Reviewed, UniProtKB/Swiss-Prot A5N6F5 (ADD_CLOK5)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	CKL_0833

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Adenosine deaminase HAMAP MF_00540		PRO_1000081922
Sites
	Active site	201	1	Potential
	Active site	249	1	Potential
	Active site	282	1	Potential
	Active site	283	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	A5N6F5-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: C99FF50FBD428745	FASTA	348	39,715
	10 20 30 40 50 60 MNLNKILKLI PKTDLHCHLD GSLRPETILD IAYKENIPLP NKELANFQEE IKVIGKCTSL 70 80 90 100 110 120 KEYLNKFNLP IQIMQKEEHI YRVTLELLED ALKQNIKYIE IRFAPFNHLK DGLTLDQVIN 130 140 150 160 170 180 TVLTAMNYGR THLNIMSNLI LCILRQEPVE KGIELVNTAK KYVGKGVVAV DLAGNESDFP 190 200 210 220 230 240 PEIHEEAFTL ARKYGLHRTV HAGETGLPEN IIKSINILGA ERIGHGTYAY KDKEIITCLK 250 260 270 280 290 300 ENRIPLEVCI TSNVNTSAVT SYQEHPIKKY LDEDLIITVN TDNTTVSNTN LIEEFNYLIK 310 320 330 340 YQSFRFDDIK KVIKNGIESS FASKEDINKL YEEYLSAINV IELTNPIL

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000673 Genomic DNA. Translation: EDK32886.1.
RefSeq	YP_001394234.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5N6F5.
Genome annotation databases
GeneID	5392254.
GenomeReviews	Gene locus CKL_0833 in contig CP000673_GR.
KEGG	ckl:CKL_0833.
NMPDR	fig|431943.4.peg.871.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GQNVYDA.
Family and domain databases
HAMAP	MF_00540. [Tree]
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_CLOK5

Accession

Primary (citable) accession number: A5N6F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)