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A5PK16

- CCNF_BOVIN

UniProt

A5PK16 - CCNF_BOVIN

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Protein

Cyclin-F

Gene
CCNF
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication By similarity.

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. negative regulation of centrosome duplication Source: UniProtKB
  3. placenta development Source: Ensembl
  4. protein ubiquitination Source: UniProtKB
  5. re-entry into mitotic cell cycle Source: Ensembl
  6. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:CCNF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 25

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Also localizes to the nucleus By similarity.

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Cyclin-FPRO_0000398634Add
BLAST

Post-translational modificationi

Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence By similarity.
Phosphorylated just before cells enter into mitosis By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034530.

Structurei

3D structure databases

ProteinModelPortaliA5PK16.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 7648F-boxAdd
BLAST
Domaini294 – 405112Cyclin N-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni582 – 766185PESTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 289Nuclear localization signal 1 By similarity
Motifi568 – 5747Nuclear localization signal 2 By similarity

Domaini

The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus By similarity.

Sequence similaritiesi

Contains 1 F-box domain.

Phylogenomic databases

eggNOGiNOG283043.
HOGENOMiHOG000285971.
HOVERGENiHBG050838.
InParanoidiA5PK16.
KOiK10289.
OMAiKSCLQCR.
OrthoDBiEOG7WDN1V.
TreeFamiTF101006.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical.
[Graphical view]
PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PK16-1 [UniParc]FASTAAdd to Basket

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MGSGGVIHCR CAKCFCYPSK RRIRRRPRNL TILNLPEDAL FHILKWLSVG    50
DILAVRAVHS HLKYLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF 100
EAAVKLGIAY LYNEGLSVSD EARAEVNGLR ASRYFSLAER LNVGAAPFIW 150
LFIRPPWSVS GSCCKAVVHE SLRAECQLQK THRASILHCL GRVLSLFEDE 200
EKQKQARKLF EESANQGCLT SSYLLWESDR RMDMLDPGRC LHSFRKLRDF 250
AAKGCWEAQL SLAKACAHGH QLGLEAKASS EIVCQLFQAS HAVNKQRVFS 300
VQKGLNDTMR YILIDWLVEV ATMKDFSSLC LHLTVECVDR YLRRRLVPRY 350
RLQLLGIACM VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEVVSA 400
LDGKIRVPTV VDYKDVLLTL VPMAPRTQHL CSFLCELSLL HTSLAAYAPA 450
HLAAAALLLA RLTHGQTQPW TTQLWDLTGF SCEDLIPCVL SLHQKCFHDD 500
APKDYRQVSL TAVKQRFEDK RYEEISLEEV LSYGQLCAAL GVKQESLEPA 550
PFLSAGDIHA FLSSPSARRT KRKRENSLQE DRGSFVTTPT AELSSQEETL 600
LGSFLDWSLD YCSGYEGDQE SEGEKEGDVT APSGVLDVTV VYLSPEEHCC 650
QESSDEEACP EEACGAQDTQ ALVPGHQALR TPGPEPPLCS RWGLGKDVTT 700
SGYSSVNSAS PTDSGRTSGG PPRSTSELPT GSSLNTQPCH HHARKSCLQC 750
RPPSPPESCA PQQQVKRKNL SAHSEEEEED MNLGFLKL 788
Length:788
Mass (Da):87,898
Last modified:July 10, 2007 - v1
Checksum:i44621CC1B81BC5CE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142318 mRNA. Translation: AAI42319.1.
RefSeqiNP_001092340.1. NM_001098870.2.
UniGeneiBt.43142.

Genome annotation databases

EnsembliENSBTAT00000034643; ENSBTAP00000034530; ENSBTAG00000006591.
GeneIDi505200.
KEGGibta:505200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142318 mRNA. Translation: AAI42319.1 .
RefSeqi NP_001092340.1. NM_001098870.2.
UniGenei Bt.43142.

3D structure databases

ProteinModelPortali A5PK16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000034530.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000034643 ; ENSBTAP00000034530 ; ENSBTAG00000006591 .
GeneIDi 505200.
KEGGi bta:505200.

Organism-specific databases

CTDi 899.

Phylogenomic databases

eggNOGi NOG283043.
HOGENOMi HOG000285971.
HOVERGENi HBG050838.
InParanoidi A5PK16.
KOi K10289.
OMAi KSCLQCR.
OrthoDBi EOG7WDN1V.
TreeFami TF101006.

Miscellaneous databases

NextBioi 20867028.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProi IPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical.
[Graphical view ]
PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiCCNF_BOVIN
AccessioniPrimary (citable) accession number: A5PK16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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