Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylate kinase isoenzyme 6

Gene

AK6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39AMPUniRule annotation1
Binding sitei79ATPUniRule annotation1
Binding sitei105ATPUniRule annotation1
Binding sitei109ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18ATPUniRule annotation6
Nucleotide bindingi148 – 149ATPUniRule annotation2

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:AK6UniRule annotation
Synonyms:CINAPUniRule annotation
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:25775 AK6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147801 – 172Adenylate kinase isoenzyme 6Add BLAST172

Proteomic databases

PaxDbiA5PJA1
PRIDEiA5PJA1

Expressioni

Gene expression databases

BgeeiENSBTAG00000046192

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000040135

Structurei

3D structure databases

ProteinModelPortaliA5PJA1
SMRiA5PJA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 56NMPbindUniRule annotationAdd BLAST24
Regioni108 – 118LIDUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347 Eukaryota
COG1936 LUCA
GeneTreeiENSGT00390000015930
HOGENOMiHOG000224472
HOVERGENiHBG052207
KOiK18532
OMAiDNVQCEI
OrthoDBiEOG091G0RS8
TreeFamiTF313388

Family and domain databases

HAMAPiMF_00039 Adenylate_kinase_AK6, 1 hit
InterProiView protein in InterPro
IPR020618 Adenyl_kinase_AK6
IPR027417 P-loop_NTPase
PANTHERiPTHR12595:SF0 PTHR12595:SF0, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A5PJA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLPNILLTG TPGVGKTTLG KELASRSGLK YINVGDLARE GQLYDGYDEE
60 70 80 90 100
YDCPILDEDR VVDELENQMS EGGVIVDYHG CDFFPERWFH IVFVLKTDNS
110 120 130 140 150
ILYKRLENRG YNEKKLKDNI QCEIFQVLHE EALASYKEEI VHQLPSNKPE
160 170
DLEDNINQIL KWIEHWVKDH SS
Length:172
Mass (Da):19,927
Last modified:July 10, 2007 - v1
Checksum:i25C41B5B759976D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142021 mRNA Translation: AAI42022.1
RefSeqiNP_001099078.1, NM_001105608.2
UniGeneiBt.52808

Genome annotation databases

EnsembliENSBTAT00000040360; ENSBTAP00000040135; ENSBTAG00000046192
GeneIDi102216273
KEGGibta:102216273

Similar proteinsi

Entry informationi

Entry nameiKAD6_BOVIN
AccessioniPrimary (citable) accession number: A5PJA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health