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A5PJZ2

- PPM1L_BOVIN

UniProt

A5PJZ2 - PPM1L_BOVIN

Protein

Protein phosphatase 1L

Gene

PPM1L

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281Manganese 1By similarity
    Metal bindingi128 – 1281Manganese 2By similarity
    Metal bindingi129 – 1291Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi302 – 3021Manganese 2By similarity
    Metal bindingi342 – 3421Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: Ensembl

    GO - Biological processi

    1. MAPK cascade Source: Ensembl
    2. protein dephosphorylation Source: InterPro
    3. transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_204257. Sphingolipid de novo biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1L (EC:3.1.3.16)
    Alternative name(s):
    Protein phosphatase 1-like
    Protein phosphatase 2C isoform epsilon
    Short name:
    PP2C-epsilon
    Gene namesi
    Name:PPM1L
    Synonyms:PP2CE
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360Protein phosphatase 1LPRO_0000354704Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with MAP3K7/TAK1 and MAP3K5.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000001677.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PJZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 360318CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4217HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 344254PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0631.
    GeneTreeiENSGT00740000114971.
    HOGENOMiHOG000233896.
    HOVERGENiHBG079483.
    InParanoidiA5PJZ2.
    KOiK17506.
    OMAiMMQNERF.
    OrthoDBiEOG74J98W.
    TreeFamiTF332888.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5PJZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK    50
    SSRDAVKMVK GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG 100
    RRDHMEDRFE VLMDLANKTH PSIFGIFDGH GGETAAEYVK SRLPEALKQH 150
    LQDYEKDKEN SVLSYQTILE QQILSIDREM LEKLTVSYDE AGTTCLIALL 200
    SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK RIKRAGGFIS 250
    FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA 300
    SDGLWDAFSN EEAVRFIKDR LDEPHFGAKS IVLQSFYRGC PDNITVMVVK 350
    FRNSSKTEEQ 360
    Length:360
    Mass (Da):41,042
    Last modified:July 10, 2007 - v1
    Checksum:i4BD0763B7B2AF8D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142293 mRNA. Translation: AAI42294.1.
    RefSeqiNP_001092588.1. NM_001099118.2.
    UniGeneiBt.50536.

    Genome annotation databases

    EnsembliENSBTAT00000053250; ENSBTAP00000050151; ENSBTAG00000001274.
    GeneIDi541235.
    KEGGibta:541235.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142293 mRNA. Translation: AAI42294.1 .
    RefSeqi NP_001092588.1. NM_001099118.2.
    UniGenei Bt.50536.

    3D structure databases

    ProteinModelPortali A5PJZ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000001677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000053250 ; ENSBTAP00000050151 ; ENSBTAG00000001274 .
    GeneIDi 541235.
    KEGGi bta:541235.

    Organism-specific databases

    CTDi 151742.

    Phylogenomic databases

    eggNOGi COG0631.
    GeneTreei ENSGT00740000114971.
    HOGENOMi HOG000233896.
    HOVERGENi HBG079483.
    InParanoidi A5PJZ2.
    KOi K17506.
    OMAi MMQNERF.
    OrthoDBi EOG74J98W.
    TreeFami TF332888.

    Enzyme and pathway databases

    Reactomei REACT_204257. Sphingolipid de novo biosynthesis.

    Miscellaneous databases

    NextBioi 20879085.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiPPM1L_BOVIN
    AccessioniPrimary (citable) accession number: A5PJZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3