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A5PJS2

- S5A1_BOVIN

UniProt

A5PJS2 - S5A1_BOVIN

Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

SRD5A1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology By similarity.By similarity

    Catalytic activityi

    A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

    GO - Molecular functioni

    1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
    2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. androgen biosynthetic process Source: Ensembl
    2. cell differentiation Source: UniProtKB-KW
    3. sex differentiation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Differentiation, Sexual differentiation

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_212422. Androgen biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
    Alternative name(s):
    SR type 1
    Steroid 5-alpha-reductase 1
    Short name:
    S5AR 1
    Gene namesi
    Name:SRD5A1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 20

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2572573-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000317710Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000020570.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the steroid 5-alpha reductase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82739.
    GeneTreeiENSGT00510000046634.
    HOGENOMiHOG000050133.
    HOVERGENiHBG003402.
    InParanoidiA5PJS2.
    KOiK12343.
    OMAiEYISAAN.
    OrthoDBiEOG75QR56.
    TreeFamiTF314668.

    Family and domain databases

    InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5PJS2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELAERFLLD ALAYLECALG VVCYVLLKLV GSPYGRYASS GSAFGLPARA    50
    AWTVQELPSL ALPLLACAGA GAPAERLNRW PNCILLAMFL VHYAQRSLVF 100
    PFLIRGGKPM PLYAFLLAFI FCTYNGYLQS RYLSQYAVYA DDWLSDPRFL 150
    TGSALWLIGM LINIHSDHVL RNLRKPGETG YKIPRGGLFE YISAANYFGE 200
    VVEWCGYALA SWSIQGWAFA VFTFCVLFTR AQQHHKWYHE KFEDYPKFRK 250
    IMIPFLV 257
    Length:257
    Mass (Da):29,186
    Last modified:July 10, 2007 - v1
    Checksum:i2A49937DFB45FFB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142219 mRNA. Translation: AAI42220.1.
    RefSeqiNP_001092607.1. NM_001099137.1.
    XP_005221727.1. XM_005221670.1.
    UniGeneiBt.27694.

    Genome annotation databases

    EnsembliENSBTAT00000020570; ENSBTAP00000020570; ENSBTAG00000015478.
    GeneIDi614612.
    KEGGibta:614612.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142219 mRNA. Translation: AAI42220.1 .
    RefSeqi NP_001092607.1. NM_001099137.1.
    XP_005221727.1. XM_005221670.1.
    UniGenei Bt.27694.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000020570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000020570 ; ENSBTAP00000020570 ; ENSBTAG00000015478 .
    GeneIDi 614612.
    KEGGi bta:614612.

    Organism-specific databases

    CTDi 6715.

    Phylogenomic databases

    eggNOGi NOG82739.
    GeneTreei ENSGT00510000046634.
    HOGENOMi HOG000050133.
    HOVERGENi HBG003402.
    InParanoidi A5PJS2.
    KOi K12343.
    OMAi EYISAAN.
    OrthoDBi EOG75QR56.
    TreeFami TF314668.

    Enzyme and pathway databases

    Reactomei REACT_212422. Androgen biosynthesis.

    Miscellaneous databases

    NextBioi 20899190.

    Family and domain databases

    InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.

    Entry informationi

    Entry nameiS5A1_BOVIN
    AccessioniPrimary (citable) accession number: A5PJS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3