ID   A5PJZ7_BOVIN            Unreviewed;      1129 AA.
AC   A5PJZ7;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   SubName: Full=HDAC6 protein {ECO:0000313|EMBL:AAI42299.1};
GN   Name=HDAC6 {ECO:0000313|EMBL:AAI42299.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI42299.1};
RN   [1] {ECO:0000313|EMBL:AAI42299.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Hereford {ECO:0000313|EMBL:AAI42299.1};
RC   TISSUE=Thymus {ECO:0000313|EMBL:AAI42299.1};
RA   Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA   Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA   Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA   Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA   Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA   Holt R., Jones S.J., Marra M.A.;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; BC142298; AAI42299.1; -; mRNA.
DR   RefSeq; NP_001092430.1; NM_001098960.1.
DR   AlphaFoldDB; A5PJZ7; -.
DR   GeneID; 513602; -.
DR   KEGG; bta:513602; -.
DR   CTD; 10013; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd10003; HDAC6-dom2; 1.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR10625:SF22; HISTONE DEACETYLASE 6; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00502};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00502};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00502}.
FT   DOMAIN          1025..1123
FT                   /note="UBP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50271"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          843..866
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        851..866
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        885..918
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1129 AA;  123975 MW;  C11FD28F15597D13 CRC64;
     MTSTGQDSTT PKERRSRHNP HSPTHDSSIT SKRGVKKSAI LRSSPSLAEV KKKGRMKKLS
     QTAEQDLIMG LQGLNLNLES RTLSGTGLVF DEQLNEFHCL WDDSFPERPE RLHAIKEQLI
     QEGLLDRCVS FQARFAEKEE LMLVHSLEYI DLMETTQYMN EEELHVLADT YDSVYLHPNS
     YTCACLASGS VLRLVDAVLE AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ
     KHDIQRVLIV DWDVHHGQGI QFAFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGLGQG
     QGYTINVPWN QVGMQDADYI AAFLHVLLPV AFEFQPQLVL VAAGFDALQG DPKGEMAATP
     AGFAQLTHLL MGLAEGKLIL SLEGGYNLHS LAEGVSATLH TLLGDPCPVL ESPGAPCPSA
     QASLSCTLEA LEPFWESLVR SVESLEEKDT VEKDDVEEKE EERLPQSPEL SVPIWPVLQA
     RTGLVYDQQM MDHHNLWDNY HPEMPQRIHF IMHHLDELGL AKRCHSLPAR PATDAELLTC
     HSAEHLERLR ATEKMKTREL RREGANYDSI YICSSTFACA QLAAGAACRL VEAVLAGEVL
     NGVAVVRPPG HHAEPDAACG FCFFNSVAVA ARHAQAISGH ALRILIVDWD IHHGNGTQHI
     FEEDPSVLYI SLHRYDHGTF FPMGNEGACT RIGKATGTGF TVNVAWNGPR MGDADYLAAW
     HRLVLPVAYE FNPELVLVSA GFDAARGDPL GGCQVSPEGY AHLTHQLMGL ANGHIILILE
     GGYNLTSISE SMAACTRSLL GDPLPLLTRL RPPLSGAQAS ITKTIQVHRR YWRSLRVMKR
     KNKEELSSSK LITKKPSQPA SPGLANVTTT VEGNILETGM GQAASEASVK ESTPDQTESA
     TAPVELTQGQ SSDTATQGAA LDQTISEGAT GGAELIQNPP ASCINNRIPP ALPVQGATAQ
     TSPSKLMANL RILDLDSTTQ EPSEEEGLLG EAAGGQDTNE SVPVQVFGDH ADTDEVMFYA
     VRPLLWCPHL AAVCPIPETG LNVTQPCQYC GTLQENWVCL SCYQVYCGRY INAHMLQHHE
     GSGHPLVLSY ADLSAWCYHC QAYVHHKDLL AVKNIAHQNK FGEDIPHSD
//