A5N7N9 (TRPF_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	trpF
Ordered Locus Names:	CKL_1278

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium kluyveri

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135		PRO_1000076435

Sequences

	Sequence		Length	Mass (Da)
	A5N7N9 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: E1135957C37E9645	FASTA	199	22,798
	10 20 30 40 50 60 MIKVKICGLK RDEDIKCVNR YKPDYVGFVF SKSKRQVNLE QAKMLIANLD SSIKSVGVFV 70 80 90 100 110 120 DEALEYVYNT SKILALDVIQ FHGLEDEEYM RHFNEFTIWK ALKVRCREDI LNLNYKYADG 130 140 150 160 170 180 IVLDNKTAGS GKCFDWDIAR HIKIKKDLIL AGGINEENVE TAAYIVNPDI VDVSSGVESQ 190 GYKDSSKIKM FIEKVRNIK

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000673 Genomic DNA. Translation: EDK33320.1.
RefSeq	YP_001394668.1. NC_009706.1.
3D structure databases
ProteinModelPortal	A5N7N9.
ModBase	Search...
Protein-protein interaction databases
STRING	431943.CKL_1278.
Proteomic databases
PRIDE	A5N7N9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EDK33320; EDK33320; CKL_1278.
GeneID	5391168.
KEGG	ckl:CKL_1278.
PATRIC	19464007. VBICloKlu111549_1338.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0135.
HOGENOM	HOG000161598.
KO	K01817.
OMA	PVIRAIQ.
ProtClustDB	CLSK2474828.
Enzyme and pathway databases
BioCyc	CKLU431943:GJF1-1278-MONOMER.
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00135. PRAI.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_CLOK5

Accession

Primary (citable) accession number: A5N7N9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program