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A5PJ93

- MZB1_BOVIN

UniProt

A5PJ93 - MZB1_BOVIN

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Protein

Marginal zone B- and B1-cell-specific protein

Gene

MZB1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation (By similarity).By similarity
Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity).By similarity

GO - Biological processi

  1. integrin activation Source: UniProtKB
  2. negative regulation of glucose import in response to insulin stimulus Source: UniProtKB
  3. positive regulation of cell proliferation Source: UniProtKB
  4. positive regulation of immunoglobulin biosynthetic process Source: UniProtKB
  5. regulation of B cell proliferation Source: UniProtKB
  6. regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name:
Plasma cell-induced resident ER protein
Short name:
pERp1
Proapoptotic caspase adapter protein
Gene namesi
Name:MZB1
Synonyms:PACAP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

Endoplasmic reticulum lumen By similarity. Secreted By similarity

GO - Cellular componenti

  1. endoplasmic reticulum chaperone complex Source: UniProtKB
  2. endoplasmic reticulum lumen Source: UniProtKB
  3. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 189173Marginal zone B- and B1-cell-specific proteinPRO_0000318739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 178By similarity
Disulfide bondi53 ↔ 171By similarity
Disulfide bondi95 ↔ 143By similarity

Post-translational modificationi

Forms an interchain disulfide bond with IgM monomers.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiA5PJ93.

Interactioni

Subunit structurei

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000047624.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 1894Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the MZB1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG74024.
GeneTreeiENSGT00390000002716.
HOGENOMiHOG000068171.
HOVERGENiHBG108230.
InParanoidiA5PJ93.
OMAiYQMWQHL.
OrthoDBiEOG7D2FFZ.
TreeFamiTF329450.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5PJ93-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MRLSLLLLLP LLGAWAIPGG FGDEASLTAT APELDDEEKF STHIPTHLRC
60 70 80 90 100
DACRAVAYQM WQHLTKAEAK LLPLDSGGRR ELSESVYTDV LDQSCSQTWQ
110 120 130 140 150
GYGVGEVDQV KRLMGPGLST GAQPSIMVMI MEGLWPTRLS KTCFHYLGEF
160 170 180
GEDQIYEAHQ QGRGTLEALL CGGPRGACSE KAPDTRTEL
Length:189
Mass (Da):20,699
Last modified:July 10, 2007 - v1
Checksum:iA8A717AC1E76DE1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142012 mRNA. Translation: AAI42013.1.
RefSeqiNP_001092400.1. NM_001098930.2.
UniGeneiBt.20356.

Genome annotation databases

EnsembliENSBTAT00000057188; ENSBTAP00000047624; ENSBTAG00000038337.
GeneIDi510480.
KEGGibta:510480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC142012 mRNA. Translation: AAI42013.1 .
RefSeqi NP_001092400.1. NM_001098930.2.
UniGenei Bt.20356.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000047624.

Proteomic databases

PRIDEi A5PJ93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000057188 ; ENSBTAP00000047624 ; ENSBTAG00000038337 .
GeneIDi 510480.
KEGGi bta:510480.

Organism-specific databases

CTDi 51237.

Phylogenomic databases

eggNOGi NOG74024.
GeneTreei ENSGT00390000002716.
HOGENOMi HOG000068171.
HOVERGENi HBG108230.
InParanoidi A5PJ93.
OMAi YQMWQHL.
OrthoDBi EOG7D2FFZ.
TreeFami TF329450.

Miscellaneous databases

NextBioi 20869462.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiMZB1_BOVIN
AccessioniPrimary (citable) accession number: A5PJ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3