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A5PJS2

- S5A1_BOVIN

UniProt

A5PJS2 - S5A1_BOVIN

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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene
SRD5A1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

GO - Molecular functioni

  1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. androgen biosynthetic process Source: Ensembl
  2. cell differentiation Source: UniProtKB-KW
  3. sex differentiation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_212422. Androgen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:SRD5A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 20

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST
Transmembranei50 – 7021Helical; Reviewed predictionAdd
BLAST
Transmembranei84 – 10421Helical; Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Transmembranei149 – 16921Helical; Reviewed predictionAdd
BLAST
Transmembranei208 – 22821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2572573-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000317710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020570.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82739.
GeneTreeiENSGT00510000046634.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiA5PJS2.
KOiK12343.
OMAiEYISAAN.
OrthoDBiEOG75QR56.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJS2-1 [UniParc]FASTAAdd to Basket

« Hide

MELAERFLLD ALAYLECALG VVCYVLLKLV GSPYGRYASS GSAFGLPARA    50
AWTVQELPSL ALPLLACAGA GAPAERLNRW PNCILLAMFL VHYAQRSLVF 100
PFLIRGGKPM PLYAFLLAFI FCTYNGYLQS RYLSQYAVYA DDWLSDPRFL 150
TGSALWLIGM LINIHSDHVL RNLRKPGETG YKIPRGGLFE YISAANYFGE 200
VVEWCGYALA SWSIQGWAFA VFTFCVLFTR AQQHHKWYHE KFEDYPKFRK 250
IMIPFLV 257
Length:257
Mass (Da):29,186
Last modified:July 10, 2007 - v1
Checksum:i2A49937DFB45FFB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142219 mRNA. Translation: AAI42220.1.
RefSeqiNP_001092607.1. NM_001099137.1.
XP_005221727.1. XM_005221670.1.
UniGeneiBt.27694.

Genome annotation databases

EnsembliENSBTAT00000020570; ENSBTAP00000020570; ENSBTAG00000015478.
GeneIDi614612.
KEGGibta:614612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142219 mRNA. Translation: AAI42220.1 .
RefSeqi NP_001092607.1. NM_001099137.1.
XP_005221727.1. XM_005221670.1.
UniGenei Bt.27694.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000020570.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000020570 ; ENSBTAP00000020570 ; ENSBTAG00000015478 .
GeneIDi 614612.
KEGGi bta:614612.

Organism-specific databases

CTDi 6715.

Phylogenomic databases

eggNOGi NOG82739.
GeneTreei ENSGT00510000046634.
HOGENOMi HOG000050133.
HOVERGENi HBG003402.
InParanoidi A5PJS2.
KOi K12343.
OMAi EYISAAN.
OrthoDBi EOG75QR56.
TreeFami TF314668.

Enzyme and pathway databases

Reactomei REACT_212422. Androgen biosynthesis.

Miscellaneous databases

NextBioi 20899190.

Family and domain databases

InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiS5A1_BOVIN
AccessioniPrimary (citable) accession number: A5PJS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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