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A5PJC4

- UB2L6_BOVIN

UniProt

A5PJC4 - UB2L6_BOVIN

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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

UBE2L6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: Ensembl

GO - Biological processi

  1. ISG15-protein conjugation Source: Ensembl
  2. modification-dependent protein catabolic process Source: Ensembl
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_211149. Negative regulators of RIG-I/MDA5 signaling.
REACT_215264. ISG15 antiviral mechanism.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:UBE2L6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375220Add
BLAST

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017267.

Structurei

3D structure databases

ProteinModelPortaliA5PJC4.
SMRiA5PJC4. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiA5PJC4.
KOiK04553.
OMAiPEKPPYN.
OrthoDBiEOG7GXPD8.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJC4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTASKRVAKE LEDLQKELPK YLRNLCSEED NVLVWHALLL PERPPYNLKA
60 70 80 90 100
FRLCISFPRE YPFQPPTVKF TTRIYHPNVD RDGRVCLPII SKKNWKASTR
110 120 130 140 150
TCQVLEALNM LVNQPEPGQP VRLELAEQLT QDPELFDQMA QEFTLQFGVD

RPS
Length:153
Mass (Da):17,825
Last modified:July 10, 2007 - v1
Checksum:i9FE5AD0B75E81BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142048 mRNA. Translation: AAI42049.1.
RefSeqiNP_001092387.1. NM_001098917.1.
UniGeneiBt.10807.

Genome annotation databases

EnsembliENSBTAT00000017267; ENSBTAP00000017267; ENSBTAG00000012989.
GeneIDi509471.
KEGGibta:509471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142048 mRNA. Translation: AAI42049.1 .
RefSeqi NP_001092387.1. NM_001098917.1.
UniGenei Bt.10807.

3D structure databases

ProteinModelPortali A5PJC4.
SMRi A5PJC4. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017267 ; ENSBTAP00000017267 ; ENSBTAG00000012989 .
GeneIDi 509471.
KEGGi bta:509471.

Organism-specific databases

CTDi 9246.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00760000119012.
HOGENOMi HOG000233455.
InParanoidi A5PJC4.
KOi K04553.
OMAi PEKPPYN.
OrthoDBi EOG7GXPD8.
TreeFami TF313043.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_211149. Negative regulators of RIG-I/MDA5 signaling.
REACT_215264. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi 20868980.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiUB2L6_BOVIN
AccessioniPrimary (citable) accession number: A5PJC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3