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A5N5L9

- A5N5L9_CLOK5

UniProt

A5N5L9 - A5N5L9_CLOK5

Protein

Isocitrate dehydrogenase [NADP]

Gene

idh

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781Substrate
    Binding sitei110 – 1101Substrate
    Binding sitei133 – 1331SubstrateUniRule annotation
    Sitei140 – 1401Critical for catalysisUniRule annotation
    Sitei211 – 2111Critical for catalysisUniRule annotation
    Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
    Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciCKLU431943:GJF1-546-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:idhImported
    Ordered Locus Names:CKL_0546Imported
    OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)Imported
    Taxonomic identifieri431943 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002411: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi431943.CKL_0546.

    Structurei

    3D structure databases

    ProteinModelPortaliA5N5L9.
    SMRiA5N5L9. Positions 4-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 1017Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiKNTIMKV.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5N5L9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEKIKMNVP LVEMDGDEMT RIIWKMIKEL LLEPYIDLKT EYYDLGLVKR    50
    NETNDEITIE AANAIKKYGV GVKCATITPN AKRVKEYNLK SMWKSPNGTI 100
    RAILDGTVFR TPIIVNSIRP LMRTWEKPIT VARHAYGDVY RDVEYKVEEP 150
    GKMELVFTSE KGEETRQTLH VFNGPGVVMG MHNLDKSIES FARSCFNYAL 200
    DMNQNLWFAS KDTISKTYDH RFKDIFQEIY DTEYDAKFND AGIEYFYTLI 250
    DDAVARVVKS EGGFIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPEGY 300
    YEYEAAHGTV QKHYYQHLKG QLTSTNSMAT LFAWTGALRK RGEIDGINEL 350
    VEFADRLENT SIRTIEEGIM TKDLASLSEL ENKKIVNTEE FLLEIKKRLE 400
    E 401
    Length:401
    Mass (Da):45,998
    Last modified:July 10, 2007 - v1
    Checksum:i7D457928FFA7FF20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK32600.1.
    RefSeqiYP_001393948.1. NC_009706.1.

    Genome annotation databases

    EnsemblBacteriaiEDK32600; EDK32600; CKL_0546.
    GeneIDi5391728.
    KEGGickl:CKL_0546.
    PATRICi19462511. VBICloKlu111549_0602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK32600.1 .
    RefSeqi YP_001393948.1. NC_009706.1.

    3D structure databases

    ProteinModelPortali A5N5L9.
    SMRi A5N5L9. Positions 4-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 431943.CKL_0546.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EDK32600 ; EDK32600 ; CKL_0546 .
    GeneIDi 5391728.
    KEGGi ckl:CKL_0546.
    PATRICi 19462511. VBICloKlu111549_0602.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi KNTIMKV.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci CKLU431943:GJF1-546-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8527 / DSM 555 / NCIMB 10680Imported.

    Entry informationi

    Entry nameiA5N5L9_CLOK5
    AccessioniPrimary (citable) accession number: A5N5L9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3