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A5PJC4

- UB2L6_BOVIN

UniProt

A5PJC4 - UB2L6_BOVIN

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Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene
UBE2L6
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3 By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ISG15 ligase activity Source: Ensembl

GO - Biological processi

  1. ISG15-protein conjugation Source: Ensembl
  2. modification-dependent protein catabolic process Source: Ensembl
  3. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_211149. Negative regulators of RIG-I/MDA5 signaling.
REACT_215264. ISG15 antiviral mechanism.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:UBE2L6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 15

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Ubiquitin/ISG15-conjugating enzyme E2 L6PRO_0000375220Add
BLAST

Post-translational modificationi

ISGylated By similarity.

Keywords - PTMi

Ubl conjugation

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated) By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017267.

Structurei

3D structure databases

ProteinModelPortaliA5PJC4.
SMRiA5PJC4. Positions 3-152.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00740000115416.
HOGENOMiHOG000233455.
InParanoidiA5PJC4.
KOiK04553.
OMAiPEKPPYN.
OrthoDBiEOG7GXPD8.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJC4-1 [UniParc]FASTAAdd to Basket

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MTASKRVAKE LEDLQKELPK YLRNLCSEED NVLVWHALLL PERPPYNLKA    50
FRLCISFPRE YPFQPPTVKF TTRIYHPNVD RDGRVCLPII SKKNWKASTR 100
TCQVLEALNM LVNQPEPGQP VRLELAEQLT QDPELFDQMA QEFTLQFGVD 150
RPS 153
Length:153
Mass (Da):17,825
Last modified:July 10, 2007 - v1
Checksum:i9FE5AD0B75E81BC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142048 mRNA. Translation: AAI42049.1.
RefSeqiNP_001092387.1. NM_001098917.1.
UniGeneiBt.10807.

Genome annotation databases

EnsembliENSBTAT00000017267; ENSBTAP00000017267; ENSBTAG00000012989.
GeneIDi509471.
KEGGibta:509471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142048 mRNA. Translation: AAI42049.1 .
RefSeqi NP_001092387.1. NM_001098917.1.
UniGenei Bt.10807.

3D structure databases

ProteinModelPortali A5PJC4.
SMRi A5PJC4. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000017267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017267 ; ENSBTAP00000017267 ; ENSBTAG00000012989 .
GeneIDi 509471.
KEGGi bta:509471.

Organism-specific databases

CTDi 9246.

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00740000115416.
HOGENOMi HOG000233455.
InParanoidi A5PJC4.
KOi K04553.
OMAi PEKPPYN.
OrthoDBi EOG7GXPD8.
TreeFami TF313043.

Enzyme and pathway databases

UniPathwayi UPA00143 .
Reactomei REACT_211149. Negative regulators of RIG-I/MDA5 signaling.
REACT_215264. ISG15 antiviral mechanism.

Miscellaneous databases

NextBioi 20868980.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiUB2L6_BOVIN
AccessioniPrimary (citable) accession number: A5PJC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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