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A5N5B3

- FTHS_CLOK5

UniProt

A5N5B3 - FTHS_CLOK5

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 738ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-440-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:CKL_0440
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000087651Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_0440.

Structurei

3D structure databases

ProteinModelPortaliA5N5B3.
SMRiA5N5B3. Positions 6-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5N5B3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFKSDIQIA QECSMENIKD IAKKLNIFED EIELYGKYKA KIDYNLLKTT
60 70 80 90 100
KGKNGKLILC TAINPTPAGE GKTTTSIGVA DALARLDKSV VVALREPSMG
110 120 130 140 150
PVFGIKGGAA GGGYAQVVPM EDINLHFTGD IHAMTAANNL LAALIDNHIY
160 170 180 190 200
QGNKLNIDSR RVVWRRCVDM NDRQLRFVVD GLGGKVNGIP REDGFDITVA
210 220 230 240 250
SEIMAIFCLS TDINDLKERI SKIVVGYTTE GNPVTAHDLK AEGAMAALLK
260 270 280 290 300
DALKPNLVQT LEGTPAFVHG GPFANIAHGC NSIMATRMAM HFGDYVVTEA
310 320 330 340 350
GFGADLGAEK FLDIKCRMAG LRPDAVIIVA TVRALKYNGG TPKTKLNNEN
360 370 380 390 400
LETLEKGIPN LLKHVENITK VFKLPAVVAL NAFPTDTEAE LKLVEEKCRE
410 420 430 440 450
FGVSVKLSEV WAKGGEGGIE VAKEVLRLIN EGKNDFQFAY DEKLPIRDKI
460 470 480 490 500
RAIAQKIYGA DGVTFTNQAE KEIDELEKLG FGKTPVCIAK TQYSLTDDQN
510 520 530 540 550
KLGRPKGFKI TVRQVSISAG AGFVVAITGS IMKMPGLPKV PAAEKIDVDE

NGVISGLF
Length:558
Mass (Da):60,414
Last modified:July 10, 2007 - v1
Checksum:i6E7ABE3A88C40AE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA. Translation: EDK32494.1.
RefSeqiYP_001393842.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK32494; EDK32494; CKL_0440.
GeneIDi5391110.
KEGGickl:CKL_0440.
PATRICi19462281. VBICloKlu111549_0487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA. Translation: EDK32494.1 .
RefSeqi YP_001393842.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N5B3.
SMRi A5N5B3. Positions 6-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_0440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK32494 ; EDK32494 ; CKL_0440 .
GeneIDi 5391110.
KEGGi ckl:CKL_0440.
PATRICi 19462281. VBICloKlu111549_0487.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CKLU431943:GJF1-440-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiFTHS_CLOK5
AccessioniPrimary (citable) accession number: A5N5B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3