A5PJV3 (HUTI_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable imidazolonepropionase
EC=3.5.2.7

Alternative name(s):
Amidohydrolase domain-containing protein 1

Gene names

Name:

AMDHD1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.
Cofactor	Binds 1 zinc or iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
Sequence similarities	Belongs to the HutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 426	426	Probable imidazolonepropionase		PRO_0000314849
Sites
	Metal binding	87	1	Zinc or iron By similarity
	Metal binding	89	1	Zinc or iron By similarity
	Metal binding	260	1	Zinc or iron By similarity
	Metal binding	334	1	Zinc or iron By similarity
	Binding site	96	1	Substrate By similarity
	Binding site	109	1	Substrate By similarity
	Binding site	159	1	Substrate By similarity
	Binding site	192	1	Substrate By similarity
	Binding site	263	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5PJV3 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 4FB869F59608701B	FASTA	426	46,749
	10 20 30 40 50 60 MAGGHRLLLE NARQVVLVCA RGERFLTRDA LRSLEVLEGA SLVVGTDGFI KAIGPADAIQ 70 80 90 100 110 120 KQFSEETFEE RIDCSGKCIL PGLVDAHTHP VWAGERVHEF AMKLAGATYM DIHQAGGGIN 130 140 150 160 170 180 FTVERTRQAS EEELYSSFQQ RLGCMMRAGT TLVECKSGYG LNLETELKML RVIERARQEL 190 200 210 220 230 240 DIGISATYCG AHSVPKGKTA SEAADDIIKN HLPRLKELGR NGEIHVDNID VFCEKDVFDL 250 260 270 280 290 300 DSTRRILQSG KDIGLQINFH GDELHPMKAA ELGVELGAQA ISHLEEVSDE GIAAMASARC 310 320 330 340 350 360 SAVLLPTTAY MLRLKQPRAR KMLDEGVIVA LGSDFNPNAY CFSMPMVMHL ACVNMRMSMP 370 380 390 400 410 420 EALAAATINA AYALGKSHTQ GSLEVGKQGD LIIINSPRWE HLIYQFGGHH ELIDYVIAKG KVIYKK

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC142251 mRNA. Translation: AAI42252.1.
IPI	IPI00712354.
RefSeq	NP_001092342.1. NM_001098872.1.
UniGene	Bt.24628.
3D structure databases
ProteinModelPortal	A5PJV3.
ModBase	Search...
Protein-protein interaction databases
STRING	A5PJV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000021647; ENSBTAP00000021647; ENSBTAG00000016275.
GeneID	505315.
KEGG	bta:505315.
Organism-specific databases
CTD	144193.
Phylogenomic databases
eggNOG	maNOG07499.
GeneTree	ENSGT00390000008645.
HOVERGEN	HBG054263.
InParanoid	A5PJV3.
OrthoDB	EOG4RR6HC.
Family and domain databases
InterPro	IPR013108. Amidohydro_3. IPR005920. HutI. [Graphical view]
KO	K01468.
PANTHER	PTHR22642. PTHR22642. 1 hit.
Pfam	PF07969. Amidohydro_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01224. HutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_BOVIN

Accession

Primary (citable) accession number: A5PJV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program