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A5N802 (ACKA_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetate kinase
EC=2.7.2.1
Alternative name(s):
Acetokinase
Gene names
Name:ackA
Ordered Locus Names:CKL_1391
OrganismClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]
Taxonomic identifier431943 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020

ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020

Pathway

Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020

Subcellular location

Cytoplasm By similarity HAMAP MF_00020.

Sequence similarities

Belongs to the acetokinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processorganic acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Acetate kinase HAMAP MF_00020
PRO_1000074184

Sequences

Sequence LengthMass (Da)Tools
A5N802 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 468BDCF12E8C5C07

FASTA40544,449
        10         20         30         40         50         60 
MKILEVNCGS SSLKYQLIDM EDEKVLAKGL VERIGIDGSI LTHKVNGEKH VVSEPIKDHR 

        70         80         90        100        110        120 
VAVKLVLEAL VDKQHGVIKD MSEISAVGHR VVHGGEQYSD AVIIDDKVME SLKDCSKLAP 

       130        140        150        160        170        180 
LHNPPNIIGI NACKAIMPNT PMVAVFDTAF HHTMPKYAYI YPLPYELYER YGIRKYGFHG 

       190        200        210        220        230        240 
TSHRFVSEEA ARLMGKDISE LKIITCHLGN GASICAVDRG KSIDTNMGFT PLAGLAMGTR 

       250        260        270        280        290        300 
CGDIDPAIIP FLTNEIGMSI DEISNIMNNK SGILGMSGIS SDFRDVEEIA SFKHDRRAQL 

       310        320        330        340        350        360 
ALDVFYYRVK SFIGSYVAVL DGVDAIVFTA GVGENSSIGR AEICSGLTYL GITIDEEKNN 

       370        380        390        400 
IRGKATEITT ANSKTKVFVI PTNEELVIAR DTKFLVQKKI SHKSK

« Hide

References

[1]"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features."
Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000673 Genomic DNA. Translation: EDK33433.1.
RefSeqYP_001394781.1. NC_009706.1.

3D structure databases

ProteinModelPortalA5N802.
SMRA5N802. Positions 1-397.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5N802.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5392221.
GenomeReviewsGene locus CKL_1391 in contig CP000673_GR.
KEGGckl:CKL_1391.
NMPDRfig|431943.4.peg.1437.
PATRIC19464241. VBICloKlu111549_1455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0282.
HOGENOMHBG285863.
OMALIDMTNE.
ProtClustDBCLSK2474852.

Enzyme and pathway databases

BioCycCKLU431943:CKL_1391-MONOMER.
MetaCyc:MONOMER-13473.

Family and domain databases

HAMAPMF_00020. Acetate_kinase.
[Tree]
InterProIPR004372. Ac/Proprionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
[Graphical view]
KOK00925.
PANTHERPTHR21060. Acetate_kin. 1 hit.
PfamPF00871. Acetate_kinase. 1 hit.
[Graphical view]
PIRSFPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSPR00471. ACETATEKNASE.
TIGRFAMsTIGR00016. AckA. 1 hit.
PROSITEPS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACKA_CLOK5
AccessionPrimary (citable) accession number: A5N802
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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