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Protein

Translation initiation factor eIF-2B subunit gamma

Gene

EIF2B3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit gamma
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit gamma
Gene namesi
Name:EIF2B3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003173311 – 452Translation initiation factor eIF-2B subunit gammaAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei261PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiA5PJI7.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Structurei

3D structure databases

ProteinModelPortaliA5PJI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000230731.
HOVERGENiHBG051461.
InParanoidiA5PJI7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005835. NTP_transferase_dom.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF00483. NTP_transferase. 1 hit.
SUPFAMiSSF53448. SSF53448. 4 hits.

Sequencei

Sequence statusi: Complete.

A5PJI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFQAVVMAV GGGSRMTDLT SSIPKPLLPV GNKPLIWYPL NLLERVGFEE
60 70 80 90 100
VIVITTKDVQ KALCADFNKM KMKLDIVCIP DEADMGTADS LRHIYQKLKT
110 120 130 140 150
DVLVLSCDLI TDVALHEVVD LFRAHDASLA MLMRKGQESL EPVPGQKGKK
160 170 180 190 200
KAVEQRDFVG VDSTGKRLLF MANEADLDEE LIIKGSILQK HPRIRFHTGL
210 220 230 240 250
VDAHLYCLKK YVVDFLMENK SITSIRSELI PYLVRKQFSS ASSQQGQEEK
260 270 280 290 300
EEDLKKKELK SLDIYSFIKE ANTLTLAPYD TCWNACRGDS WEGLSRSQVR
310 320 330 340 350
CYVHIMKEGL CSRVSTLGLY MEANRQVSKL LPVICPEESL IHSSAQIVSK
360 370 380 390 400
HMVGADSLIG PDTQVGEKSS IKHSVIGSSC VIRDRVTVTN CLLMNSVTVE
410 420 430 440 450
EGSNIQSSII CNDAVIEKGA DIKNCLIGSG QRIEAKAKRV NVIVGNDQFL

EI
Length:452
Mass (Da):50,218
Last modified:July 10, 2007 - v1
Checksum:iA58454090E7F0623
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142127 mRNA. Translation: AAI42128.1.
UniGeneiBt.10192.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEI2BG_BOVIN
AccessioniPrimary (citable) accession number: A5PJI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 10, 2007
Last modified: April 12, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families