Reviewed, UniProtKB/Swiss-Prot A5PJS2 (S5A1_BOVIN)

Names and origin

Protein names

Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 1
    SR type 1

Gene names

Name:

SRD5A1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.
Catalytic activity	A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.
Subcellular location	Microsome membrane; Multi-pass membrane proteinBy similarity. Endoplasmic reticulum membrane; Multi-pass membrane proteinPotential.
Sequence similarities	Belongs to the steroid 5-alpha reductase family.

Ontologies

Keywords
Biological process	Differentiation Sexual differentiation
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Transmembrane
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sex determination Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxo-5-alpha-steroid 4-dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	3-oxo-5-alpha-steroid 4-dehydrogenase 1		PRO_0000317710
Regions
	Transmembrane	7 – 27	21	Potential
	Transmembrane	50 – 70	21	Potential
	Transmembrane	84 – 104	21	Potential
	Transmembrane	109 – 129	21	Potential
	Transmembrane	149 – 169	21	Potential
	Transmembrane	208 – 228	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	A5PJS2-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 2A49937DFB45FFB0	FASTA	257	29,186
	10 20 30 40 50 60 MELAERFLLD ALAYLECALG VVCYVLLKLV GSPYGRYASS GSAFGLPARA AWTVQELPSL 70 80 90 100 110 120 ALPLLACAGA GAPAERLNRW PNCILLAMFL VHYAQRSLVF PFLIRGGKPM PLYAFLLAFI 130 140 150 160 170 180 FCTYNGYLQS RYLSQYAVYA DDWLSDPRFL TGSALWLIGM LINIHSDHVL RNLRKPGETG 190 200 210 220 230 240 YKIPRGGLFE YISAANYFGE VVEWCGYALA SWSIQGWAFA VFTFCVLFTR AQQHHKWYHE 250 KFEDYPKFRK IMIPFLV

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC142219 mRNA. Translation: AAI42220.1.
RefSeq	NP_001092607.1.
UniGene	Bt.27694
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000015478. Bos taurus. [Contig view]
GeneID	614612.
KEGG	bta:614612.
Family and domain databases
InterPro	IPR016636. 3-oxo-5-alpha-steroid_4-DH. IPR001104. 3-oxo-5_a-steroid_4-DHase_C. [Graphical view]
Pfam	PF02544. Steroid_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITE	PS50244. S5A_REDUCTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

S5A1_BOVIN

Accession

Primary (citable) accession number: A5PJS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 10, 2007
Last modified:	November 25, 2008
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)