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A5PK45

- GT251_BOVIN

UniProt

A5PK45 - GT251_BOVIN

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Protein
Procollagen galactosyltransferase 1
Gene
COLGALT1, GLT25D1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen By similarity.

Catalytic activityi

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

GO - Molecular functioni

  1. procollagen galactosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_215758. Collagen biosynthesis and modifying enzymes.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen galactosyltransferase 1 (EC:2.4.1.50)
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1
Glycosyltransferase 25 family member 1
Hydroxylysine galactosyltransferase 1
Gene namesi
Name:COLGALT1
Synonyms:GLT25D1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Endoplasmic reticulum lumen By similarity
Note: Colocalized with PLOD3 and mannose binding lectin By similarity.

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 623593Procollagen galactosyltransferase 1
PRO_0000309535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi185 – 1851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi382 – 3821N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA5PK45.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016841.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi620 – 6234Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
GeneTreeiENSGT00550000074427.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA5PK45.
KOiK11703.
OMAiMWADYIL.
OrthoDBiEOG7060RC.
TreeFamiTF313826.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PK45-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAPRACKG HGRPLPVLLL LLLLALPPLG GPPGAAAYFP EERWSPESPL    50
QAPRVLIALL ARNAAHALPA TLGALERLRH PRERTALWVA TDHNADNTSA 100
VLREWLVAVK GLYHSVEWRP SEEPRSYPDE EGPKHWSDSR YEHVMKLRQA 150
ALKSARDMWA DYILFVDADN LILNPDTLTL LIAENKTVVA PMLDSRAAYS 200
NFWCGMTSQG YYKRTPAYIP IRKRERRGCF AVPMVHSTFL IDLRKAASRN 250
LAFYPPHPDY TWSFDDIIVF AFSCKQAEVQ MYVCNKEVYG FLPVPLRSHS 300
TLQDEAESFM HVQLEVMVKH PPSEPSRFIS VPTKTPDKMG FDEVFMINLK 350
RRQDRRERML RALEEQEIAC RLVEAVDGKA MNTSQVEALG IQMLPGYRDP 400
YHGRPLTKGE LGCFLSHYNI WKEVVDRGLQ KSLVFEDDLR FEIFFKRRLM 450
NLMQDVEREG LDWDLIYVGR KRMQVEHPEK AVPRVRNLVE ADYSYWTLAY 500
VISLQGARKL LAARPLSKML PVDEFLPVMF DKHPVSEYKA HFSPRDLRAF 550
SVEPLLIYPT HYTGDDGYVS DTETSVVWNN EHVKTDWDRA KSQKMREQQA 600
LSREAKNSDV LQSPLDSAAR DEL 623
Length:623
Mass (Da):71,547
Last modified:July 10, 2007 - v1
Checksum:i8DE0E6A8A66A8384
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142350 mRNA. Translation: AAI42351.1.
RefSeqiNP_001092425.1. NM_001098955.1.
UniGeneiBt.29548.

Genome annotation databases

EnsembliENSBTAT00000016841; ENSBTAP00000016841; ENSBTAG00000012678.
GeneIDi513167.
KEGGibta:513167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142350 mRNA. Translation: AAI42351.1 .
RefSeqi NP_001092425.1. NM_001098955.1.
UniGenei Bt.29548.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000016841.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEi A5PK45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000016841 ; ENSBTAP00000016841 ; ENSBTAG00000012678 .
GeneIDi 513167.
KEGGi bta:513167.

Organism-specific databases

CTDi 79709.

Phylogenomic databases

eggNOGi COG3306.
GeneTreei ENSGT00550000074427.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi A5PK45.
KOi K11703.
OMAi MWADYIL.
OrthoDBi EOG7060RC.
TreeFami TF313826.

Enzyme and pathway databases

Reactomei REACT_215758. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 20870734.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pancreas.

Entry informationi

Entry nameiGT251_BOVIN
AccessioniPrimary (citable) accession number: A5PK45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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