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A5PK45 (GT251_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Procollagen galactosyltransferase 1

EC=2.4.1.50
Alternative name(s):
Collagen beta(1-O)galactosyltransferase 1
Glycosyltransferase 25 family member 1
Hydroxylysine galactosyltransferase 1
Gene names
Name:COLGALT1
Synonyms:GLT25D1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length623 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues of collagen By similarity.

Catalytic activity

UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen].

Subcellular location

Endoplasmic reticulum lumen By similarity. Note: Colocalized with PLOD3 and mannose binding lectin By similarity.

Post-translational modification

N-glycosylated By similarity.

Sequence similarities

Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionprocollagen galactosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 623593Procollagen galactosyltransferase 1
PRO_0000309535

Regions

Motif620 – 6234Prevents secretion from ER By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation3821N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A5PK45 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 8DE0E6A8A66A8384

FASTA62371,547
        10         20         30         40         50         60 
MAAAPRACKG HGRPLPVLLL LLLLALPPLG GPPGAAAYFP EERWSPESPL QAPRVLIALL 

        70         80         90        100        110        120 
ARNAAHALPA TLGALERLRH PRERTALWVA TDHNADNTSA VLREWLVAVK GLYHSVEWRP 

       130        140        150        160        170        180 
SEEPRSYPDE EGPKHWSDSR YEHVMKLRQA ALKSARDMWA DYILFVDADN LILNPDTLTL 

       190        200        210        220        230        240 
LIAENKTVVA PMLDSRAAYS NFWCGMTSQG YYKRTPAYIP IRKRERRGCF AVPMVHSTFL 

       250        260        270        280        290        300 
IDLRKAASRN LAFYPPHPDY TWSFDDIIVF AFSCKQAEVQ MYVCNKEVYG FLPVPLRSHS 

       310        320        330        340        350        360 
TLQDEAESFM HVQLEVMVKH PPSEPSRFIS VPTKTPDKMG FDEVFMINLK RRQDRRERML 

       370        380        390        400        410        420 
RALEEQEIAC RLVEAVDGKA MNTSQVEALG IQMLPGYRDP YHGRPLTKGE LGCFLSHYNI 

       430        440        450        460        470        480 
WKEVVDRGLQ KSLVFEDDLR FEIFFKRRLM NLMQDVEREG LDWDLIYVGR KRMQVEHPEK 

       490        500        510        520        530        540 
AVPRVRNLVE ADYSYWTLAY VISLQGARKL LAARPLSKML PVDEFLPVMF DKHPVSEYKA 

       550        560        570        580        590        600 
HFSPRDLRAF SVEPLLIYPT HYTGDDGYVS DTETSVVWNN EHVKTDWDRA KSQKMREQQA 

       610        620 
LSREAKNSDV LQSPLDSAAR DEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC142350 mRNA. Translation: AAI42351.1.
RefSeqNP_001092425.1. NM_001098955.1.
UniGeneBt.29548.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000016841.

Protein family/group databases

CAZyGT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEA5PK45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016841; ENSBTAP00000016841; ENSBTAG00000012678.
GeneID513167.
KEGGbta:513167.

Organism-specific databases

CTD79709.

Phylogenomic databases

eggNOGCOG3306.
GeneTreeENSGT00550000074427.
HOGENOMHOG000007198.
HOVERGENHBG058097.
InParanoidA5PK45.
KOK11703.
OMAMWADYIL.
OrthoDBEOG7060RC.
TreeFamTF313826.

Family and domain databases

InterProIPR002654. Glyco_trans_25.
[Graphical view]
PfamPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870734.

Entry information

Entry nameGT251_BOVIN
AccessionPrimary (citable) accession number: A5PK45
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families