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Protein

Sodium- and chloride-dependent GABA transporter 2

Gene

SLC6A13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-BTA-888593. Reuptake of GABA.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 2
Short name:
GAT-2
Alternative name(s):
Solute carrier family 6 member 13
Gene namesi
Name:SLC6A13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence analysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei121 – 14121Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini142 – 20665ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei233 – 25321Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei282 – 30221Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei319 – 33921Helical; Name=7Sequence analysisAdd
BLAST
Transmembranei366 – 38621Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei453 – 47321Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei490 – 51021Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini549 – 60254CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Sodium- and chloride-dependent GABA transporter 2PRO_0000351503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi153 ↔ 162By similarity
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence analysis
Modified residuei587 – 5871PhosphothreonineBy similarity
Modified residuei591 – 5911PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA5PJX7.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019308.

Structurei

3D structure databases

ProteinModelPortaliA5PJX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiA5PJX7.
KOiK05039.
OMAiNTEYCVE.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002981. Na/ntran_symport_GABA_GAT2.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01196. GAT2TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRVSGTTS NGETKPVCPG LEKAAEDGAL QREQWSNKME FLLSVAGEII
60 70 80 90 100
GLGNVWRFPY LCYKNGGGAF FIPYLIFLFT CGIPVFLLET ALGQYTSQGG
110 120 130 140 150
ITAWRKICPI FEGIGYASQM IVTLLNIYYI IVLAWALFYL FSSFTIDLPW
160 170 180 190 200
GSCRHDWNTE RCVEFQRTNG SLNATAENAT SPVIEFWERR VLKISEGIQH
210 220 230 240 250
LGALRWELAL CLLLAWVVCY FCIWKGVKST GKVVYFTATF PYLMLVVLLI
260 270 280 290 300
RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
310 320 330 340 350
GSYNKYHNNC YRDSIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV
360 370 380 390 400
AESGPGLAFI AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT
410 420 430 440 450
ALVDMYPRVF RKKNRREVLI LGVSVTSFLV GLVMLTEGGM YVFQLFDYYA
460 470 480 490 500
ASGMCLLFVA IFESFCVAWA YGAGRFYDNI EDMIGYRPWP LIKYCWLFLT
510 520 530 540 550
PAVCTATFLF SLIKYTPLTY NKKYKYPWWG DALGWLLALS SMVCIPAWSC
560 570 580 590 600
YKLSTLKGSF RERVRQLLCP AKDLPQGHRE GPSAPATPRT SLLILTELEP

HH
Length:602
Mass (Da):67,788
Last modified:July 10, 2007 - v1
Checksum:i8B378732075B9F07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142276 mRNA. Translation: AAI42277.1.
RefSeqiNP_001092497.1. NM_001099027.1.
UniGeneiBt.56707.

Genome annotation databases

EnsembliENSBTAT00000019308; ENSBTAP00000019308; ENSBTAG00000014525.
GeneIDi523784.
KEGGibta:523784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142276 mRNA. Translation: AAI42277.1.
RefSeqiNP_001092497.1. NM_001099027.1.
UniGeneiBt.56707.

3D structure databases

ProteinModelPortaliA5PJX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019308.

Proteomic databases

PaxDbiA5PJX7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019308; ENSBTAP00000019308; ENSBTAG00000014525.
GeneIDi523784.
KEGGibta:523784.

Organism-specific databases

CTDi6540.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiA5PJX7.
KOiK05039.
OMAiNTEYCVE.
OrthoDBiEOG793B71.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-BTA-442660. Na+/Cl- dependent neurotransmitter transporters.
R-BTA-888593. Reuptake of GABA.

Miscellaneous databases

NextBioi20873826.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002981. Na/ntran_symport_GABA_GAT2.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01196. GAT2TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal medulla.

Entry informationi

Entry nameiS6A13_BOVIN
AccessioniPrimary (citable) accession number: A5PJX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 10, 2007
Last modified: February 17, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.