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Protein

Leucine-rich repeat-containing protein 14

Gene

LRRC14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 14By similarity
Gene namesi
Name:LRRC14By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003436801 – 493Leucine-rich repeat-containing protein 14Add BLAST493

Proteomic databases

PaxDbiA5PJJ5.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004969.

Interactioni

Subunit structurei

Interacts with IKBKB; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation. Interacts with CHUK.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006542.

Structurei

3D structure databases

ProteinModelPortaliA5PJJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 146LRR 1; degenerateBy similarityAdd BLAST36
Repeati194 – 218LRR 2; degenerateBy similarityAdd BLAST25
Repeati219 – 246LRR 3; degenerateBy similarityAdd BLAST28
Repeati247 – 282LRR 4; degenerateBy similarityAdd BLAST36
Repeati283 – 307LRR 5By similarityAdd BLAST25
Repeati308 – 339LRR 6By similarityAdd BLAST32
Repeati340 – 360LRR 7By similarityAdd BLAST21
Repeati364 – 391LRR 8By similarityAdd BLAST28
Repeati392 – 416LRR 9By similarityAdd BLAST25

Sequence similaritiesi

Belongs to the PRAME family. LRRC14 subfamily.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIBA. Eukaryota.
ENOG4111FCX. LUCA.
GeneTreeiENSGT00760000119028.
HOGENOMiHOG000113363.
HOVERGENiHBG052342.
InParanoidiA5PJJ5.
OMAiPILTRCT.
OrthoDBiEOG091G05TB.
TreeFamiTF332708.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR026292. LRRC14.
PANTHERiPTHR14224:SF9. PTHR14224:SF9. 1 hit.
PfamiView protein in Pfam
PF13516. LRR_6. 2 hits.

Sequencei

Sequence statusi: Complete.

A5PJJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHTLVFLSTR QVLQCQSAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL
60 70 80 90 100
VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTPE
110 120 130 140 150
TEPGTQPLCR KHTLRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIEQ
160 170 180 190 200
QQGRTAEPGQ APVPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL
210 220 230 240 250
RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL
260 270 280 290 300
ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL
310 320 330 340 350
DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSSHAVHLKK LDLSGNDLSG
360 370 380 390 400
SQLEPFQGLL QAAAATLLHL ELTECQLADT QLLATLPVLT RCASLRYLGL
410 420 430 440 450
YGNPLSVAGL RELLRDSVVQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA
460 470 480 490
SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
Length:493
Mass (Da):54,918
Last modified:July 10, 2007 - v1
Checksum:i9DA2857016814323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142136 mRNA. Translation: AAI42137.1.
RefSeqiNP_001095849.1. NM_001102379.1.
XP_015329847.1. XM_015474361.1.
XP_015329848.1. XM_015474362.1.
XP_015329849.1. XM_015474363.1.
UniGeneiBt.100306.
Bt.27389.

Genome annotation databases

EnsembliENSBTAT00000006542; ENSBTAP00000006542; ENSBTAG00000004969.
GeneIDi539952.
KEGGibta:539952.

Similar proteinsi

Entry informationi

Entry nameiLRC14_BOVIN
AccessioniPrimary (citable) accession number: A5PJJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 10, 2007
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families