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A5PK16

- CCNF_BOVIN

UniProt

A5PK16 - CCNF_BOVIN

Protein

Cyclin-F

Gene

CCNF

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of centrosome duplication Source: UniProtKB
    3. placenta development Source: Ensembl
    4. protein ubiquitination Source: UniProtKB
    5. re-entry into mitotic cell cycle Source: Ensembl
    6. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-F
    Gene namesi
    Name:CCNF
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 25

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
    Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 788788Cyclin-FPRO_0000398634Add
    BLAST

    Post-translational modificationi

    Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence By similarity.By similarity
    Phosphorylated just before cells enter into mitosis.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000034530.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PK16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 7648F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini294 – 405112Cyclin N-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni582 – 766185PESTAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi20 – 289Nuclear localization signal 1By similarity
    Motifi568 – 5747Nuclear localization signal 2By similarity

    Domaini

    The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283043.
    HOGENOMiHOG000285971.
    HOVERGENiHBG050838.
    InParanoidiA5PK16.
    KOiK10289.
    OMAiKSCLQCR.
    OrthoDBiEOG7WDN1V.
    TreeFamiTF101006.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProiIPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5PK16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSGGVIHCR CAKCFCYPSK RRIRRRPRNL TILNLPEDAL FHILKWLSVG    50
    DILAVRAVHS HLKYLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF 100
    EAAVKLGIAY LYNEGLSVSD EARAEVNGLR ASRYFSLAER LNVGAAPFIW 150
    LFIRPPWSVS GSCCKAVVHE SLRAECQLQK THRASILHCL GRVLSLFEDE 200
    EKQKQARKLF EESANQGCLT SSYLLWESDR RMDMLDPGRC LHSFRKLRDF 250
    AAKGCWEAQL SLAKACAHGH QLGLEAKASS EIVCQLFQAS HAVNKQRVFS 300
    VQKGLNDTMR YILIDWLVEV ATMKDFSSLC LHLTVECVDR YLRRRLVPRY 350
    RLQLLGIACM VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEVVSA 400
    LDGKIRVPTV VDYKDVLLTL VPMAPRTQHL CSFLCELSLL HTSLAAYAPA 450
    HLAAAALLLA RLTHGQTQPW TTQLWDLTGF SCEDLIPCVL SLHQKCFHDD 500
    APKDYRQVSL TAVKQRFEDK RYEEISLEEV LSYGQLCAAL GVKQESLEPA 550
    PFLSAGDIHA FLSSPSARRT KRKRENSLQE DRGSFVTTPT AELSSQEETL 600
    LGSFLDWSLD YCSGYEGDQE SEGEKEGDVT APSGVLDVTV VYLSPEEHCC 650
    QESSDEEACP EEACGAQDTQ ALVPGHQALR TPGPEPPLCS RWGLGKDVTT 700
    SGYSSVNSAS PTDSGRTSGG PPRSTSELPT GSSLNTQPCH HHARKSCLQC 750
    RPPSPPESCA PQQQVKRKNL SAHSEEEEED MNLGFLKL 788
    Length:788
    Mass (Da):87,898
    Last modified:July 10, 2007 - v1
    Checksum:i44621CC1B81BC5CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142318 mRNA. Translation: AAI42319.1.
    RefSeqiNP_001092340.1. NM_001098870.2.
    UniGeneiBt.43142.

    Genome annotation databases

    EnsembliENSBTAT00000034643; ENSBTAP00000034530; ENSBTAG00000006591.
    GeneIDi505200.
    KEGGibta:505200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142318 mRNA. Translation: AAI42319.1 .
    RefSeqi NP_001092340.1. NM_001098870.2.
    UniGenei Bt.43142.

    3D structure databases

    ProteinModelPortali A5PK16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000034530.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000034643 ; ENSBTAP00000034530 ; ENSBTAG00000006591 .
    GeneIDi 505200.
    KEGGi bta:505200.

    Organism-specific databases

    CTDi 899.

    Phylogenomic databases

    eggNOGi NOG283043.
    HOGENOMi HOG000285971.
    HOVERGENi HBG050838.
    InParanoidi A5PK16.
    KOi K10289.
    OMAi KSCLQCR.
    OrthoDBi EOG7WDN1V.
    TreeFami TF101006.

    Miscellaneous databases

    NextBioi 20867028.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProi IPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCCNF_BOVIN
    AccessioniPrimary (citable) accession number: A5PK16
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3