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A5N5L9

- A5N5L9_CLOK5

UniProt

A5N5L9 - A5N5L9_CLOK5

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Protein

Isocitrate dehydrogenase [NADP]

Gene

idh

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331SubstrateUniRule annotation
Sitei140 – 1401Critical for catalysisUniRule annotation
Sitei211 – 2111Critical for catalysisUniRule annotation
Metal bindingi251 – 2511Magnesium or manganeseUniRule annotation
Metal bindingi274 – 2741Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idhImported
Ordered Locus Names:CKL_0546Imported
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)Imported
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_0546.

Structurei

3D structure databases

ProteinModelPortaliA5N5L9.
SMRiA5N5L9. Positions 4-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5N5L9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKIKMNVP LVEMDGDEMT RIIWKMIKEL LLEPYIDLKT EYYDLGLVKR
60 70 80 90 100
NETNDEITIE AANAIKKYGV GVKCATITPN AKRVKEYNLK SMWKSPNGTI
110 120 130 140 150
RAILDGTVFR TPIIVNSIRP LMRTWEKPIT VARHAYGDVY RDVEYKVEEP
160 170 180 190 200
GKMELVFTSE KGEETRQTLH VFNGPGVVMG MHNLDKSIES FARSCFNYAL
210 220 230 240 250
DMNQNLWFAS KDTISKTYDH RFKDIFQEIY DTEYDAKFND AGIEYFYTLI
260 270 280 290 300
DDAVARVVKS EGGFIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPEGY
310 320 330 340 350
YEYEAAHGTV QKHYYQHLKG QLTSTNSMAT LFAWTGALRK RGEIDGINEL
360 370 380 390 400
VEFADRLENT SIRTIEEGIM TKDLASLSEL ENKKIVNTEE FLLEIKKRLE

E
Length:401
Mass (Da):45,998
Last modified:July 10, 2007 - v1
Checksum:i7D457928FFA7FF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA. Translation: EDK32600.1.
RefSeqiWP_011989115.1. NC_009706.1.
YP_001393948.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK32600; EDK32600; CKL_0546.
GeneIDi5391728.
KEGGickl:CKL_0546.
PATRICi19462511. VBICloKlu111549_0602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA. Translation: EDK32600.1 .
RefSeqi WP_011989115.1. NC_009706.1.
YP_001393948.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N5L9.
SMRi A5N5L9. Positions 4-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_0546.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK32600 ; EDK32600 ; CKL_0546 .
GeneIDi 5391728.
KEGGi ckl:CKL_0546.
PATRICi 19462511. VBICloKlu111549_0602.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci CKLU431943:GJF1-546-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680Imported.

Entry informationi

Entry nameiA5N5L9_CLOK5
AccessioniPrimary (citable) accession number: A5N5L9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3