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Protein

Sodium- and chloride-dependent GABA transporter 2

Gene

SLC6A13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-442660 Na+/Cl- dependent neurotransmitter transporters
R-BTA-888593 Reuptake of GABA

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 2
Short name:
GAT-2
Alternative name(s):
Solute carrier family 6 member 13
Gene namesi
Name:SLC6A13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:34916 SLC6A13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei121 – 141Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini142 – 206ExtracellularSequence analysisAdd BLAST65
Transmembranei207 – 227Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei233 – 253Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei282 – 302Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei319 – 339Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei366 – 386Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei418 – 438Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei453 – 473Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei490 – 510Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei528 – 548Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini549 – 602CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003515031 – 602Sodium- and chloride-dependent GABA transporter 2Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi153 ↔ 162By similarity
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei587PhosphothreonineBy similarity1
Modified residuei591PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiA5PJX7
PRIDEiA5PJX7

Expressioni

Gene expression databases

BgeeiENSBTAG00000014525

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019308

Structurei

3D structure databases

ProteinModelPortaliA5PJX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiA5PJX7
KOiK05039
OMAiFQRTNGS
OrthoDBiEOG091G08PX
TreeFamiTF343812

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002981 Na/ntran_symport_GABA_GAT2
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01196 GAT2TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

A5PJX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSRVSGTTS NGETKPVCPG LEKAAEDGAL QREQWSNKME FLLSVAGEII
60 70 80 90 100
GLGNVWRFPY LCYKNGGGAF FIPYLIFLFT CGIPVFLLET ALGQYTSQGG
110 120 130 140 150
ITAWRKICPI FEGIGYASQM IVTLLNIYYI IVLAWALFYL FSSFTIDLPW
160 170 180 190 200
GSCRHDWNTE RCVEFQRTNG SLNATAENAT SPVIEFWERR VLKISEGIQH
210 220 230 240 250
LGALRWELAL CLLLAWVVCY FCIWKGVKST GKVVYFTATF PYLMLVVLLI
260 270 280 290 300
RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL
310 320 330 340 350
GSYNKYHNNC YRDSIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV
360 370 380 390 400
AESGPGLAFI AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT
410 420 430 440 450
ALVDMYPRVF RKKNRREVLI LGVSVTSFLV GLVMLTEGGM YVFQLFDYYA
460 470 480 490 500
ASGMCLLFVA IFESFCVAWA YGAGRFYDNI EDMIGYRPWP LIKYCWLFLT
510 520 530 540 550
PAVCTATFLF SLIKYTPLTY NKKYKYPWWG DALGWLLALS SMVCIPAWSC
560 570 580 590 600
YKLSTLKGSF RERVRQLLCP AKDLPQGHRE GPSAPATPRT SLLILTELEP

HH
Length:602
Mass (Da):67,788
Last modified:July 10, 2007 - v1
Checksum:i8B378732075B9F07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142276 mRNA Translation: AAI42277.1
RefSeqiNP_001092497.1, NM_001099027.1
UniGeneiBt.56707

Genome annotation databases

EnsembliENSBTAT00000019308; ENSBTAP00000019308; ENSBTAG00000014525
GeneIDi523784
KEGGibta:523784

Similar proteinsi

Entry informationi

Entry nameiS6A13_BOVIN
AccessioniPrimary (citable) accession number: A5PJX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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