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A5PK45

- GT251_BOVIN

UniProt

A5PK45 - GT251_BOVIN

Protein

Procollagen galactosyltransferase 1

Gene

COLGALT1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen.By similarity

    Catalytic activityi

    UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

    GO - Molecular functioni

    1. procollagen galactosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipopolysaccharide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215758. Collagen biosynthesis and modifying enzymes.

    Protein family/group databases

    CAZyiGT25. Glycosyltransferase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Procollagen galactosyltransferase 1 (EC:2.4.1.50)
    Alternative name(s):
    Collagen beta(1-O)galactosyltransferase 1
    Glycosyltransferase 25 family member 1
    Hydroxylysine galactosyltransferase 1
    Gene namesi
    Name:COLGALT1
    Synonyms:GLT25D1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation
    Note: Colocalized with PLOD3 and mannose binding lectin.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 623593Procollagen galactosyltransferase 1PRO_0000309535Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiA5PK45.

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000016841.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi620 – 6234Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the glycosyltransferase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3306.
    GeneTreeiENSGT00550000074427.
    HOGENOMiHOG000007198.
    HOVERGENiHBG058097.
    InParanoidiA5PK45.
    KOiK11703.
    OMAiMWADYIL.
    OrthoDBiEOG7060RC.
    TreeFamiTF313826.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF01755. Glyco_transf_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5PK45-1 [UniParc]FASTAAdd to Basket

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    MAAAPRACKG HGRPLPVLLL LLLLALPPLG GPPGAAAYFP EERWSPESPL    50
    QAPRVLIALL ARNAAHALPA TLGALERLRH PRERTALWVA TDHNADNTSA 100
    VLREWLVAVK GLYHSVEWRP SEEPRSYPDE EGPKHWSDSR YEHVMKLRQA 150
    ALKSARDMWA DYILFVDADN LILNPDTLTL LIAENKTVVA PMLDSRAAYS 200
    NFWCGMTSQG YYKRTPAYIP IRKRERRGCF AVPMVHSTFL IDLRKAASRN 250
    LAFYPPHPDY TWSFDDIIVF AFSCKQAEVQ MYVCNKEVYG FLPVPLRSHS 300
    TLQDEAESFM HVQLEVMVKH PPSEPSRFIS VPTKTPDKMG FDEVFMINLK 350
    RRQDRRERML RALEEQEIAC RLVEAVDGKA MNTSQVEALG IQMLPGYRDP 400
    YHGRPLTKGE LGCFLSHYNI WKEVVDRGLQ KSLVFEDDLR FEIFFKRRLM 450
    NLMQDVEREG LDWDLIYVGR KRMQVEHPEK AVPRVRNLVE ADYSYWTLAY 500
    VISLQGARKL LAARPLSKML PVDEFLPVMF DKHPVSEYKA HFSPRDLRAF 550
    SVEPLLIYPT HYTGDDGYVS DTETSVVWNN EHVKTDWDRA KSQKMREQQA 600
    LSREAKNSDV LQSPLDSAAR DEL 623
    Length:623
    Mass (Da):71,547
    Last modified:July 10, 2007 - v1
    Checksum:i8DE0E6A8A66A8384
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142350 mRNA. Translation: AAI42351.1.
    RefSeqiNP_001092425.1. NM_001098955.1.
    UniGeneiBt.29548.

    Genome annotation databases

    EnsembliENSBTAT00000016841; ENSBTAP00000016841; ENSBTAG00000012678.
    GeneIDi513167.
    KEGGibta:513167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142350 mRNA. Translation: AAI42351.1 .
    RefSeqi NP_001092425.1. NM_001098955.1.
    UniGenei Bt.29548.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000016841.

    Protein family/group databases

    CAZyi GT25. Glycosyltransferase Family 25.

    Proteomic databases

    PRIDEi A5PK45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016841 ; ENSBTAP00000016841 ; ENSBTAG00000012678 .
    GeneIDi 513167.
    KEGGi bta:513167.

    Organism-specific databases

    CTDi 79709.

    Phylogenomic databases

    eggNOGi COG3306.
    GeneTreei ENSGT00550000074427.
    HOGENOMi HOG000007198.
    HOVERGENi HBG058097.
    InParanoidi A5PK45.
    KOi K11703.
    OMAi MWADYIL.
    OrthoDBi EOG7060RC.
    TreeFami TF313826.

    Enzyme and pathway databases

    Reactomei REACT_215758. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 20870734.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR002654. Glyco_trans_25.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF01755. Glyco_transf_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal pancreas.

    Entry informationi

    Entry nameiGT251_BOVIN
    AccessioniPrimary (citable) accession number: A5PK45
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3