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A5N5L9

- A5N5L9_CLOK5

UniProt

A5N5L9 - A5N5L9_CLOK5

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Protein

Isocitrate dehydrogenase [NADP]

Gene
idh, CKL_0546
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781Substrate By similarityUniRule annotation
Binding sitei110 – 1101Substrate By similarityUniRule annotation
Binding sitei133 – 1331Substrate By similarityUniRule annotation
Sitei140 – 1401Critical for catalysis By similarityUniRule annotation
Sitei211 – 2111Critical for catalysis By similarityUniRule annotation
Metal bindingi251 – 2511Magnesium or manganese By similarity
Metal bindingi274 – 2741Magnesium or manganese By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:idhImported
Ordered Locus Names:CKL_0546Imported
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)Imported
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_0546.

Structurei

3D structure databases

ProteinModelPortaliA5N5L9.
SMRiA5N5L9. Positions 4-401.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 1017Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5N5L9-1 [UniParc]FASTAAdd to Basket

« Hide

MTEKIKMNVP LVEMDGDEMT RIIWKMIKEL LLEPYIDLKT EYYDLGLVKR    50
NETNDEITIE AANAIKKYGV GVKCATITPN AKRVKEYNLK SMWKSPNGTI 100
RAILDGTVFR TPIIVNSIRP LMRTWEKPIT VARHAYGDVY RDVEYKVEEP 150
GKMELVFTSE KGEETRQTLH VFNGPGVVMG MHNLDKSIES FARSCFNYAL 200
DMNQNLWFAS KDTISKTYDH RFKDIFQEIY DTEYDAKFND AGIEYFYTLI 250
DDAVARVVKS EGGFIWACKN YDGDVMSDMV ATAFGSLAMM TSVLVSPEGY 300
YEYEAAHGTV QKHYYQHLKG QLTSTNSMAT LFAWTGALRK RGEIDGINEL 350
VEFADRLENT SIRTIEEGIM TKDLASLSEL ENKKIVNTEE FLLEIKKRLE 400
E 401
Length:401
Mass (Da):45,998
Last modified:July 10, 2007 - v1
Checksum:i7D457928FFA7FF20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK32600.1.
RefSeqiYP_001393948.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK32600; EDK32600; CKL_0546.
GeneIDi5391728.
KEGGickl:CKL_0546.
PATRICi19462511. VBICloKlu111549_0602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK32600.1 .
RefSeqi YP_001393948.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N5L9.
SMRi A5N5L9. Positions 4-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_0546.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK32600 ; EDK32600 ; CKL_0546 .
GeneIDi 5391728.
KEGGi ckl:CKL_0546.
PATRICi 19462511. VBICloKlu111549_0602.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci CKLU431943:GJF1-546-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiA5N5L9_CLOK5
AccessioniPrimary (citable) accession number: A5N5L9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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