Reviewed, UniProtKB/Swiss-Prot A5N802 (ACKA_CLOK5)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CKL_1391

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 405	405	Acetate kinase HAMAP MF_00020		PRO_1000074184

Sequences

	Sequence		Length	Mass (Da)
	A5N802-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 468BDCF12E8C5C07	FASTA	405	44,449
	10 20 30 40 50 60 MKILEVNCGS SSLKYQLIDM EDEKVLAKGL VERIGIDGSI LTHKVNGEKH VVSEPIKDHR 70 80 90 100 110 120 VAVKLVLEAL VDKQHGVIKD MSEISAVGHR VVHGGEQYSD AVIIDDKVME SLKDCSKLAP 130 140 150 160 170 180 LHNPPNIIGI NACKAIMPNT PMVAVFDTAF HHTMPKYAYI YPLPYELYER YGIRKYGFHG 190 200 210 220 230 240 TSHRFVSEEA ARLMGKDISE LKIITCHLGN GASICAVDRG KSIDTNMGFT PLAGLAMGTR 250 260 270 280 290 300 CGDIDPAIIP FLTNEIGMSI DEISNIMNNK SGILGMSGIS SDFRDVEEIA SFKHDRRAQL 310 320 330 340 350 360 ALDVFYYRVK SFIGSYVAVL DGVDAIVFTA GVGENSSIGR AEICSGLTYL GITIDEEKNN 370 380 390 400 IRGKATEITT ANSKTKVFVI PTNEELVIAR DTKFLVQKKI SHKSK

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000673 Genomic DNA. Translation: EDK33433.1.
RefSeq	YP_001394781.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5392221.
GenomeReviews	Gene locus CKL_1391 in contig CP000673_GR.
KEGG	ckl:CKL_1391.
NMPDR	fig|431943.4.peg.1437.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5N802. SSDFRDV.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-13473.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_CLOK5

Accession

Primary (citable) accession number: A5N802

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)