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A5PJS2 (S5A1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1

EC=1.3.1.22
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name=S5AR 1
Gene names
Name:SRD5A1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.

Catalytic activity

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

Subcellular location

Microsome membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2572573-oxo-5-alpha-steroid 4-dehydrogenase 1
PRO_0000317710

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane208 – 22821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5PJS2 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 2A49937DFB45FFB0

FASTA25729,186
        10         20         30         40         50         60 
MELAERFLLD ALAYLECALG VVCYVLLKLV GSPYGRYASS GSAFGLPARA AWTVQELPSL 

        70         80         90        100        110        120 
ALPLLACAGA GAPAERLNRW PNCILLAMFL VHYAQRSLVF PFLIRGGKPM PLYAFLLAFI 

       130        140        150        160        170        180 
FCTYNGYLQS RYLSQYAVYA DDWLSDPRFL TGSALWLIGM LINIHSDHVL RNLRKPGETG 

       190        200        210        220        230        240 
YKIPRGGLFE YISAANYFGE VVEWCGYALA SWSIQGWAFA VFTFCVLFTR AQQHHKWYHE 

       250 
KFEDYPKFRK IMIPFLV 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC142219 mRNA. Translation: AAI42220.1.
RefSeqNP_001092607.1. NM_001099137.1.
XP_005221727.1. XM_005221670.1.
UniGeneBt.27694.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000020570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000020570; ENSBTAP00000020570; ENSBTAG00000015478.
GeneID614612.
KEGGbta:614612.

Organism-specific databases

CTD6715.

Phylogenomic databases

eggNOGNOG82739.
GeneTreeENSGT00510000046634.
HOGENOMHOG000050133.
HOVERGENHBG003402.
InParanoidA5PJS2.
KOK12343.
OMAEYISAAN.
OrthoDBEOG75QR56.
TreeFamTF314668.

Family and domain databases

InterProIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20899190.

Entry information

Entry nameS5A1_BOVIN
AccessionPrimary (citable) accession number: A5PJS2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families