A5N8G9 (A5N8G9_CLOK5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
S-ribosylhomocysteine lyase-related protein EMBL EDK33600.1

Gene names

Ordered Locus Names:

CKL_1558

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Lyase SAAS SAAS003815 EMBL EDK33600.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5N8G9 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: E58FB50FA5096339	FASTA	165	18,695
	10 20 30 40 50 60 MEKITSFTIN HLELLPGVYV SRKDNINGAI ITTFDIRMTR PNFEPVMNTA ELHTIEHLGA 70 80 90 100 110 120 TFLRNHSEYG SKIVYFGPMG CRTGLYLLLG SDRGFESKEI IGLVKEMFQF IAEYEGEIPG 130 140 150 160 ALPKDCGNYL DMNLPMAKYL AKKYLEDVLD NISEKNLNYP KSSDS

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000673 Genomic DNA. Translation: EDK33600.1.
RefSeq	YP_001394948.1. NC_009706.1.
3D structure databases
ProteinModelPortal	A5N8G9.
ModBase	Search...
Protein-protein interaction databases
STRING	A5N8G9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5390810.
GenomeReviews	Gene locus CKL_1558 in contig CP000673_GR.
KEGG	ckl:CKL_1558.
NMPDR	fig|431943.4.peg.1601.
PATRIC	19464579. VBICloKlu111549_1624.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1854.
HOGENOM	HBG347473.
OMA	TTFDIRM.
ProtClustDB	PRK02260.
Family and domain databases
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5N8G9_CLOK5

Accession

Primary (citable) accession number: A5N8G9

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)