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A5PJZ2 (PPM1L_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1L

EC=3.1.3.16
Alternative name(s):
Protein phosphatase 1-like
Protein phosphatase 2C isoform epsilon
Short name=PP2C-epsilon
Gene names
Name:PPM1L
Synonyms:PP2CE
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subunit structure

Interacts with MAP3K7/TAK1 and MAP3K5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Protein phosphatase 1L
PRO_0000354704

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4217Helical; Potential
Topological domain43 – 360318Cytoplasmic Potential
Domain91 – 344254PP2C-like

Sites

Metal binding1281Manganese 1 By similarity
Metal binding1281Manganese 2 By similarity
Metal binding1291Manganese 1; via carbonyl oxygen By similarity
Metal binding3021Manganese 2 By similarity
Metal binding3421Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5PJZ2 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 4BD0763B7B2AF8D7

FASTA36041,042
        10         20         30         40         50         60 
MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK SSRDAVKMVK 

        70         80         90        100        110        120 
GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG RRDHMEDRFE VLMDLANKTH 

       130        140        150        160        170        180 
PSIFGIFDGH GGETAAEYVK SRLPEALKQH LQDYEKDKEN SVLSYQTILE QQILSIDREM 

       190        200        210        220        230        240 
LEKLTVSYDE AGTTCLIALL SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK 

       250        260        270        280        290        300 
RIKRAGGFIS FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 

       310        320        330        340        350        360 
SDGLWDAFSN EEAVRFIKDR LDEPHFGAKS IVLQSFYRGC PDNITVMVVK FRNSSKTEEQ 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC142293 mRNA. Translation: AAI42294.1.
RefSeqNP_001092588.1. NM_001099118.2.
UniGeneBt.50536.

3D structure databases

ProteinModelPortalA5PJZ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001677.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000053250; ENSBTAP00000050151; ENSBTAG00000001274.
GeneID541235.
KEGGbta:541235.

Organism-specific databases

CTD151742.

Phylogenomic databases

eggNOGCOG0631.
GeneTreeENSGT00740000114971.
HOGENOMHOG000233896.
HOVERGENHBG079483.
InParanoidA5PJZ2.
KOK17506.
OMAMMQNERF.
OrthoDBEOG74J98W.
TreeFamTF332888.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20879085.

Entry information

Entry namePPM1L_BOVIN
AccessionPrimary (citable) accession number: A5PJZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 10, 2007
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families