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A5PJ93

- MZB1_BOVIN

UniProt

A5PJ93 - MZB1_BOVIN

Protein

Marginal zone B- and B1-cell-specific protein

Gene

MZB1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation By similarity.By similarity
    Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.By similarity

    GO - Biological processi

    1. integrin activation Source: UniProtKB
    2. negative regulation of glucose import in response to insulin stimulus Source: UniProtKB
    3. positive regulation of cell proliferation Source: UniProtKB
    4. positive regulation of immunoglobulin biosynthetic process Source: UniProtKB
    5. regulation of B cell proliferation Source: UniProtKB
    6. regulation of cell proliferation Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Marginal zone B- and B1-cell-specific protein
    Alternative name(s):
    Plasma cell-induced resident endoplasmic reticulum protein
    Short name:
    Plasma cell-induced resident ER protein
    Short name:
    pERp1
    Proapoptotic caspase adapter protein
    Gene namesi
    Name:MZB1
    Synonyms:PACAP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 7

    Subcellular locationi

    Endoplasmic reticulum lumen By similarity. Secreted By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum chaperone complex Source: UniProtKB
    2. endoplasmic reticulum lumen Source: UniProtKB
    3. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 189173Marginal zone B- and B1-cell-specific proteinPRO_0000318739Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 178By similarity
    Disulfide bondi53 ↔ 171By similarity
    Disulfide bondi95 ↔ 143By similarity

    Post-translational modificationi

    Forms an interchain disulfide bond with IgM monomers.By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiA5PJ93.

    Interactioni

    Subunit structurei

    Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000047624.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi186 – 1894Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the MZB1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74024.
    GeneTreeiENSGT00390000002716.
    HOGENOMiHOG000068171.
    HOVERGENiHBG108230.
    InParanoidiA5PJ93.
    OMAiYQMWQHL.
    OrthoDBiEOG7D2FFZ.
    TreeFamiTF329450.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5PJ93-1 [UniParc]FASTAAdd to Basket

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    MRLSLLLLLP LLGAWAIPGG FGDEASLTAT APELDDEEKF STHIPTHLRC    50
    DACRAVAYQM WQHLTKAEAK LLPLDSGGRR ELSESVYTDV LDQSCSQTWQ 100
    GYGVGEVDQV KRLMGPGLST GAQPSIMVMI MEGLWPTRLS KTCFHYLGEF 150
    GEDQIYEAHQ QGRGTLEALL CGGPRGACSE KAPDTRTEL 189
    Length:189
    Mass (Da):20,699
    Last modified:July 10, 2007 - v1
    Checksum:iA8A717AC1E76DE1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142012 mRNA. Translation: AAI42013.1.
    RefSeqiNP_001092400.1. NM_001098930.2.
    UniGeneiBt.20356.

    Genome annotation databases

    EnsembliENSBTAT00000057188; ENSBTAP00000047624; ENSBTAG00000038337.
    GeneIDi510480.
    KEGGibta:510480.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC142012 mRNA. Translation: AAI42013.1 .
    RefSeqi NP_001092400.1. NM_001098930.2.
    UniGenei Bt.20356.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000047624.

    Proteomic databases

    PRIDEi A5PJ93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000057188 ; ENSBTAP00000047624 ; ENSBTAG00000038337 .
    GeneIDi 510480.
    KEGGi bta:510480.

    Organism-specific databases

    CTDi 51237.

    Phylogenomic databases

    eggNOGi NOG74024.
    GeneTreei ENSGT00390000002716.
    HOGENOMi HOG000068171.
    HOVERGENi HBG108230.
    InParanoidi A5PJ93.
    OMAi YQMWQHL.
    OrthoDBi EOG7D2FFZ.
    TreeFami TF329450.

    Miscellaneous databases

    NextBioi 20869462.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thymus.

    Entry informationi

    Entry nameiMZB1_BOVIN
    AccessioniPrimary (citable) accession number: A5PJ93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3