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Protein
Submitted name:

NGFR protein

Gene

NGFR

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-193634 Axonal growth inhibition (RHOA activation)
R-BTA-193692 Regulated proteolysis of p75NTR
R-BTA-205017 NFG and proNGF binds to p75NTR
R-BTA-205025 NADE modulates death signalling
R-BTA-205043 NRIF signals cell death from the nucleus
R-BTA-209543 p75NTR recruits signalling complexes
R-BTA-209560 NF-kB is activated and signals survival
R-BTA-209563 Axonal growth stimulation

Names & Taxonomyi

Protein namesi
Submitted name:
NGFR proteinImported
Submitted name:
Nerve growth factor receptorImported
Gene namesi
Name:NGFRImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:32062 NGFR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501408385631 – 429Sequence analysisAdd BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 59PROSITE-ProRule annotation
Disulfide bondi88 ↔ 101PROSITE-ProRule annotation
Disulfide bondi91 ↔ 109PROSITE-ProRule annotation
Disulfide bondi127 ↔ 140PROSITE-ProRule annotation
Disulfide bondi130 ↔ 148PROSITE-ProRule annotation
Disulfide bondi151 ↔ 166PROSITE-ProRule annotation
Disulfide bondi169 ↔ 182PROSITE-ProRule annotation
Disulfide bondi172 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSBTAG00000020979

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027940

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 66TNFR-CysInterPro annotationAdd BLAST34
Repeati33 – 66TNFR-CysPROSITE-ProRule annotationAdd BLAST34
Domaini68 – 109TNFR-CysInterPro annotationAdd BLAST42
Repeati68 – 109TNFR-CysPROSITE-ProRule annotationAdd BLAST42
Domaini110 – 148TNFR-CysInterPro annotationAdd BLAST39
Repeati110 – 148TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini150 – 190TNFR-CysInterPro annotationAdd BLAST41
Repeati150 – 190TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini346 – 423DeathInterPro annotationAdd BLAST78

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC Eukaryota
ENOG4111F3C LUCA
GeneTreeiENSGT00730000110974
HOGENOMiHOG000059587
HOVERGENiHBG060431
KOiK02583
OMAiAQPCGAN
OrthoDBiEOG091G0M0X
TreeFamiTF106466

Family and domain databases

CDDicd13416 TNFRSF16, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022325 TNFR_16
IPR034046 TNFRSF16_N
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01966 TNFACTORR16
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 4 hits

Sequencei

Sequence statusi: Complete.

A5PJV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGAAGRAM DGPRLLLLLL LLLGVSLGGA KEACLTGLYT HSGECCKACN
60 70 80 90 100
LGEGVAQPCG ANQTVCEPCL DSVTFSDVVS ATEPCKPCTE CVGLQSMSAP
110 120 130 140 150
CVEADDAVCR CAYGYYQDET TGRCEACRVC EAGSGLVFSC QDKQNTVCEE
160 170 180 190 200
CPDGTYSDEA NHVDPCLPCT VCEDTERQLR ECTRWADAEC EEIPGRWITR
210 220 230 240 250
ATPPEGSDST DPSTQEPEVP PEQDLVTSTV SDVVTTVMGS SQPVVTRGTA
260 270 280 290 300
DNLIPVYCSI LAAVVVGLVA YIAFKRWNSC KQNKQGANSR PVNQTPPPEG
310 320 330 340 350
EKLHSDSGIS VDSQSLHDQQ PHTQTAAGQA LKGDGGLYSS LPLAKREEVE
360 370 380 390 400
KLLNGSAGDT WRHLAGELGY QPEHIDSFTH EACPARALLA SWAAQDSATL
410 420
DTLLAALRRI QRADIVESLC SESTATSPV
Length:429
Mass (Da):45,500
Last modified:July 10, 2007 - v1
Checksum:i0AABF962244546D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02049049 Genomic DNA No translation available.
DAAA02049050 Genomic DNA No translation available.
BC142255 mRNA Translation: AAI42256.1
RefSeqiNP_001095948.1, NM_001102478.2
UniGeneiBt.11338

Genome annotation databases

EnsembliENSBTAT00000027940; ENSBTAP00000027940; ENSBTAG00000020979
GeneIDi353110
KEGGibta:353110

Similar proteinsi

Entry informationi

Entry nameiA5PJV7_BOVIN
AccessioniPrimary (citable) accession number: A5PJV7
Secondary accession number(s): F1MBH2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported