRule annotation
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi453 ↔ 469PROSITE-ProRule annotation
Glycosylationi455N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

SMRiA5PK46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini357 – 469PLATPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000038552
HOVERGENiHBG003243
InParanoidiA5PK46
KOiK14075

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002331 Lipase_panc
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00823 PANCLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PK46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSWTIGLL LLATVRGKEI CYEPFGCFSD EKPWTGILQR PLKLFPWSPE
60 70 80 90 100
DIDAHFLLYT NENPNNYQRI NITDLATVRA SNFQLDRKTR FVIHGFIDDG
110 120 130 140 150
DSGWPTDLCK KMFKVEKVNC ICVDWEHGAW TKYTQAVHNT RVVGAEIAFF
160 170 180 190 200
IQGLSTELGY GPENVHLIGH SLGAQLAAEA GRRLGGQVGR ITGLDPAQPC
210 220 230 240 250
FEGTPEEVRL DPSDAMFVDV IHTDSASIIP FLSLGIRQKV GHLDFYPNGG
260 270 280 290 300
KEMPGCQKNI LSTIIDINGI WQGIQDFVAC SHLRSYKYYS SSILNPDGFL
310 320 330 340 350
GYPCASYEEF QEGGCFPCPA GGCPKMGHYA DQFQGKTSAV GQTFFLNTGS
360 370 380 390 400
SGNFTSWRYR VSVTLAGTKK VRGSIRIALY GSNGNSKQYQ IFKGSLQPNA
410 420 430 440 450
SHTHDIDVDL NVGKVQKVKF LWNNNVINLF WPKLGASRVT VQGGEDRTEY
460
NFCSNDTMRE NALQTLYPC
Length:469
Mass (Da):52,193
Last modified:July 10, 2007 - v1
Checksum:i9B4BD4A17CCCA121
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142351 mRNA Translation: AAI42352.1
RefSeqiNP_001098825.1, NM_001105355.2
UniGeneiBt.25452

Genome annotation databases

GeneIDi510772
KEGGibta:510772

Similar proteinsi

Entry informationi

Entry nameiLIPR2_BOVIN
AccessioniPrimary (citable) accession number: A5PK46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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