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A5N5B3

- FTHS_CLOK5

UniProt

A5N5B3 - FTHS_CLOK5

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi66 – 738ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCKLU431943:GJF1-440-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CKL_0440
    OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
    Taxonomic identifieri431943 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002411: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000087651Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi431943.CKL_0440.

    Structurei

    3D structure databases

    ProteinModelPortaliA5N5B3.
    SMRiA5N5B3. Positions 6-556.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5N5B3-1 [UniParc]FASTAAdd to Basket

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    MNFKSDIQIA QECSMENIKD IAKKLNIFED EIELYGKYKA KIDYNLLKTT    50
    KGKNGKLILC TAINPTPAGE GKTTTSIGVA DALARLDKSV VVALREPSMG 100
    PVFGIKGGAA GGGYAQVVPM EDINLHFTGD IHAMTAANNL LAALIDNHIY 150
    QGNKLNIDSR RVVWRRCVDM NDRQLRFVVD GLGGKVNGIP REDGFDITVA 200
    SEIMAIFCLS TDINDLKERI SKIVVGYTTE GNPVTAHDLK AEGAMAALLK 250
    DALKPNLVQT LEGTPAFVHG GPFANIAHGC NSIMATRMAM HFGDYVVTEA 300
    GFGADLGAEK FLDIKCRMAG LRPDAVIIVA TVRALKYNGG TPKTKLNNEN 350
    LETLEKGIPN LLKHVENITK VFKLPAVVAL NAFPTDTEAE LKLVEEKCRE 400
    FGVSVKLSEV WAKGGEGGIE VAKEVLRLIN EGKNDFQFAY DEKLPIRDKI 450
    RAIAQKIYGA DGVTFTNQAE KEIDELEKLG FGKTPVCIAK TQYSLTDDQN 500
    KLGRPKGFKI TVRQVSISAG AGFVVAITGS IMKMPGLPKV PAAEKIDVDE 550
    NGVISGLF 558
    Length:558
    Mass (Da):60,414
    Last modified:July 10, 2007 - v1
    Checksum:i6E7ABE3A88C40AE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK32494.1.
    RefSeqiYP_001393842.1. NC_009706.1.

    Genome annotation databases

    EnsemblBacteriaiEDK32494; EDK32494; CKL_0440.
    GeneIDi5391110.
    KEGGickl:CKL_0440.
    PATRICi19462281. VBICloKlu111549_0487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK32494.1 .
    RefSeqi YP_001393842.1. NC_009706.1.

    3D structure databases

    ProteinModelPortali A5N5B3.
    SMRi A5N5B3. Positions 6-556.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 431943.CKL_0440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EDK32494 ; EDK32494 ; CKL_0440 .
    GeneIDi 5391110.
    KEGGi ckl:CKL_0440.
    PATRICi 19462281. VBICloKlu111549_0487.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CKLU431943:GJF1-440-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

    Entry informationi

    Entry nameiFTHS_CLOK5
    AccessioniPrimary (citable) accession number: A5N5B3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3