Reviewed, UniProtKB/Swiss-Prot A5PJG7 (CCHL_BOVIN)

Names and origin

Protein names

Recommended name:
    Cytochrome c-type heme lyase
      Short name=CCHL
    EC=4.4.1.17
Alternative name(s):
    Holocytochrome c-type synthase

Gene names

Name:

HCCS

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Links covalently the heme group to the apoprotein of cytochrome c By similarity.
Catalytic activity	Holocytochrome c = apocytochrome c + heme.
Subcellular location	Mitochondrion inner membrane Potential.
Sequence similarities	Belongs to the cytochrome c-type heme lyase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Lyase
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holocytochrome-c synthase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Cytochrome c-type heme lyase		PRO_0000331125
Regions
	Repeat	31 – 36	6	HRM 1
	Repeat	41 – 46	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	A5PJG7-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 09364E710C8BF993	FASTA	275	31,069
	10 20 30 40 50 60 MGLSASAPAA STVQTSTPAA SDHQTAAPTS GCPMHEGKVK GCPVSAEPSD STCGSKTNSV 70 80 90 100 110 120 PAHQERAYEY VQCPITGAKA ANKENLDPSN LMPPPNQTPA PDQPFPLSTV REESSIPRAD 130 140 150 160 170 180 SDKKWVYPSE QMFWNAMLRK GWKWKDEDIS QKDMYNIIRI HNQNNEQAWK EILKWEALHA 190 200 210 220 230 240 AECPCGPSLI RFGGKAKEYS PRARIRSWMG YELPFDRHDW IINRCGTEVR YVIDYYDGGE 250 260 270 VNQDYQFTIL DVRPALDSLS AVWDRMKVAW WRWTS

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC142105 mRNA. Translation: AAI42106.1.
IPI	IPI00841029.
RefSeq	NP_001092356.1.
UniGene	Bt.26718
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000016072; ENSBTAP00000016072; ENSBTAG00000012113; Bos taurus. [Genome view]
GeneID	506250.
KEGG	bta:506250.
Organism-specific databases
CTD	506250.
Phylogenomic databases
OMA	WKDDDIS.
Family and domain databases
InterPro	IPR000511. Cyt_C/C1_haem_lyase. [Graphical view]
PANTHER	PTHR12743. Cyto_heme_lyase. 1 hit.
Pfam	PF01265. Cyto_heme_lyase. 1 hit. [Graphical view]
PROSITE	PS00821. CYTO_HEME_LYASE_1. 1 hit. PS00822. CYTO_HEME_LYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCHL_BOVIN

Accession

Primary (citable) accession number: A5PJG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)