A5N8G4 (ARGC_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CKL_1553

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000076730
Sites
	Active site	148	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5N8G4 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 1B55CB08BC2C5F8E	FASTA	344	38,104
	10 20 30 40 50 60 MVQVGVIGGT GYVGAELIRL LSNHNKIKIS GISSTSYEGK SINSLYPGFY DLKELVCEKD 70 80 90 100 110 120 DEVIKRSDLI FLALPSGVSE PIVEKAVAKD KICIDMGADF RFKNESSYKK WYGKNFITPK 130 140 150 160 170 180 LHESSVYGLP ELNREYIKKS RVIGNPGCYA TSVQIGVLPL ISKGLIEEKG IIADCKSGLT 190 200 210 220 230 240 GAGKTLSESS HFVNCNESFS AYKVANHRHT PEIEENLNSV SKEGVKLTFI PHLIPINRGI 250 260 270 280 290 300 LSTIYTTPKD PIDIEKIHQK YCEFYKEEPF VRILPLGKVS KINNVRLSNY CCISIHYDSE 310 320 330 340 NNKLIIISCL DNMIKGAAGQ AIQNMNIVLG FDEKEGLTAL PAVF

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000673 Genomic DNA. Translation: EDK33595.1.
RefSeq	YP_001394943.1. NC_009706.1.
3D structure databases
ProteinModelPortal	A5N8G4.
ModBase	Search...
Protein-protein interaction databases
STRING	A5N8G4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5394392.
GenomeReviews	Gene locus CKL_1553 in contig CP000673_GR.
KEGG	ckl:CKL_1553.
NMPDR	fig|431943.4.peg.1596.
PATRIC	19464569. VBICloKlu111549_1619.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	CKLU431943:CKL_1553-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CLOK5

Accession

Primary (citable) accession number: A5N8G4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program