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Protein

Uridine phosphorylase

Gene

UPP1

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes uracil from uridine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine phosphorylase (UPP1), Uridine phosphorylase (UPP2), Uridine phosphorylase (UPP1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes uracil from uridine (phosphorylase route), the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine phosphorylaseUniRule annotation (EC:2.4.2.3UniRule annotation)
Gene namesi
Name:UPP1Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiA5PJH9.
PRIDEiA5PJH9.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011088.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KU4X-ray2.10A/B/C/D1-309[»]
3KUKX-ray2.78A/B1-309[»]
3KVRX-ray2.60A/B1-309[»]
3KVYX-ray2.30A/B1-309[»]
ProteinModelPortaliA5PJH9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5PJH9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 302249PNP_UDP_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3728. Eukaryota.
COG2820. LUCA.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
KOiK00757.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTAAETEK PEDHNDLVQL CNPHIAAMKE DILYHFSLST STHDFPAMFG
60 70 80 90 100
DVKFVCVGGS PSRMKAFIKY VAMELGFAHP GADYPNICEG TDRYAMFKVG
110 120 130 140 150
PVLSVSHGMG VPSIAIMLHE LIKLLYHAHC SGVTLIRIGT SGGIGLEPGS
160 170 180 190 200
VVITRQAVDP CFKPEFEQIV LGKREVRNTD LDEQLVQELA RCSAELGEFP
210 220 230 240 250
TVVGNTMCTL DFYEGQGRLD GALCSYTEKD KQDYLRAAYA AGIRNIEMEA
260 270 280 290 300
SVFAAMCNAC GLRAAVVCVT LLNRLEGDQI SSPHDVLAEY QQRPQRLVGQ

FIKKRLMQA
Length:309
Mass (Da):33,885
Last modified:July 10, 2007 - v1
Checksum:iBA932CE590160C0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142118 mRNA. Translation: AAI42119.1.
RefSeqiNP_001092446.1. NM_001098976.2.
UniGeneiBt.20327.

Genome annotation databases

GeneIDi515029.
KEGGibta:515029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142118 mRNA. Translation: AAI42119.1.
RefSeqiNP_001092446.1. NM_001098976.2.
UniGeneiBt.20327.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KU4X-ray2.10A/B/C/D1-309[»]
3KUKX-ray2.78A/B1-309[»]
3KVRX-ray2.60A/B1-309[»]
3KVYX-ray2.30A/B1-309[»]
ProteinModelPortaliA5PJH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011088.

Proteomic databases

PaxDbiA5PJH9.
PRIDEiA5PJH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi515029.
KEGGibta:515029.

Organism-specific databases

CTDi7378.

Phylogenomic databases

eggNOGiKOG3728. Eukaryota.
COG2820. LUCA.
HOGENOMiHOG000231747.
HOVERGENiHBG047725.
KOiK00757.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00633.

Miscellaneous databases

EvolutionaryTraceiA5PJH9.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR018017. Nucleoside_phosphorylase.
IPR018016. Nucleoside_phosphorylase_CS.
IPR000845. Nucleoside_phosphorylase_d.
IPR010059. Uridine_phosphorylase_euk.
[Graphical view]
PANTHERiPTHR21234. PTHR21234. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01719. euk_UDPppase. 1 hit.
PROSITEiPS01232. PNP_UDP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HerefordImported.
    Tissue: ThymusImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).

Entry informationi

Entry nameiA5PJH9_BOVIN
AccessioniPrimary (citable) accession number: A5PJH9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.