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Protein

Coordinator of PRMT5 and differentiation stimulator

Gene

COPRS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Coordinator of PRMT5 and differentiation stimulator
Alternative name(s):
Cooperator of PRMT5
Gene namesi
Name:COPRS
Synonyms:COPR5
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Coordinator of PRMT5 and differentiation stimulatorPRO_0000336076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei66 – 661PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA5PJD3.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001885.

Interactioni

Subunit structurei

Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3. Interacts with CBFB. Found in a complex with PRMT5, RUNX1 and CBFB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002453.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J4CS. Eukaryota.
ENOG4111D7J. LUCA.
GeneTreeiENSGT00390000007384.
HOGENOMiHOG000111893.
InParanoidiA5PJD3.
OMAiDLNTWEL.
OrthoDBiEOG091G0W9H.
TreeFamiTF338109.

Family and domain databases

InterProiIPR029289. COPR5.
[Graphical view]
PfamiPF15340. COPR5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPPTAGAQS LGAAEQPRGL QLPSGREAPP SPGTAFAPAD HSSQEKATEN
60 70 80 90 100
ATDRLANGAQ SIPHDSPAHG EGTHCEEEGF AEDDEDSDGE PSPWELSEGM
110 120 130 140 150
SGCLPKEQAG DLFHEDWDLE LKADQGNPYD ADDIQGCLSQ EVRPWVCCAP
160 170 180
QGDMIYDPSW HHPPPLIPHY SKMVFETGQF DDAED
Length:185
Mass (Da):19,950
Last modified:July 10, 2007 - v1
Checksum:i04D77EB1D63B3B24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142058 mRNA. Translation: AAI42059.1.
RefSeqiNP_001092364.1. NM_001098894.2.
XP_010814057.1. XM_010815755.2.
UniGeneiBt.33531.

Genome annotation databases

EnsembliENSBTAT00000002453; ENSBTAP00000002453; ENSBTAG00000001885.
GeneIDi506999.
KEGGibta:506999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142058 mRNA. Translation: AAI42059.1.
RefSeqiNP_001092364.1. NM_001098894.2.
XP_010814057.1. XM_010815755.2.
UniGeneiBt.33531.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000002453.

Proteomic databases

PaxDbiA5PJD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000002453; ENSBTAP00000002453; ENSBTAG00000001885.
GeneIDi506999.
KEGGibta:506999.

Organism-specific databases

CTDi55352.

Phylogenomic databases

eggNOGiENOG410J4CS. Eukaryota.
ENOG4111D7J. LUCA.
GeneTreeiENSGT00390000007384.
HOGENOMiHOG000111893.
InParanoidiA5PJD3.
OMAiDLNTWEL.
OrthoDBiEOG091G0W9H.
TreeFamiTF338109.

Enzyme and pathway databases

ReactomeiR-BTA-3214858. RMTs methylate histone arginines.

Gene expression databases

BgeeiENSBTAG00000001885.

Family and domain databases

InterProiIPR029289. COPR5.
[Graphical view]
PfamiPF15340. COPR5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPRS_BOVIN
AccessioniPrimary (citable) accession number: A5PJD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.