Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thyroid transcription factor 1-associated protein 26

Gene

CCDC59

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-5683826. Surfactant metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid transcription factor 1-associated protein 26
Short name:
TTF-1-associated protein 26
Alternative name(s):
Coiled-coil domain-containing protein 59
Gene namesi
Name:CCDC59
Synonyms:TAP26
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002989401 – 241Thyroid transcription factor 1-associated protein 26Add BLAST241

Proteomic databases

PaxDbiA5PJN1.
PRIDEiA5PJN1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000036282.

Interactioni

Subunit structurei

Interacts with NKX2-1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047439.

Family & Domainsi

Sequence similaritiesi

Belongs to the TAP26 family.Curated

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiA5PJN1.
OMAiKIQQNYK.
OrthoDBiEOG091G0QX3.
TreeFamiTF324429.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.

Sequencei

Sequence statusi: Complete.

A5PJN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVWPAARG RTGGLGTRGR VSPVEFRNKN VKRKTWRPNH LQAFAGSVRE
60 70 80 90 100
GQGFAFRRKL KIQQTYKKLL RREKKSQTPS ESPFTDWYPD HLKHLYLAEE
110 120 130 140 150
ERLKKQLRKA DQPLSEEQVD QPLPEDQGSS DQALSEERCS IEQPQPAEPC
160 170 180 190 200
SIRINSINIP KKNKKKTSNQ KAQEEYEQIQ AKRAAKKQEF ERRKQEREEA
210 220 230 240
QRLYKKKKME VFKILSKKTK KGQPNLNLQM EYLLKKIQEN N
Length:241
Mass (Da):28,339
Last modified:July 10, 2007 - v1
Checksum:iB5ED36EA5E1BC995
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163N → K in AAI10034 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110033 mRNA. Translation: AAI10034.1.
BC142178 mRNA. Translation: AAI42179.1.
RefSeqiNP_001092860.1. NM_001099390.1.
UniGeneiBt.103379.

Genome annotation databases

EnsembliENSBTAT00000050784; ENSBTAP00000047439; ENSBTAG00000036282.
GeneIDi615189.
KEGGibta:615189.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC110033 mRNA. Translation: AAI10034.1.
BC142178 mRNA. Translation: AAI42179.1.
RefSeqiNP_001092860.1. NM_001099390.1.
UniGeneiBt.103379.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047439.

Proteomic databases

PaxDbiA5PJN1.
PRIDEiA5PJN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000050784; ENSBTAP00000047439; ENSBTAG00000036282.
GeneIDi615189.
KEGGibta:615189.

Organism-specific databases

CTDi29080.

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiA5PJN1.
OMAiKIQQNYK.
OrthoDBiEOG091G0QX3.
TreeFamiTF324429.

Enzyme and pathway databases

ReactomeiR-BTA-5683826. Surfactant metabolism.

Gene expression databases

BgeeiENSBTAG00000036282.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.
ProtoNetiSearch...

Entry informationi

Entry nameiTAP26_BOVIN
AccessioniPrimary (citable) accession number: A5PJN1
Secondary accession number(s): Q32KL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.