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Protein

Glutamine--tRNA ligase

Gene

glnS

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66L-glutamineUniRule annotation1
Binding sitei210L-glutamineUniRule annotation1
Binding sitei229ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 36ATPUniRule annotation3
Nucleotide bindingi40 – 46ATPUniRule annotation7
Nucleotide bindingi259 – 260ATPUniRule annotation2
Nucleotide bindingi267 – 269ATPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)
Alternative name(s):
Glutaminyl-tRNA synthetaseUniRule annotation
Short name:
GlnRSUniRule annotation
Gene namesi
Name:glnSUniRule annotation
Ordered Locus Names:CKL_1022
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000002411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000954831 – 556Glutamine--tRNA ligaseAdd BLAST556

Proteomic databases

PRIDEiA5N6Y3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi431943.CKL_1022

Structurei

3D structure databases

ProteinModelPortaliA5N6Y3
SMRiA5N6Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 43"HIGH" regionUniRule annotationAdd BLAST11
Motifi266 – 270"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CX6 Bacteria
COG0008 LUCA
HOGENOMiHOG000259232
KOiK01886
OMAiVTHSICT
OrthoDBiPOG091H00G9

Family and domain databases

Gene3Di1.10.1160.10, 1 hit
2.40.240.10, 3 hits
3.40.50.620, 2 hits
HAMAPiMF_00126 Gln_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004514 Gln-tRNA-synth
IPR022861 Gln_tRNA_ligase_bac
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020061 Glu_tRNA_lig_a-bdl
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00440 glnS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A5N6Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNNNSSNF IKNIIIEDLK SGEYEKVVTR FPPEPNGYLH IGHAKSIVLN
60 70 80 90 100
FSLADEFEGK VNLRFDDTNP SKEDVEYVES IKEDVKWLGY NWDNLCFASS
110 120 130 140 150
YFERMYEYAV FLIKKGKAYV CDLTADEIRE YRGTLTKPGK ESPYRNRDVE
160 170 180 190 200
ENFKLFEGMK NGEFKDGEKV LRAKIDMASP NINMRDPVLY RIAHASHHNT
210 220 230 240 250
GDRWCIYPMY DFAHPLEDAI EGVTHSICTL EFEDHRPLYD WIIQECEIEN
260 270 280 290 300
RPKQIEFARL NMTNTVMSKR KLKQLVDENF VDGWDDPRMP TIAGLRRRGF
310 320 330 340 350
TPESIRNFCR AIGVSKASSI VDSQMLDYFL RDDLEKEAPR TMAILNPLKV
360 370 380 390 400
VITNYPEGKT ETFKIENNPD DASAGVREVP FSREIYIEQE DFMENPPKKY
410 420 430 440 450
YRLFPGNEVR LKSAYFIKCT EAIKDKDGNV IELRCTYDPA SKGGNSPDGR
460 470 480 490 500
KVRGTLHWIN VDTAIPAEIR LYEPLILEQQ EKEGEEDLFL DHVNPNSLKV
510 520 530 540 550
VKGFVEPDMK HVKSDEKFQF FRHGYFVLDG KCSKNGELVF NRIVSLKSSF

KIPENK
Length:556
Mass (Da):64,440
Last modified:July 10, 2007 - v1
Checksum:iF54B497C7FBED2F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA Translation: EDK33064.1
RefSeqiWP_012101396.1, NC_009706.1

Genome annotation databases

EnsemblBacteriaiEDK33064; EDK33064; CKL_1022
KEGGickl:CKL_1022

Similar proteinsi

Entry informationi

Entry nameiSYQ_CLOK5
AccessioniPrimary (citable) accession number: A5N6Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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