A5PJ93 (MZB1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Marginal zone B- and B1-cell-specific protein

Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name=Plasma cell-induced resident ER protein
Short name=pERp1
Proapoptotic caspase adapter protein

Gene names

Name:	MZB1
Synonyms:	PACAP

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation By similarity. Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.
Subunit structure	Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains By similarity. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity. Secreted By similarity.
Post-translational modification	Forms an interchain disulfide bond with IgM monomers By similarity.
Sequence similarities	Belongs to the MZB1 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Secreted
Domain	Signal
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	integrin activation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of glucose import in response to insulin stimulus Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of immunoglobulin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB regulation of B cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum chaperone complex Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum lumen Inferred from sequence or structural similarity. Source: UniProtKB extracellular region Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 189	173	Marginal zone B- and B1-cell-specific protein		PRO_0000318739
Regions
	Motif	186 – 189	4	Prevents secretion from ER Potential
Amino acid modifications
	Disulfide bond	50 ↔ 178		By similarity
	Disulfide bond	53 ↔ 171		By similarity
	Disulfide bond	95 ↔ 143		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5PJ93 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: A8A717AC1E76DE1E	FASTA	189	20,699
	10 20 30 40 50 60 MRLSLLLLLP LLGAWAIPGG FGDEASLTAT APELDDEEKF STHIPTHLRC DACRAVAYQM 70 80 90 100 110 120 WQHLTKAEAK LLPLDSGGRR ELSESVYTDV LDQSCSQTWQ GYGVGEVDQV KRLMGPGLST 130 140 150 160 170 180 GAQPSIMVMI MEGLWPTRLS KTCFHYLGEF GEDQIYEAHQ QGRGTLEALL CGGPRGACSE KAPDTRTEL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC142012 mRNA. Translation: AAI42013.1.
IPI	IPI00717743.
RefSeq	NP_001092400.1. NM_001098930.2.
UniGene	Bt.20356.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000047624.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000057188; ENSBTAP00000047624; ENSBTAG00000038337.
GeneID	510480.
KEGG	bta:510480.
Organism-specific databases
CTD	51237.
Phylogenomic databases
eggNOG	NOG74024.
GeneTree	ENSGT00390000002716.
HOGENOM	HOG000068171.
HOVERGEN	HBG108230.
InParanoid	A5PJ93.
OMA	EKYSAHM.
OrthoDB	EOG4ZGPDG.
Family and domain databases
PROSITE	PS00014. ER_TARGET. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20869462.

Entry information

Entry name

MZB1_BOVIN

Accession

Primary (citable) accession number: A5PJ93

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 10, 2007
Last modified:	April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program