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A5N5L9 (A5N5L9_CLOK5) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:idh EMBL EDK32600.1
Ordered Locus Names:CKL_0546 EMBL EDK32600.1
OrganismClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP] EMBL EDK32600.1
Taxonomic identifier431943 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length401 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region95 – 1017Substrate binding By similarity

Sites

Metal binding2511Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2741Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site781Substrate By similarity
Binding site1101Substrate By similarity
Binding site1331Substrate By similarity
Site1401Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2111Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A5N5L9 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 7D457928FFA7FF20

FASTA40145,998
        10         20         30         40         50         60 
MTEKIKMNVP LVEMDGDEMT RIIWKMIKEL LLEPYIDLKT EYYDLGLVKR NETNDEITIE 

        70         80         90        100        110        120 
AANAIKKYGV GVKCATITPN AKRVKEYNLK SMWKSPNGTI RAILDGTVFR TPIIVNSIRP 

       130        140        150        160        170        180 
LMRTWEKPIT VARHAYGDVY RDVEYKVEEP GKMELVFTSE KGEETRQTLH VFNGPGVVMG 

       190        200        210        220        230        240 
MHNLDKSIES FARSCFNYAL DMNQNLWFAS KDTISKTYDH RFKDIFQEIY DTEYDAKFND 

       250        260        270        280        290        300 
AGIEYFYTLI DDAVARVVKS EGGFIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPEGY 

       310        320        330        340        350        360 
YEYEAAHGTV QKHYYQHLKG QLTSTNSMAT LFAWTGALRK RGEIDGINEL VEFADRLENT 

       370        380        390        400 
SIRTIEEGIM TKDLASLSEL ENKKIVNTEE FLLEIKKRLE E 

« Hide

References

[1]"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features."
Seedorf H., Fricke W.F., Veith B., Bruggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G.
Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000673 Genomic DNA. Translation: EDK32600.1.
RefSeqYP_001393948.1. NC_009706.1.

3D structure databases

ProteinModelPortalA5N5L9.
SMRA5N5L9. Positions 4-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING431943.CKL_0546.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEDK32600; EDK32600; CKL_0546.
GeneID5391728.
KEGGckl:CKL_0546.
PATRIC19462511. VBICloKlu111549_0602.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycCKLU431943:GJF1-546-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5N5L9_CLOK5
AccessionPrimary (citable) accession number: A5N5L9
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)