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A5PJ93 (MZB1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Marginal zone B- and B1-cell-specific protein
Alternative name(s):
Plasma cell-induced resident endoplasmic reticulum protein
Short name=Plasma cell-induced resident ER protein
Short name=pERp1
Proapoptotic caspase adapter protein
Gene names
Name:MZB1
Synonyms:PACAP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion, and integrin activation By similarity.

Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance By similarity.

Subunit structure

Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains By similarity. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity. Secreted By similarity.

Post-translational modification

Forms an interchain disulfide bond with IgM monomers By similarity.

Sequence similarities

Belongs to the MZB1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 189173Marginal zone B- and B1-cell-specific protein
PRO_0000318739

Regions

Motif186 – 1894Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond50 ↔ 178 By similarity
Disulfide bond53 ↔ 171 By similarity
Disulfide bond95 ↔ 143 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5PJ93 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: A8A717AC1E76DE1E

FASTA18920,699
        10         20         30         40         50         60 
MRLSLLLLLP LLGAWAIPGG FGDEASLTAT APELDDEEKF STHIPTHLRC DACRAVAYQM 

        70         80         90        100        110        120 
WQHLTKAEAK LLPLDSGGRR ELSESVYTDV LDQSCSQTWQ GYGVGEVDQV KRLMGPGLST 

       130        140        150        160        170        180 
GAQPSIMVMI MEGLWPTRLS KTCFHYLGEF GEDQIYEAHQ QGRGTLEALL CGGPRGACSE 


KAPDTRTEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thymus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC142012 mRNA. Translation: AAI42013.1.
RefSeqNP_001092400.1. NM_001098930.2.
UniGeneBt.20356.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000047624.

Proteomic databases

PRIDEA5PJ93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000057188; ENSBTAP00000047624; ENSBTAG00000038337.
GeneID510480.
KEGGbta:510480.

Organism-specific databases

CTD51237.

Phylogenomic databases

eggNOGNOG74024.
GeneTreeENSGT00390000002716.
HOGENOMHOG000068171.
HOVERGENHBG108230.
InParanoidA5PJ93.
OMAEKYSAHM.
OrthoDBEOG7D2FFZ.
TreeFamTF329450.

Family and domain databases

ProtoNetSearch...

Other

NextBio20869462.

Entry information

Entry nameMZB1_BOVIN
AccessionPrimary (citable) accession number: A5PJ93
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families