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Protein

Protein phosphatase 1L

Gene

PPM1L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281Manganese 1By similarity
Metal bindingi128 – 1281Manganese 2By similarity
Metal bindingi129 – 1291Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi302 – 3021Manganese 2By similarity
Metal bindingi342 – 3421Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. protein dephosphorylation Source: InterPro
  3. transmembrane receptor protein serine/threonine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_282069. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1L (EC:3.1.3.16)
Alternative name(s):
Protein phosphatase 1-like
Protein phosphatase 2C isoform epsilon
Short name:
PP2C-epsilon
Gene namesi
Name:PPM1L
Synonyms:PP2CE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4217HelicalSequence AnalysisAdd
BLAST
Topological domaini43 – 360318CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Protein phosphatase 1LPRO_0000354704Add
BLAST

Interactioni

Subunit structurei

Interacts with MAP3K7/TAK1 and MAP3K5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001677.

Structurei

3D structure databases

ProteinModelPortaliA5PJZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 351260PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000233896.
HOVERGENiHBG079483.
InParanoidiA5PJZ2.
KOiK17506.
OMAiVDRDMLD.
OrthoDBiEOG74J98W.
TreeFamiTF332888.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEDTMTLLS LLGRIMRYFL LRPETLFLLC ISLALWSYFF HTDEVKTIVK
60 70 80 90 100
SSRDAVKMVK GKVAEIMQND RLGGLDVLEA EFSKTWEFKS HNVAVYSIQG
110 120 130 140 150
RRDHMEDRFE VLMDLANKTH PSIFGIFDGH GGETAAEYVK SRLPEALKQH
160 170 180 190 200
LQDYEKDKEN SVLSYQTILE QQILSIDREM LEKLTVSYDE AGTTCLIALL
210 220 230 240 250
SDKDLTVANV GDSRGVLCDK DGNAIPLSHD HKPYQLKERK RIKRAGGFIS
260 270 280 290 300
FNGSWRVQGI LAMSRSLGDY PLKNLNVVIP DPDILTFDLD KLQPEFMILA
310 320 330 340 350
SDGLWDAFSN EEAVRFIKDR LDEPHFGAKS IVLQSFYRGC PDNITVMVVK
360
FRNSSKTEEQ
Length:360
Mass (Da):41,042
Last modified:July 10, 2007 - v1
Checksum:i4BD0763B7B2AF8D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142293 mRNA. Translation: AAI42294.1.
RefSeqiNP_001092588.1. NM_001099118.2.
UniGeneiBt.50536.

Genome annotation databases

EnsembliENSBTAT00000053250; ENSBTAP00000050151; ENSBTAG00000001274.
GeneIDi541235.
KEGGibta:541235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142293 mRNA. Translation: AAI42294.1.
RefSeqiNP_001092588.1. NM_001099118.2.
UniGeneiBt.50536.

3D structure databases

ProteinModelPortaliA5PJZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000053250; ENSBTAP00000050151; ENSBTAG00000001274.
GeneIDi541235.
KEGGibta:541235.

Organism-specific databases

CTDi151742.

Phylogenomic databases

eggNOGiCOG0631.
GeneTreeiENSGT00740000114971.
HOGENOMiHOG000233896.
HOVERGENiHBG079483.
InParanoidiA5PJZ2.
KOiK17506.
OMAiVDRDMLD.
OrthoDBiEOG74J98W.
TreeFamiTF332888.

Enzyme and pathway databases

ReactomeiREACT_282069. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi20879085.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPPM1L_BOVIN
AccessioniPrimary (citable) accession number: A5PJZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: July 10, 2007
Last modified: April 1, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.