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Protein

Cyclin-F

Gene

CCNF

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.By similarity

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-BTA-8951664 Neddylation
R-BTA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:CCNF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Organism-specific databases

VGNCiVGNC:26968 CCNF

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003986341 – 788Cyclin-FAdd BLAST788

Post-translational modificationi

Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence (By similarity).By similarity
Phosphorylated just before cells enter into mitosis.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA5PK16
PRIDEiA5PK16

Expressioni

Gene expression databases

BgeeiENSBTAG00000006591
ExpressionAtlasiA5PK16 baseline

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex consisting of CUL1, RBX1, SKP1 and CCNF. Interacts with CCNB1; interaction is required for nuclear localization of CCNB1. Interacts with CCP110; this interaction leads to CCP110 ubiquitination and degradation via the proteasome pathway (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000034530

Structurei

3D structure databases

ProteinModelPortaliA5PK16
SMRiA5PK16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 76F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini294 – 405Cyclin N-terminalAdd BLAST112

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni582 – 766PESTAdd BLAST185

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi20 – 28Nuclear localization signal 1By similarity9
Motifi568 – 574Nuclear localization signal 2By similarity7

Domaini

The nuclear localization signals mediate the localization to the nucleus and are required for CCNB1 localization to the nucleus.By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00810000125541
HOGENOMiHOG000285971
HOVERGENiHBG050838
InParanoidiA5PK16
KOiK10289
OMAiLHQKCFH
OrthoDBiEOG091G0AU2
TreeFamiTF101006

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR028857 CCNF_metazoan
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR10177:SF252 PTHR10177:SF252, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
PF00646 F-box, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SM00256 FBOX, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

A5PK16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGGVIHCR CAKCFCYPSK RRIRRRPRNL TILNLPEDAL FHILKWLSVG
60 70 80 90 100
DILAVRAVHS HLKYLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF
110 120 130 140 150
EAAVKLGIAY LYNEGLSVSD EARAEVNGLR ASRYFSLAER LNVGAAPFIW
160 170 180 190 200
LFIRPPWSVS GSCCKAVVHE SLRAECQLQK THRASILHCL GRVLSLFEDE
210 220 230 240 250
EKQKQARKLF EESANQGCLT SSYLLWESDR RMDMLDPGRC LHSFRKLRDF
260 270 280 290 300
AAKGCWEAQL SLAKACAHGH QLGLEAKASS EIVCQLFQAS HAVNKQRVFS
310 320 330 340 350
VQKGLNDTMR YILIDWLVEV ATMKDFSSLC LHLTVECVDR YLRRRLVPRY
360 370 380 390 400
RLQLLGIACM VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEVVSA
410 420 430 440 450
LDGKIRVPTV VDYKDVLLTL VPMAPRTQHL CSFLCELSLL HTSLAAYAPA
460 470 480 490 500
HLAAAALLLA RLTHGQTQPW TTQLWDLTGF SCEDLIPCVL SLHQKCFHDD
510 520 530 540 550
APKDYRQVSL TAVKQRFEDK RYEEISLEEV LSYGQLCAAL GVKQESLEPA
560 570 580 590 600
PFLSAGDIHA FLSSPSARRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
610 620 630 640 650
LGSFLDWSLD YCSGYEGDQE SEGEKEGDVT APSGVLDVTV VYLSPEEHCC
660 670 680 690 700
QESSDEEACP EEACGAQDTQ ALVPGHQALR TPGPEPPLCS RWGLGKDVTT
710 720 730 740 750
SGYSSVNSAS PTDSGRTSGG PPRSTSELPT GSSLNTQPCH HHARKSCLQC
760 770 780
RPPSPPESCA PQQQVKRKNL SAHSEEEEED MNLGFLKL
Length:788
Mass (Da):87,898
Last modified:July 10, 2007 - v1
Checksum:i44621CC1B81BC5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142318 mRNA Translation: AAI42319.1
RefSeqiNP_001092340.1, NM_001098870.2
UniGeneiBt.43142

Genome annotation databases

EnsembliENSBTAT00000034643; ENSBTAP00000034530; ENSBTAG00000006591
GeneIDi505200
KEGGibta:505200

Similar proteinsi

Entry informationi

Entry nameiCCNF_BOVIN
AccessioniPrimary (citable) accession number: A5PK16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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