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Protein

Cytochrome c-type heme lyase

Gene

HCCS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Links covalently the heme group to the apoprotein of cytochrome c.By similarity

Catalytic activityi

Holocytochrome c = apocytochrome c + heme.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type heme lyase (EC:4.4.1.17)
Short name:
CCHL
Alternative name(s):
Holocytochrome c-type synthase
Gene namesi
Name:HCCS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

  • Mitochondrion inner membrane Curated
  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003311252 – 275Cytochrome c-type heme lyaseAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiA5PJG7.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012113.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016072.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 36HRM 16
Repeati41 – 46HRM 26

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3996. Eukaryota.
ENOG410YAUW. LUCA.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiA5PJG7.
KOiK01764.
OMAiMRWKYEL.
OrthoDBiEOG091G0JYQ.
TreeFamiTF105185.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PJG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSASAPAA STVQTSTPAA SDHQTAAPTS GCPMHEGKVK GCPVSAEPSD
60 70 80 90 100
STCGSKTNSV PAHQERAYEY VQCPITGAKA ANKENLDPSN LMPPPNQTPA
110 120 130 140 150
PDQPFPLSTV REESSIPRAD SDKKWVYPSE QMFWNAMLRK GWKWKDEDIS
160 170 180 190 200
QKDMYNIIRI HNQNNEQAWK EILKWEALHA AECPCGPSLI RFGGKAKEYS
210 220 230 240 250
PRARIRSWMG YELPFDRHDW IINRCGTEVR YVIDYYDGGE VNQDYQFTIL
260 270
DVRPALDSLS AVWDRMKVAW WRWTS
Length:275
Mass (Da):31,069
Last modified:July 10, 2007 - v1
Checksum:i09364E710C8BF993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142105 mRNA. Translation: AAI42106.1.
RefSeqiNP_001092356.1. NM_001098886.1.
UniGeneiBt.26718.

Genome annotation databases

EnsembliENSBTAT00000016072; ENSBTAP00000016072; ENSBTAG00000012113.
GeneIDi506250.
KEGGibta:506250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142105 mRNA. Translation: AAI42106.1.
RefSeqiNP_001092356.1. NM_001098886.1.
UniGeneiBt.26718.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016072.

Proteomic databases

PaxDbiA5PJG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016072; ENSBTAP00000016072; ENSBTAG00000012113.
GeneIDi506250.
KEGGibta:506250.

Organism-specific databases

CTDi3052.

Phylogenomic databases

eggNOGiKOG3996. Eukaryota.
ENOG410YAUW. LUCA.
GeneTreeiENSGT00390000004175.
HOGENOMiHOG000170352.
HOVERGENiHBG001566.
InParanoidiA5PJG7.
KOiK01764.
OMAiMRWKYEL.
OrthoDBiEOG091G0JYQ.
TreeFamiTF105185.

Gene expression databases

BgeeiENSBTAG00000012113.

Family and domain databases

InterProiIPR000511. Cyt_C/C1_haem_lyase.
[Graphical view]
PANTHERiPTHR12743. PTHR12743. 1 hit.
PfamiPF01265. Cyto_heme_lyase. 1 hit.
[Graphical view]
PROSITEiPS00821. CYTO_HEME_LYASE_1. 1 hit.
PS00822. CYTO_HEME_LYASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCHL_BOVIN
AccessioniPrimary (citable) accession number: A5PJG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.