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Protein

Insulin

Gene

INS

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationSAAS annotation

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: AgBase
  • insulin receptor binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-BTA-264876. Insulin processing.
R-BTA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-74713. IRS activation.
R-BTA-74749. Signal attenuation.
R-BTA-74751. Insulin receptor signalling cascade.
R-BTA-74752. Signaling by Insulin receptor.
R-BTA-77387. Insulin receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
InsulinUniRule annotation
Gene namesi
Name:INSImported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 29

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 10581InsulinSequence analysisPRO_5007635447Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.UniRule annotationSAAS annotation

GO - Molecular functioni

  • insulin-like growth factor receptor binding Source: AgBase
  • insulin receptor binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017289.

Structurei

3D structure databases

SMRiA5PJB2. Positions 25-105.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10477IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiGFFYSPK.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5PJB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWTRLAPL LALLALWAPA PARAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKARREVEG PQVGALELAG GPGAGGLEGP PQKRGIVEQC CASVCSLYQL

ENYCN
Length:105
Mass (Da):11,256
Last modified:July 10, 2007 - v1
Checksum:iCA39293FD2F8783E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02063736 Genomic DNA. No translation available.
BC142034 mRNA. Translation: AAI42035.1.
EU518675 Genomic DNA. Translation: ACD35246.1.
RefSeqiNP_001172055.1. NM_001185126.1.
NP_776351.2. NM_173926.2.
UniGeneiBt.453.

Genome annotation databases

EnsembliENSBTAT00000017289; ENSBTAP00000017289; ENSBTAG00000013003.
GeneIDi280829.
KEGGibta:280829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02063736 Genomic DNA. No translation available.
BC142034 mRNA. Translation: AAI42035.1.
EU518675 Genomic DNA. Translation: ACD35246.1.
RefSeqiNP_001172055.1. NM_001185126.1.
NP_776351.2. NM_173926.2.
UniGeneiBt.453.

3D structure databases

SMRiA5PJB2. Positions 25-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017289; ENSBTAP00000017289; ENSBTAG00000013003.
GeneIDi280829.
KEGGibta:280829.

Organism-specific databases

CTDi3630.

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiGFFYSPK.
OrthoDBiEOG091G0H56.
TreeFamiTF332820.

Enzyme and pathway databases

ReactomeiR-BTA-264876. Insulin processing.
R-BTA-422085. Synthesis, secretion, and deacylation of Ghrelin.
R-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-74713. IRS activation.
R-BTA-74749. Signal attenuation.
R-BTA-74751. Insulin receptor signalling cascade.
R-BTA-74752. Signaling by Insulin receptor.
R-BTA-77387. Insulin receptor recycling.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5PJB2_BOVIN
AccessioniPrimary (citable) accession number: A5PJB2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.