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A5N6A8 (AROB_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:CKL_0786
OrganismClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]
Taxonomic identifier431943 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3593593-dehydroquinate synthase HAMAP MF_00110
PRO_1000094491

Sequences

Sequence LengthMass (Da)Tools
A5N6A8 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 5537004EAE166A49

FASTA35940,459
        10         20         30         40         50         60 
MKAIDINVKE KSYKISIKKG ILSSIGERLK TTYQSRNIVV ITDTNVEKFY METLKNSLLE 

        70         80         90        100        110        120 
SGFTMKIISI EPGEKSKNLA TLERVYEKLC EFQIRRKDII ISLGGGVVGD LSGFAASTYL 

       130        140        150        160        170        180 
RGINYIQVPT SLLAQVDSSI GGKVAVDLPW GKNLVGSFYH PDAVFIDPDV LLSLNDKFFS 

       190        200        210        220        230        240 
DGMGEVIKYG FIKDKSILNL LDSCKDKDEV LQYIEDIIYK CCSIKKHLVE KDERDLGERM 

       250        260        270        280        290        300 
MLNFGHTLAH GIEKYYNYGK YSHGEAVAIG MTYMTNITER MDITKKGTHD YMKGILTKYG 

       310        320        330        340        350 
LPVNMPDMDK QALVNSIALD KKSSGDRINI IVIEEAGICK IMKIKLREVY GFLFPEDII

« Hide

References

[1]"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features."
Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000673 Genomic DNA. Translation: EDK32839.1.
RefSeqYP_001394187.1. NC_009706.1.

3D structure databases

ProteinModelPortalA5N6A8.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5N6A8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5391472.
GenomeReviewsGene locus CKL_0786 in contig CP000673_GR.
KEGGckl:CKL_0786.
NMPDRfig|431943.4.peg.823.
PATRIC19463009. VBICloKlu111549_0850.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycCKLU431943:CKL_0786-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_CLOK5
AccessionPrimary (citable) accession number: A5N6A8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 10, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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