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Protein

Histone deacetylase

Gene

HDAC6

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1045 – 1106UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:HDAC6Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiA5PJZ7.

Structurei

3D structure databases

ProteinModelPortaliA5PJZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1045 – 1106UBP-typeInterPro annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1045 – 1106UBP-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000004769.
HOVERGENiHBG051894.
KOiK11407.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
PRINTSiPR01270. HDASUPER.
SMARTiView protein in SMART
SM00290. ZnF_UBP. 1 hit.
PROSITEiView protein in PROSITE
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

A5PJZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSTT PKERRSRHNP HSPTHDSSIT SKRGVKKSAI LRSSPSLAEV
60 70 80 90 100
KKKGRMKKLS QTAEQDLIMG LQGLNLNLES RTLSGTGLVF DEQLNEFHCL
110 120 130 140 150
WDDSFPERPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI
160 170 180 190 200
DLMETTQYMN EEELHVLADT YDSVYLHPNS YTCACLASGS VLRLVDAVLE
210 220 230 240 250
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHDIQRVLIV
260 270 280 290 300
DWDVHHGQGI QFAFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGLGQG
310 320 330 340 350
QGYTINVPWN QVGMQDADYI AAFLHVLLPV AFEFQPQLVL VAAGFDALQG
360 370 380 390 400
DPKGEMAATP AGFAQLTHLL MGLAEGKLIL SLEGGYNLHS LAEGVSATLH
410 420 430 440 450
TLLGDPCPVL ESPGAPCPSA QASLSCTLEA LEPFWESLVR SVESLEEKDT
460 470 480 490 500
VEKDDVEEKE EERLPQSPEL SVPIWPVLQA RTGLVYDQQM MDHHNLWDNY
510 520 530 540 550
HPEMPQRIHF IMHHLDELGL AKRCHSLPAR PATDAELLTC HSAEHLERLR
560 570 580 590 600
ATEKMKTREL RREGANYDSI YICSSTFACA QLAAGAACRL VEAVLAGEVL
610 620 630 640 650
NGVAVVRPPG HHAEPDAACG FCFFNSVAVA ARHAQAISGH ALRILIVDWD
660 670 680 690 700
IHHGNGTQHI FEEDPSVLYI SLHRYDHGTF FPMGNEGACT RIGKATGTGF
710 720 730 740 750
TVNVAWNGPR MGDADYLAAW HRLVLPVAYE FNPELVLVSA GFDAARGDPL
760 770 780 790 800
GGCQVSPEGY AHLTHQLMGL ANGHIILILE GGYNLTSISE SMAACTRSLL
810 820 830 840 850
GDPLPLLTRL RPPLSGAQAS ITKTIQVHRR YWRSLRVMKR KNKEELSSSK
860 870 880 890 900
LITKKPSQPA SPGLANVTTT VEGNILETGM GQAASEASVK ESTPDQTESA
910 920 930 940 950
TAPVELTQGQ SSDTATQGAA LDQTISEGAT GGAELIQNPP ASCINNRIPP
960 970 980 990 1000
ALPVQGATAQ TSPSKLMANL RILDLDSTTQ EPSEEEGLLG EAAGGQDTNE
1010 1020 1030 1040 1050
SVPVQVFGDH ADTDEVMFYA VRPLLWCPHL AAVCPIPETG LNVTQPCQYC
1060 1070 1080 1090 1100
GTLQENWVCL SCYQVYCGRY INAHMLQHHE GSGHPLVLSY ADLSAWCYHC
1110 1120
QAYVHHKDLL AVKNIAHQNK FGEDIPHSD
Length:1,129
Mass (Da):123,975
Last modified:July 10, 2007 - v1
Checksum:iC11FD28F15597D13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142298 mRNA. Translation: AAI42299.1.
RefSeqiNP_001092430.1. NM_001098960.1.
UniGeneiBt.76413.

Genome annotation databases

GeneIDi513602.
KEGGibta:513602.

Similar proteinsi

Entry informationi

Entry nameiA5PJZ7_BOVIN
AccessioniPrimary (citable) accession number: A5PJZ7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: August 30, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)