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A5PJC4

- UB2L6_BOVIN

UniProt

A5PJC4 - UB2L6_BOVIN

Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

UBE2L6

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ISG15 ligase activity Source: Ensembl

    GO - Biological processi

    1. ISG15-protein conjugation Source: Ensembl
    2. modification-dependent protein catabolic process Source: Ensembl
    3. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_211149. Negative regulators of RIG-I/MDA5 signaling.
    REACT_215264. ISG15 antiviral mechanism.
    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein L6
    Ubiquitin-protein ligase L6
    Gene namesi
    Name:UBE2L6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 15

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375220Add
    BLAST

    Post-translational modificationi

    ISGylated.By similarity

    Keywords - PTMi

    Ubl conjugation

    Interactioni

    Subunit structurei

    Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000017267.

    Structurei

    3D structure databases

    ProteinModelPortaliA5PJC4.
    SMRiA5PJC4. Positions 3-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00740000115416.
    HOGENOMiHOG000233455.
    InParanoidiA5PJC4.
    KOiK04553.
    OMAiPEKPPYN.
    OrthoDBiEOG7GXPD8.
    TreeFamiTF313043.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5PJC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTASKRVAKE LEDLQKELPK YLRNLCSEED NVLVWHALLL PERPPYNLKA    50
    FRLCISFPRE YPFQPPTVKF TTRIYHPNVD RDGRVCLPII SKKNWKASTR 100
    TCQVLEALNM LVNQPEPGQP VRLELAEQLT QDPELFDQMA QEFTLQFGVD 150
    RPS 153
    Length:153
    Mass (Da):17,825
    Last modified:July 10, 2007 - v1
    Checksum:i9FE5AD0B75E81BC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142048 mRNA. Translation: AAI42049.1.
    RefSeqiNP_001092387.1. NM_001098917.1.
    UniGeneiBt.10807.

    Genome annotation databases

    EnsembliENSBTAT00000017267; ENSBTAP00000017267; ENSBTAG00000012989.
    GeneIDi509471.
    KEGGibta:509471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142048 mRNA. Translation: AAI42049.1 .
    RefSeqi NP_001092387.1. NM_001098917.1.
    UniGenei Bt.10807.

    3D structure databases

    ProteinModelPortali A5PJC4.
    SMRi A5PJC4. Positions 3-152.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000017267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017267 ; ENSBTAP00000017267 ; ENSBTAG00000012989 .
    GeneIDi 509471.
    KEGGi bta:509471.

    Organism-specific databases

    CTDi 9246.

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00740000115416.
    HOGENOMi HOG000233455.
    InParanoidi A5PJC4.
    KOi K04553.
    OMAi PEKPPYN.
    OrthoDBi EOG7GXPD8.
    TreeFami TF313043.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .
    Reactomei REACT_211149. Negative regulators of RIG-I/MDA5 signaling.
    REACT_215264. ISG15 antiviral mechanism.

    Miscellaneous databases

    NextBioi 20868980.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Ileum.

    Entry informationi

    Entry nameiUB2L6_BOVIN
    AccessioniPrimary (citable) accession number: A5PJC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3