Reviewed,
UniProtKB/Swiss-Prot A5PJR4 (PURA1_BOVIN)
Last modified
September 1, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Adenylosuccinate synthetase isozyme 1 Short name=AMPSase 1 Short name=AdSS 1 EC=6.3.4.4 Alternative name(s): IMP--aspartate ligase 1 | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 457 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays an important role in the de novo pathway of purine nucleotide biosynthesis By similarity. |
| Catalytic activity | GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. |
| Pathway | Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the adenylosuccinate synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | GTP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Ligase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylosuccinate synthase activityInferred from electronic annotation. Source: EC magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 457 | 457 | Adenylosuccinate synthetase isozyme 1 | PRO_0000321960 | |||||
Regions | |||||||||
| Nucleotide binding | 42 – 48 | 7 | GTP Potential | ||||||
Sites | |||||||||
| Active site | 174 | 1 | By similarity | ||||||
| Active site | 181 | 1 | By similarity | ||||||
| Metal binding | 43 | 1 | Magnesium By similarity | ||||||
| Metal binding | 70 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 388 | 1 | Phosphotyrosine By similarity | ||||||
Sequences
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References
| [1] | NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle. |
Cross-references
Sequence databases | |
|---|---|
| BC142211 mRNA. Translation: AAI42212.1. | |
| IPI | IPI00707722. |
| RefSeq | NP_001092662.1. |
| UniGene | Bt.16782 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5PJR4. |
Genome annotation databases | |
| Ensembl | ENSBTAT00000044296; ENSBTAP00000041803; ENSBTAG00000017616; Bos taurus. [Genome view] |
| GeneID | 784089. |
| KEGG | bta:784089. |
Organism-specific databases | |
| CTD | 784089. |
Enzyme and pathway databases | |
| BRENDA | 6.3.4.4. 251. |
Family and domain databases | |
| InterPro | IPR018220. Adenylosuccinate_synthase_AS. IPR001114. Adenylosuccinate_synthetase. [Graphical view] |
| PANTHER | PTHR11846. Asucc_synthtase. 1 hit. |
| Pfam | PF00709. Adenylsucc_synt. 1 hit. [Graphical view] |
| ProDom | PD001188. Asucc_synthtase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00184. purA. 1 hit. |
| PROSITE | PS01266. ADENYLOSUCCIN_SYN_1. 1 hit. PS00513. ADENYLOSUCCIN_SYN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PURA1_BOVIN | ||||||||
| Accession | Primary (citable) accession number: A5PJR4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


