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Protein
Submitted name:

NGFR protein

Gene

NGFR

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-193634. Axonal growth inhibition (RHOA activation).
R-BTA-193692. Regulated proteolysis of p75NTR.
R-BTA-205017. NFG and proNGF binds to p75NTR.
R-BTA-205025. NADE modulates death signalling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-209563. Axonal growth stimulation.

Names & Taxonomyi

Protein namesi
Submitted name:
NGFR proteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:NGFRImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500763545931 – 429Sequence analysisAdd BLAST399

Expressioni

Gene expression databases

BgeeiENSBTAG00000020979.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027940.

Structurei

3D structure databases

ProteinModelPortaliA5PJV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 66TNFR-CysInterPro annotationAdd BLAST34
Domaini68 – 109TNFR-CysInterPro annotationAdd BLAST42
Domaini110 – 148TNFR-CysInterPro annotationAdd BLAST39
Domaini150 – 190TNFR-CysInterPro annotationAdd BLAST41
Domaini346 – 423DeathInterPro annotationAdd BLAST78

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
KOiK02583.
OMAiAQPCGAN.
OrthoDBiEOG091G0M0X.
TreeFamiTF106466.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSGAAGRAM DGPRLLLLLL LLLGVSLGGA KEACLTGLYT HSGECCKACN
60 70 80 90 100
LGEGVAQPCG ANQTVCEPCL DSVTFSDVVS ATEPCKPCTE CVGLQSMSAP
110 120 130 140 150
CVEADDAVCR CAYGYYQDET TGRCEACRVC EAGSGLVFSC QDKQNTVCEE
160 170 180 190 200
CPDGTYSDEA NHVDPCLPCT VCEDTERQLR ECTRWADAEC EEIPGRWITR
210 220 230 240 250
ATPPEGSDST DPSTQEPEVP PEQDLVTSTV SDVVTTVMGS SQPVVTRGTA
260 270 280 290 300
DNLIPVYCSI LAAVVVGLVA YIAFKRWNSC KQNKQGANSR PVNQTPPPEG
310 320 330 340 350
EKLHSDSGIS VDSQSLHDQQ PHTQTAAGQA LKGDGGLYSS LPLAKREEVE
360 370 380 390 400
KLLNGSAGDT WRHLAGELGY QPEHIDSFTH EACPARALLA SWAAQDSATL
410 420
DTLLAALRRI QRADIVESLC SESTATSPV
Length:429
Mass (Da):45,500
Last modified:July 10, 2007 - v1
Checksum:i0AABF962244546D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02049049 Genomic DNA. No translation available.
DAAA02049050 Genomic DNA. No translation available.
BC142255 mRNA. Translation: AAI42256.1.
RefSeqiNP_001095948.1. NM_001102478.2.
UniGeneiBt.11338.

Genome annotation databases

EnsembliENSBTAT00000027940; ENSBTAP00000027940; ENSBTAG00000020979.
GeneIDi353110.
KEGGibta:353110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02049049 Genomic DNA. No translation available.
DAAA02049050 Genomic DNA. No translation available.
BC142255 mRNA. Translation: AAI42256.1.
RefSeqiNP_001095948.1. NM_001102478.2.
UniGeneiBt.11338.

3D structure databases

ProteinModelPortaliA5PJV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027940; ENSBTAP00000027940; ENSBTAG00000020979.
GeneIDi353110.
KEGGibta:353110.

Organism-specific databases

CTDi4804.

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
KOiK02583.
OMAiAQPCGAN.
OrthoDBiEOG091G0M0X.
TreeFamiTF106466.

Enzyme and pathway databases

ReactomeiR-BTA-193634. Axonal growth inhibition (RHOA activation).
R-BTA-193692. Regulated proteolysis of p75NTR.
R-BTA-205017. NFG and proNGF binds to p75NTR.
R-BTA-205025. NADE modulates death signalling.
R-BTA-205043. NRIF signals cell death from the nucleus.
R-BTA-209543. p75NTR recruits signalling complexes.
R-BTA-209560. NF-kB is activated and signals survival.
R-BTA-209563. Axonal growth stimulation.

Gene expression databases

BgeeiENSBTAG00000020979.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5PJV7_BOVIN
AccessioniPrimary (citable) accession number: A5PJV7
Secondary accession number(s): F1MBH2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.