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Protein

Adenylate kinase isoenzyme 6

Gene

AK6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391AMPUniRule annotation
Binding sitei79 – 791ATPUniRule annotation
Binding sitei105 – 1051ATPUniRule annotation
Binding sitei109 – 1091ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186ATPUniRule annotation
Nucleotide bindingi148 – 1492ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:AK6UniRule annotation
Synonyms:CINAPUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Subcellular locationi

  • Nucleusnucleoplasm UniRule annotation
  • NucleusCajal body UniRule annotation

  • Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Adenylate kinase isoenzyme 6PRO_0000314780Add
BLAST

Proteomic databases

PaxDbiA5PJA1.
PRIDEiA5PJA1.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040135.

Structurei

3D structure databases

ProteinModelPortaliA5PJA1.
SMRiA5PJA1. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 5624NMPbindUniRule annotationAdd
BLAST
Regioni108 – 11811LIDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000015930.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiDNVQCEI.
OrthoDBiEOG75XGNB.
TreeFamiTF313388.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A5PJA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPNILLTG TPGVGKTTLG KELASRSGLK YINVGDLARE GQLYDGYDEE
60 70 80 90 100
YDCPILDEDR VVDELENQMS EGGVIVDYHG CDFFPERWFH IVFVLKTDNS
110 120 130 140 150
ILYKRLENRG YNEKKLKDNI QCEIFQVLHE EALASYKEEI VHQLPSNKPE
160 170
DLEDNINQIL KWIEHWVKDH SS
Length:172
Mass (Da):19,927
Last modified:July 10, 2007 - v1
Checksum:i25C41B5B759976D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142021 mRNA. Translation: AAI42022.1.
RefSeqiNP_001099078.1. NM_001105608.2.
UniGeneiBt.52808.

Genome annotation databases

EnsembliENSBTAT00000040360; ENSBTAP00000040135; ENSBTAG00000046192.
GeneIDi102216273.
KEGGibta:102216273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142021 mRNA. Translation: AAI42022.1.
RefSeqiNP_001099078.1. NM_001105608.2.
UniGeneiBt.52808.

3D structure databases

ProteinModelPortaliA5PJA1.
SMRiA5PJA1. Positions 1-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040135.

Proteomic databases

PaxDbiA5PJA1.
PRIDEiA5PJA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000040360; ENSBTAP00000040135; ENSBTAG00000046192.
GeneIDi102216273.
KEGGibta:102216273.

Organism-specific databases

CTDi102157402.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000015930.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiDNVQCEI.
OrthoDBiEOG75XGNB.
TreeFamiTF313388.

Miscellaneous databases

NextBioi20875852.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal pons.

Entry informationi

Entry nameiKAD6_BOVIN
AccessioniPrimary (citable) accession number: A5PJA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.