Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin/ISG15-conjugating enzyme E2 L6

Gene

UBE2L6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei86Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-1169408. ISG15 antiviral mechanism.
R-BTA-5656169. Termination of translesion DNA synthesis.
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme L6
Ubiquitin carrier protein L6
Ubiquitin-protein ligase L6
Gene namesi
Name:UBE2L6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003752201 – 153Ubiquitin/ISG15-conjugating enzyme E2 L6Add BLAST153

Post-translational modificationi

ISGylated.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiA5PJC4.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012989.

Interactioni

Subunit structurei

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017267.

Structurei

3D structure databases

ProteinModelPortaliA5PJC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0422. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiA5PJC4.
KOiK04553.
OMAiEKPPYNL.
OrthoDBiEOG091G0QDO.
TreeFamiTF313043.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASKRVAKE LEDLQKELPK YLRNLCSEED NVLVWHALLL PERPPYNLKA
60 70 80 90 100
FRLCISFPRE YPFQPPTVKF TTRIYHPNVD RDGRVCLPII SKKNWKASTR
110 120 130 140 150
TCQVLEALNM LVNQPEPGQP VRLELAEQLT QDPELFDQMA QEFTLQFGVD

RPS
Length:153
Mass (Da):17,825
Last modified:July 10, 2007 - v1
Checksum:i9FE5AD0B75E81BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142048 mRNA. Translation: AAI42049.1.
RefSeqiNP_001092387.1. NM_001098917.1.
UniGeneiBt.10807.

Genome annotation databases

EnsembliENSBTAT00000017267; ENSBTAP00000017267; ENSBTAG00000012989.
GeneIDi509471.
KEGGibta:509471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142048 mRNA. Translation: AAI42049.1.
RefSeqiNP_001092387.1. NM_001098917.1.
UniGeneiBt.10807.

3D structure databases

ProteinModelPortaliA5PJC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017267.

Proteomic databases

PaxDbiA5PJC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017267; ENSBTAP00000017267; ENSBTAG00000012989.
GeneIDi509471.
KEGGibta:509471.

Organism-specific databases

CTDi9246.

Phylogenomic databases

eggNOGiKOG0422. Eukaryota.
COG5078. LUCA.
GeneTreeiENSGT00760000119012.
HOGENOMiHOG000233455.
InParanoidiA5PJC4.
KOiK04553.
OMAiEKPPYNL.
OrthoDBiEOG091G0QDO.
TreeFamiTF313043.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-BTA-1169408. ISG15 antiviral mechanism.
R-BTA-5656169. Termination of translesion DNA synthesis.
R-BTA-936440. Negative regulators of RIG-I/MDA5 signaling.

Gene expression databases

BgeeiENSBTAG00000012989.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUB2L6_BOVIN
AccessioniPrimary (citable) accession number: A5PJC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: July 10, 2007
Last modified: October 5, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.